The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease

Çiftdoğan, Dilek Yılmaz; Coşkun, Şenol; Ulman, Cevval; Tıkız, Hakan

doi:10.1016/j.jacl.2011.06.017

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…The relationship with CAD and APOE mutation was not significant because there was no numerical match between patient-control groups due to data loss. In contrast to our study, E4 allele was found to be higher in another study from Turkey including 70 children with coronary artery disease and 67 controls and also in children with E4 allele, T-Arm and LDL levels were found to be high [59]. In a meta-analysis including 6634 CAD patients and 6394 controls from China, it was reported that the APOE E4 allele may be a risk factor for CAD [60].…”

Section: Apoe Mutationscontrasting

confidence: 99%

Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease

Durmuş¹,

Nevin²,

Yuksel³

et al. 2020

Int J Blood Res Disord

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Background: Coronary artery disease (CAD) is a multifactorial disorder. It is important to identify gene mutations that may be responsible for the development of CAD. The aim of this study was to determine the frequency of twelve cardiovascular disease (CVD) related gene mutations in coronary artery patients. Methods:The CVD StripAssay (Vienna Lab, Austria) was performed to analyze the twelve gene mutations on 52 coronary artery patients and 39 healthy controls. After DNA isolation from blood samples, hybridization with biotin marked probes was performed to PCR products containing the related region of mutant genes. Chisquare tests were used for statistical analyses.Results: Any differences were not observed between coronary artery patients and healthy controls in terms of the frequencies of studied twelve gene mutations except MTHFR A1298C mutation. It was observed that heterozygous and homozygous mutant genotypes of MTHFR A1298C mutation have protective effects against coronary artery disease [p = 0.06, in 95% CI OR = 0.205 (0.0421-1.001)]. Although all the three genotypes of PAI-1 4G/5G, ACE I/D and MTHFR C677T mutations were observed in both groups; homozygous mutant genotypes weren't observed for the Factor V Leiden, Factor V H1299R, Prothrombin G20210A, Factor XIII V34L, β-Fibrinojen -455G > A, HPA-1 1a/1b mutations in any of the groups. Heterozygote and homozygote mutant genotypes of APOB R3500Q mutation was not seen in both groups. When the patient group was evaluated in terms of compound genotypes, the rate of two mutations (ACE I/D, MTHFR A1298C) was 56%, the rate of three mutations (PAI-1 4G/5G, MTHFR A1298C, ACE I/D) was 53%, the rate of four mutations (PAI-1 4G/5G, MTHFR A1298C, HPA-1 1a/1b, ACE I/D) was 33%. High cholesterol, the number of clogged arteries and smoking rates was high in CAD patients with compound genotypes or carrying mutations in multiple genes compared the others. Conclusion:Among 12 studied gene mutations, only the MTH-FR A1298C mutation was determined to have a protective effect against CAD. In addition, cumulative effects of the mutant genotypes and environmental factors on people with the combined genotypes may be trigger for CAD.

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Section: Apoe Mutationscontrasting

confidence: 99%

Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease

Durmuş¹,

Nevin²,

Yuksel³

et al. 2020

Int J Blood Res Disord

View full text Add to dashboard Cite

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“…Çiftdoğan et al evaluated the association of ApoE gene polymorphism and lipid levels in children with family history of premature CAD. The E4 allele may be associated with increased risk for development of atherosclerosis by elevated levels of TC [ 26 ]. Mendes-Lana et al demonstrated that the presence of ApoE2 may be a protective effect for CAD, and the presence of ApoE4 may show an enhanced risk of dyslipidemia [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Karahan

Uğurlu

Uçaman

et al. 2015

Cardiology Research and Practice

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Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score. In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score. But, the patients with E4 allele carriers were associated with high lipid levels.

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“…Apolipoprotein E (ApoE) is a multifunctional protein that plays an important role in lipoprotein metabolism [ 6 ]. Altered expression or genetic polymorphisms was considered as a risk factor for metabolic syndrome [ 7 ] and more recent studies have shown that ApoE also participates in immunoregulation by suppression of T lymphocyte proliferation and regulation of macrophage function [ 8 ]. ApoE may also be involved in the development of sporadic Alzheimer disease [ 9 - 11 ] or other diseases [ 12 - 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association of apolipoprotein E (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China

et al. 2015

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BackgroundApolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.MethodsA total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR.ResultsApolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p < 0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p < 0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p < 0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele.ConclusionsThis study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level.

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The association of apolipoprotein E polymorphism and lipid levels in children with a family history of premature coronary artery disease

Cited by 11 publications

References 32 publications

Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease

Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease

Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Association of apolipoprotein E (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China

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