The association of incident dementia with mortality in PD

Levy, Gilberto; Tang, Mingxin; Louis, Elan D.; Côté, Lucien J.; Alfaro, B.; Mejía, H.; Stern, Yaakov; Marder, Karen

doi:10.1212/01.wnl.0000036610.36834.e0

Cited by 269 publications

(168 citation statements)

References 62 publications

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“…In accordance to one study 10 (but not another 2 ), we found an association between bradykinesia and poor functional outcomes. As in our study, previous research has found gait disorder to be associated with increased mortality in patients with PD 37 and even in nondemented elderly. 38 Postural and gait The models of the 1st and 2nd row included total motor signs sum score as time-dependent predictor.…”

supporting

confidence: 87%

Man-in-the-barrel syndrome caused by a pontine lesion

Paulin¹,

Seze²,

Wyremblewski³

et al. 2005

Neurology

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Abstract-Objective:To examine whether the presence of motor signs has predictive value for important outcomes in Alzheimer disease (AD). Methods: A total of 533 patients with AD at early stages (mean Folstein Mini-Mental State Examination [MMSE] 21/30 at entry) were recruited and followed semiannually for up to 13.1 years (mean 3) in five University-based AD centers in the United States and European Union. Four outcomes, assessed every 6 months, were used in Cox models: cognitive endpoint (Columbia Mini-Mental State Examination Յ 20/57 [‫ف‬MMSE Յ 10/30]), functional endpoint (Blessed Dementia Rating Scale Ն 10), institutionalization equivalent index, and death. Using a standardized portion of the Unified PD Rating Scale (administered every 6 months for a total of 3,149 visit-assessments, average 5.9 per patient), the presence of motor signs, as well as of individual motor sign domains, was examined as time-dependent predictor. The models controlled for cohort, recruitment center, sex, age, education, a comorbidity index, and baseline cognitive and functional performance. Results: A total of 39% of the patients reached the cognitive, 41% the functional, 54% the institutionalization, and 47% the mortality endpoint. Motor signs were noted for 14% of patients at baseline and for 45% at any evaluation. Their presence was associated with increased risk for cognitive decline (RR, 1.72; 95% CI, 1.24 to 2.38), functional decline (1.80 [1.33 to 2.45]), institutionalization (1.68 [1.26 to 2.25]), and death (1.38 [1.05 to 1.82]). Tremor was associated with increased risk for reaching the cognitive and bradykinesia for reaching the functional endpoints. Postural-gait abnormalities carried increased risk for institutionalization and mortality. Faster rates of motor sign accumulation were associated with increased risk for all outcomes. Conclusions: Motor signs predict cognitive and functional decline, institutionalization, and mortality in Alzheimer disease. Different motor sign domains predict different outcomes.

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supporting

confidence: 87%

Man-in-the-barrel syndrome caused by a pontine lesion

Paulin¹,

Seze²,

Wyremblewski³

et al. 2005

Neurology

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“…Furthermore, NCDs are a common illness in the elderly, and they represent one of the most important factors in disability and mortality (2). The prevalence of NCDs is estimated to range from 2% to 8% in the elderly population (3).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Zinc and Cognitive Impairment in Elderly People of Iran

et al. 2017

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“…6 Furthermore, the impact of MCI and dementia in pa-tients with PD at any given stage of the disease is substantial, with adverse consequences for functioning, 7 psychiatric morbidity, caregiver burden, 8 and mortality. 9 At present, there is much to be elucidated with regard to the etiology of cognitive impairment in PD. Initially, dementia in PD was described as subcortical.…”

mentioning

confidence: 99%