The association of IL-1β, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women

Czerny, Bogusław; Kamiński, Adam; Kurzawski, Mateusz; Kotrych, Daniel; Safranow, Krzysztof; Dziedziejko, Violetta; Bohatyrewicz, Andrzej; Pawlik, Andrzej

doi:10.1016/j.ejogrb.2009.12.010

Cited by 37 publications

(25 citation statements)

References 26 publications

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“…Magana et al found that GÀ174C SNP and A3 allele of CA polymorphism of IL-6 gene were associated with increased BMD whereas GÀ572C SNP was not associated in 70 osteoporotic and 70 non-osteoporotic Mexican women [26]. Another investigator reported that among 226 postmenopausal Polish women with T-scores below À2.5 SD, the lumbar spine and femoral neck BMD values were significantly lower in the carriers of the IL-6 GG (À174 G>C) genotype compared with the CC and GC genotypes [27]. The frequency of IL-6 À174 G>C SNP in 198 Korean adolescent idiopathic scoliosis patients and 120 healthy girls was very low and because of this the genetic effect of this polymorphism could not be studied [28].…”

Section: Commentsmentioning

confidence: 94%

Is there any relation between IL-6 gene −174 G>C polymorphism and postmenopausal osteoporosis?

Deveci

Ozkan

Yüce

2012

European Journal of Obstetrics & Gynecology and Reproductiv

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Section: Commentsmentioning

confidence: 94%

Is there any relation between IL-6 gene −174 G>C polymorphism and postmenopausal osteoporosis?

Deveci

Ozkan

Yüce

2012

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Furthermore, there was a statistically significant association between the IL-6 -174 G/C polymorphism and osteoporosis in postmenopausal women (37). As the immune system plays such a critical role in the pathophysiology of postmenopausal osteoporosis, cytokines have the ability to influence each other; just as a mild increase in the production of proinflammatory cytokines would be found in a patient with osteoporosis, an increase in proinflammatory cytokines may exacerbate osteoporosis (37). Terauchi has suggested that counteracting these interactions could be a novel strategy for osteoporosis treatment (38).…”

Section: Discussionmentioning

confidence: 99%

“…The result suggested that among the women with T-scores <-2.5 SD, the BMD values were significantly lower in the carriers of the IL-6 GG genotype compared with those with the CC and GC genotypes. Furthermore, there was a statistically significant association between the IL-6 -174 G/C polymorphism and osteoporosis in postmenopausal women (37). As the immune system plays such a critical role in the pathophysiology of postmenopausal osteoporosis, cytokines have the ability to influence each other; just as a mild increase in the production of proinflammatory cytokines would be found in a patient with osteoporosis, an increase in proinflammatory cytokines may exacerbate osteoporosis (37).…”

Section: Discussionmentioning

confidence: 99%

“…ERα is predominant in a number of tissues and is primarily involved in the reproductive system, whereas ERβ is expressed in numerous tissues including bone (34). ERα and ERβ may be present in rat and human osteoblasts in cortical and trabecular compartments of bone (36,37), and a number of phytoestrogens, including genistein and coumestrol, show a higher affinity to ERβ (20).…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have investigated the associations between IL-1β gene polymorphisms and susceptibility to osteoporosis and BMD in various populations (35,36). A prior study enrolled 226 postmenopausal women with a diagnosed BMD T-score <-2.5 standard deviation (SD) and 224 postmenopausal women with a BMD T-score >-2.5 SD to investigate the associations between cytokine gene polymorphisms (IL-1β, IL-2 and IL-6) and BMD values (37). The result suggested that among the women with T-scores <-2.5 SD, the BMD values were significantly lower in the carriers of the IL-6 GG genotype compared with those with the CC and GC genotypes.…”

Section: Discussionmentioning

confidence: 99%

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Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects

Zheng

Huang

Zheng

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study was designed to evaluate the effect of olive oil on bone and uterus in ovariectomized rats. A total of 34 surgically ovariectomized or sham-operated virgin Sprague-Dawley rats were divided into four groups: i) Sham-operated control rats (sham group); ii) Ovariectomized rats (OVX group); iii) Olive oil-supplemented ovariectomized rats (olive group); and iv) Diethylstilbestrol-supplemented ovariectomized rats (E 2 group). At 12 weeks following left ventricular blood sacrificed to detect plasma estradiol (E 2 ), interleukin-1β (IL-1β) and IL-6 levels. Bone mineral density (BMD) of the lumbar spine was evaluated using dual-energy X-ray absorptiometry, and the left femur proximal 1/3 slices were observed using transmission electron microscopy. Uterine wet weight and the uterus index (ratio of uterine wet weight and body weight) were compared, and the uterine endometrium was observed using a light microscope. In the OVX group, serum E 2 was significantly lower and IL-1β and IL-6 levels were significantly higher compared with the sham group. By contrast, serum E 2 levels increased and IL-1β levels decreased in the olive group, but showed no significant difference compared with the sham group. The lumbar spine BMD in the olive group was increased compared with OVX group. Electron microscopy revealed sparse collagen fibers in the OVX group, with decreased density and multi-cavity, showing pathological features of osteoporosis. By contrast, the situation was improved in the E 2 and olive groups, in which organelles such as the rough endoplasmic reticulum, mitochondria and Golgi apparatus were visible and active. Compared with the sham group rats, the uterine wet weight and uterine index decreased in the OVX and olive groups; however, no statistically significant difference was observed in the E 2 group. Furthermore, endometrial hyperplasia was not observed in the olive group, which were apparently different from E 2 group. The present results suggest that olive oil can effectively reduce bone loss in ovariectomized rats, and with no or only mild effects on the uterine endothelium.

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IL‐1β inhibits osteogenesis of human bone marrow‐derived mesenchymal stem cells by activating FoxD3/microRNA‐496 to repress wnt signaling

Huang

Chen

2017

Genesis

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IL-1β, a major cytokine of proinflammatory response, has been implicated in bone loss. However, its effects on mesenchymal progenitor cells-associated bone regeneration remain elusive. Here, we investigated the role of microRNA for the regulation of osteogenesis by IL-1β in human bone marrow-derived mesenchymal stem cells (hBMMSC). Our data suggested Homo sapiens (hsa)-miR-496 is induced by IL-1β in hBMMSC and mediates the decreased β-catenin expression. Reporter assays using the 3'-UTR of β-catenin demonstrated sequence-dependent gene suppression with hsa-miR-496. IL-1β activated hsa-miR-496 expression through a transcription factor, Foxhead box D3 protein (FoxD3). The activation of hsa-miR-496 promoter in hBMMSC depended on a consensus FoxD3 binding motif. Under osteogenic differentiation, IL-1β treatment or overexpressing hsa-miR-496 attenuated bone mineralization and bone marker gene expressions in hBMMSC. Further, anti-miR-496 rescued the inhibitory effects of IL-1β. Our findings suggest a pivotal role of hsa-miR-496 in linking inflammation to impaired bone regeneration, and provide a rationale for using appropriate hsa-miR-496 inhibitors in the treatment of inflammation-associated bone loss.

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The association of IL-1β, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women

Cited by 37 publications

References 26 publications

Is there any relation between IL-6 gene −174 G>C polymorphism and postmenopausal osteoporosis?

Is there any relation between IL-6 gene −174 G>C polymorphism and postmenopausal osteoporosis?

Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects

IL‐1β inhibits osteogenesis of human bone marrow‐derived mesenchymal stem cells by activating FoxD3/microRNA‐496 to repress wnt signaling

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