The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis

Hochberg, Marc C.; Perlmutter, Donna

doi:10.1007/978-3-642-85226-8_44

Cited by 28 publications

(19 citation statements)

References 22 publications

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“…9 10 11 6 7 8 Moreover, the study provides results from a population outside North America, where most studies have been performed, adding further consistency to the findings 17. In our study the standardised hospitalisation ratio for definite connective tissue disease was 1.1 (upper 95% confidence limit 1.6).…”

Section: Discussionsupporting

confidence: 80%

“…In contrast to these case reports, most epidemiological studies have been unable to confirm an excess risk 6 7 8 9 10 11. Only one study reported a small but significant excess of self reported connective tissue disease 12.…”

Section: Introductionmentioning

confidence: 83%

“…Only one study reported a small but significant excess of self reported connective tissue disease 12. These epidemiological studies, however, have generally had limited statistical power to detect modest increases in risk of any specific connective tissue disease, although meta-analyses have also failed to demonstrate any excess risk 6 7 8…”

Section: Introductionmentioning

confidence: 99%

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Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden

Nyrén

Yin

Josefsson

et al. 1998

BMJ

120

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 83%

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Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden

Nyrén

Yin

Josefsson

et al. 1998

BMJ

120

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show abstract

“…Data from studies published through 2004 have been summarized in numerous meta-analyses, weight-of-the-evidence, and critical reviews, which have unanimously concluded that there is no evidence of an association between breast implants and any of the traditional CTDs evaluated individually or combined, or atypical CTD. 1,[41][42][43][44][45][46][47][48][49][50][51] The only finding of a relationship between CTDs and breast implants comes from a single large retrospective cohort study of female health professionals in the Women's Health Study. 52 This study found a small increased risk of self-reported (not validated) CTDs overall among women with breast implants.…”

Section: Breast Cancer Detectionmentioning

confidence: 99%

The Safety of Silicone Gel-Filled Breast Implants

McLaughlin

Lipworth²,

Murphy³

et al. 2007

Annals of Plastic Surgery

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Few implantable medical devices have been studied for their safety more extensively than silicone gel-filled breast implants. We summarize the epidemiologic evidence on the safety of breast implants, most of which is drawn from large cohort studies with long-term follow-up. The topics addressed in this report include cancer, breast cancer detection, connective tissue disease, suicide, offspring effects, neurologic disease, implant rupture, and local perioperative complications and additional surgery. We conclude that the weight of the epidemiologic evidence does not support a causal association between breast implants and breast or any other type of cancer, definite or atypical connective tissue disease, adverse offspring effects, or neurologic disease. Women with breast implants do not present with more advanced stages of breast cancer or suffer impaired survival after breast cancer diagnosis. The only study to examine an actual incidence rate of breast implant rupture reported rupture-free survival of 98% at 5 years and 83%-85% at 10 years for newer "third-generation" implants. Future studies are needed to determine whether the consistently observed excess of suicide among women with implants reflects underlying psychiatric illness prior to breast augmentation surgery or other factors.

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“…[14,15] However, these meta-analyses also had some statistical faults. None of these meta-analyses focused exclusively on silicone-gel filled breast implants.…”

Section: Autoimmunity and Silicone Breast Implantsmentioning

confidence: 98%

Silicone Gel Breast Implants and Connective Tissue Disease—A Comprehensive Review

Bar-Meir

Eherenfeld

Shoenfeld³

2003

Autoimmunity

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Silicone breast implants have been in use for breast reconstruction and breast augmentation for a long time. In the late 80's anecdotal reports describing a possible association between silicone-gel filled breast implants, and autoimmune diseases was accumulating. Due to the growing concern about the safety of silicone-gel implants, the Food and Drug administration (FDA) restricted their use to participants in controlled clinical trials, including women having reconstructive surgery. However, in recent years, large meta-analyses were unable to establish an association between silicone-gel breast implants and autoimmune disease. We review the current literature, emphasizing the most important epidemiologic studies.

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The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis

Cited by 28 publications

References 22 publications

Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden

Risk of connective tissue disease and related disorders among women with breast implants: a nation-wide retrospective cohort study in Sweden

The Safety of Silicone Gel-Filled Breast Implants

Silicone Gel Breast Implants and Connective Tissue Disease—A Comprehensive Review

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