The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta‐analysis

Wu, Tao; Qiu, Shi; Wang, Peifu; Li, Jilai; Li, Qin; Du, Jichen

doi:10.1002/brb3.482

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…There were no significant associations of the +936 C > T genotypes with the susceptibility. This result is inconsistent with what has been shown in some previous studies [ 28 ], which may be due to the selection bias of IS patients or some potential confounding factors that influenced the distribution of the genotype. Therefore, we further assessed the severity and the 3 month outcomes of IS in relation to the polymorphisms and found that the subjects with the TT genotype of rs3029039 exhibited an increased risk of poor outcome at 90 days after IS onset.…”

Section: Discussioncontrasting

confidence: 99%

“…Several variants in the VEGFA promoter and exons have been reported to predispose carriers to the development of IS [ 17 ]. A recent meta-analysis also demonstrated that +936C>T may be a risk factor for stroke among Asians [ 28 ], even though inconsistent result was observed in a Chinese population [ 29 ]. In the present study, we also evaluated the distribution of the VEGFA +936 C > T polymorphism in 494 IS patients and 337 healthy control.…”

Section: Discussionmentioning

confidence: 99%

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A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

et al. 2017

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Vascular endothelial growth factor (VEGF) plays critical roles in angiogenesis and vasculogenesis, which are associated with post-stroke functional recovery. However, the effects of the VEGFA polymorphisms on the outcome of ischemic stroke (IS) have been rarely reported. We therefore investigated the associations of +936C/T variant (rs3025039) with the susceptibilities and the 90-day outcomes from 494 IS patients and 337 healthy controls in Chinese population through the establishment of logistic multivariate regression model. Stroke severity at admission and outcome of 90 days were respectively assessed according to the National Institutes of Health Stroke Scale and the modified Rankin Scale. The analysis showed that there were no significant associations of the rs3025039 genotypes with the susceptibility (P = 0.229) and the severity (P = 0.734). However, when we divided the 308 IS patients into two groups according to the different outcomes, we found that the rs3025039 TC+TT genotype significantly increased the risk of poor recovery [adjusted odds ratio (OR), 1.99; 95% confidence interval (CI), 1.18–3.37]. Interestingly, we observed another 3ˈUTR variant, +1451C/T (rs3025040), exhibited strong linkage disequilibrium (r2 = 1.0) with +936C/T and was located in a predicted microRNA-binding site. The rs3025040 T allele significantly decreased the luciferase activities in four cell lines, which indicated a potential disruption of the miRNA-mRNA interaction that would result in lower VEGF expression levels. Our data suggested that the +936C/T variants significantly increased the risk of poorer stroke outcome by affecting the bindings of miR-199a and miR-199b to VEGF mRNA at the rs30250340 polymorphic site.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

et al. 2017

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“…Although emerging meta-analysis showed that +936 C/T may be involved in the risk of stroke, there were some conflicting results. [ 11 ] For example, the literature was not comprehensive enough, and not all the articles were consistent with the Hardy–Weinberg equilibrium (HWE). To further examine the role of VEGF in stroke, we performed a meta-analysis to evaluate the association between VEGF gene polymorphisms and stroke risk.…”

Section: Introductionmentioning

confidence: 99%

The association between vascular endothelial growth factor gene polymorphisms and stroke

