The association of physical activity and sedentary lifestyle with asthma in childhood

Vlashki, Emilija; Cholakovska, Valentina Cvejoska; Kimovska, Mica; Seckova, Lidija; Ristevska, Tara; Lawson, Joshua

doi:10.1183/13993003.congress-2018.pa4603

Cited by 2 publications

(2 citation statements)

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“…It is demonstrated that reduced exercise increases asthma morbidity [53]. Also, childhood asthma has been associated with a sedentary lifestyle [54]. Moreover, aerobic exercise training has potential to improve asthma control and lung function in adults with asthma [55].…”

Section: Environmental Exposures Impacting Chronic Respiratory Diseasesmentioning

confidence: 99%

Exposome mapping in chronic respiratory diseases: the added value of digital technology

Goossens

Bullens

Dupont

et al. 2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewThe development and progression of chronic respiratory diseases are impacted by a complex interplay between genetic, microbial, and environmental factors. Here we specifically summarize the effects of environmental exposure on asthma, allergic rhinitis, and chronic rhinosinusitis. We furthermore discuss how digital health technology may aid in the assessment of the environmental exposure of patients and how it may be of added value for them. Recent findingsIt is well established that one gets allergic symptoms if sensitized and exposed to the same allergen. Viruses, bacteria, pollutants, irritants, and lifestyle-related factors modify the risk of getting sensitized and develop symptoms or may induce symptoms themselves. Understanding these processes and how the various factors interact with each other and the human body require big data and advanced statistics. Mobile health technology enables integration of multiple sources of data of the patients' exposome and link these to patient outcomes. Such technologies may contribute to the increased understanding of the development of chronic respiratory disease.

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Section: Environmental Exposures Impacting Chronic Respiratory Diseasesmentioning

confidence: 99%

Exposome mapping in chronic respiratory diseases: the added value of digital technology

Goossens

Bullens

Dupont

et al. 2021

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

show abstract

“…Many environmental factors, such as BMI ( Taylor et al, 2008 ), smoking ( Hedman et al, 2011 ), physical inactivity ( Cordova et al, 2017 ; Vlashki et al, 2018 ), and dietary habits ( Protudjer et al, 2012 ), have been epidemiologically and clinically related to the occurrence or severity of asthma. But, observational studies encounter limitations in determining a causal link, due to their various potential confounding factors ( Sun et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Environmental Factors and Asthma Using Mendelian Randomization: Increased Effect of Body Mass Index on Adult-Onset Moderate-to-Severe Asthma Subtypes

Jung

Kim

et al. 2021

Front. Genet.

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Although asthma is one of the most common chronic diseases throughout all age groups, its etiology remains unknown, primarily due to its heterogeneous characteristics. We examined the causal effects of various environmental factors on asthma using Mendelian randomization and determined whether the susceptibility to asthma due to the causal effect of a risk factor differs between asthma subtypes, based on age of onset, severity of asthma, and sex. We performed Mendelian randomization analyses (inverse variance weighted, weighted median, and generalized summary-data-based Mendelian randomization) using UK Biobank data to estimate the causal effects of 69 environmental factors on asthma. Additional sensitivity analyses (MR-Egger regression, Cochran’s Q test, clumping, and reverse Mendelian randomization) were performed to ensure minimal or no pleiotropy. For confirmation, two-sample setting analyses were replicated using BMI SNPs that had been reported by a meta-genome-wide association study in Japanese and European (GIANT) populations and a genome-wide association study in control individuals from the UK Biobank. We found that BMI causally affects the development of asthma and that the adult-onset moderate-to-severe asthma subtype is the most susceptible to causal inference by BMI. Further, it is likely that the female subtype is more susceptible to BMI than males among adult asthma cases. Our findings provide evidence that obesity is a considerable risk factor in asthma patients, particularly in adult-onset moderate-to-severe asthma cases, and that weight loss is beneficial for reducing the burden of asthma.

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The association of physical activity and sedentary lifestyle with asthma in childhood

Cited by 2 publications

References 0 publications

Exposome mapping in chronic respiratory diseases: the added value of digital technology

Exposome mapping in chronic respiratory diseases: the added value of digital technology

Association Between Environmental Factors and Asthma Using Mendelian Randomization: Increased Effect of Body Mass Index on Adult-Onset Moderate-to-Severe Asthma Subtypes

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