Xu¹,

Zhan

Mai³

et al. 2019

Medicine

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Background:Numerous studies showed that vascular endothelial growth factor (VEGF) gene polymorphisms were linked with the regularity of stroke, but the results remained controversial. The aim of this meta-analysis was to determine the associations between VEGF gene polymorphisms and the risk of stroke.Methods:A systematic literature search of PubMed, Embase, Wed of Science, The Cochrane Library, Elsevier, China National Knowledge Infrastructure, China Biology Medicine disc, WanFang Data, VIP Database for Chinese Technical Periodicals, and Science paper Online was conducted. Two authors independently assessed trial quality and extracted data. The pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of associations. Begger funnel plot and Egger test were used to estimate the publication bias of included studies. Heterogeneity assumption was assessed by Cochran Chi-squared-based Q-statistic test and I2 test.Results:Thirteen publications including 23 trails with a total of 3794 stroke patients and 3094 control subjects were enrolled. About 3747 cases and 2868 controls for +936C/T, 2134 cases and 1424 controls for −2578C/A, and 2187 cases and 1650 controls for −1154G/A were examined, respectively. The results indicated that VEGF +936C/T (T vs C, OR = 1.19, 95% CI = 1.01–1.40) or −2578C/A (A vs C, OR = 1.13, 95% CI = 1.02–1.27) was positively associated with the risk of stroke, whereas there was no association between −1154G/A (A vs G, OR = 0.99, 95% CI = 0.87–1.11) polymorphism and stroke risk in our study. Among the subgroup analyses on ethnicity, the results showed that VEGF +936C/T was an increased risk of stroke in Asian population (T vs C, OR = 1.21, 95% CI = 1.01–1.44), but not −1154G/A.Conclusion:Our findings suggest that VEGF +936C/T and −2578C/A might be related to the risk of stroke, especially in the Asian population, but not −1154G/A.

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“…The human vascular endothelial growth factor (VEGF) gene is located on chromosome 6 at location 6p21.3 and consists of 8 exons [ 14 ]. VEGF gene is highly polymorphic, and its promoter, 5’-, and 3’-UTR has a variety of SNPs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Studies showed that polymorphic events affecting the mRNA expression of VEGF gene could affect the survival duration of cancer patients having received anti-angiogenic treatment [ 18 ]. Therefore, VEGF gene polymorphisms might also serve as potential molecular biomarkers to predict clinical outcomes [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

KRAS and VEGF gene 3'-UTR single nucleotide polymorphisms predicted susceptibility in colorectal cancer

et al. 2017

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Single nucleotide polymorphisms (SNPs) in tumor-related genes have been reported to play important roles in cancer development. Recent studies have shown that 3’-untranslated regions (UTR) polymorphisms are associated with the occurrence and prognosis of cancers. The aim of this study is to analyze the association between KRAS and VEGF gene 3’-UTR SNPs and genetic susceptibility to colorectal cancer (CRC). In this case-control study of 371 CRC cases and 246 healthy controls, we analyzed the association between one SNP (rs1137188G > A) in the KRAS gene and four SNPs (rs3025039C > T, rs3025040C > T, rs3025053G > A and rs10434A > G) in the VEGF gene and CRC susceptibility by the improved multiplex ligase detection reaction (iMLDR) method. We checked the selected SNPs’ minor allele frequency and its distribution in the frequency of Chinese people by Hap-map database and Hardy-Weinberg equilibrium, and used multivariate logistic regression models to estimate adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs). We found that the rs3025039C variant genotype in the VEGF gene was associated with a significant protection for CRC (AOR = 0.693, 95% CI = 0.485–0.989; P = 0.043 for CC and CT+TT). Nevertheless, the difference was no longer significant after Bonferroni correction (Bonferroni-adjusted P = 0.172). In genetic polymorphisms analysis, we found that the KRAS rs1137188 variant AA genotype had higher portion of tumor size (≥ 5 cm) (P = 0.01; Bonferroni-adjusted P = 0.04), which suggested that the rs1137188 variant AA genotype may significantly be associated with increased progression of CRC. In conclusion, our study suggested that these five SNPs in the KRAS gene and the VEGF gene were not associated with CRC susceptibility in Han Chinese in Sichuan province.

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The association between vascular endothelial growth factor gene polymorphisms and stroke: a meta‐analysis

Cited by 8 publications

References 23 publications

A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

A functional variant in the 3ˈ-UTR of VEGF predicts the 90-day outcome of ischemic stroke in Chinese patients

The association between vascular endothelial growth factor gene polymorphisms and stroke

KRAS and VEGF gene 3'-UTR single nucleotide polymorphisms predicted susceptibility in colorectal cancer

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