The association of severity of retinal vascular changes and cardiac remodelling in systemic hypertension

Varghese, Mary; Adhyapak, Srilakshmi M.; Thomas, Tinku; Sunder, Meera; Varghese, Kiron

doi:10.1177/1753944716630869

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…In the bivariate analysis, it was stated that there was no significant relationship between blood pressure and the severity of DR (p = 1,000). This is in line with the research conducted by Varghese et al (2016) which stated that blood pressure, especially systolic TD did not show a significant positive correlation with the severity of DR (33) . Well-controlled control of glycemic and Hypertension levels has been clinically proven to reduce the risk of macrovascular and microvascular complications in patients with T2DM (34) .…”

Section: Association Of Patient Characteristics To Severity Of Diabet...supporting

confidence: 92%

Patient Characteristics and Prevalence of Single Nucleotide Polymorphism (SNP) V16A MnSOD Gene in Diabetic Retinopathy Patients at RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali

2023

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Diabetic Retinopathy (DR) is a microvascular complication of Diabetes Mellitus (DM) caused by hyperglycemia and oxidative stress that is prevalent to the blindness risk. Manganese superoxide dismutase (MnSOD) gene affect the oxidative damage and progression of DR severity. This study aims to determine the association of patient characteristics on the severity and prevalence of Single Nucleotide Polymorphism (SNP) V16A in the MnSOD gene in DR patients at Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali. Twelve (12) subjects with Non-Proliferative DR and 21 subjects with Proliferative DR were enrolled. Patient characteristics (age, T2DM duration, BMI, blood pressure) were associated to the DR severity using cross-sectional analytic study. While to detect the status of the SNP V16A MnSOD gene using descriptive experimental study. DNA segment amplification was performed using the PCR method, sequencing was performed to detect the base pattern at the location of the SNP. A domination of the VV genotype in the SNP V16A MnSOD gene was present in all subjects (100%). The majority of subjects were female (51,5%), age range 40-65 years (84,9%), T2DM duration <10 years (60,6%), normal BMI (60,6%). Blood pressure was dominated with non hypertension 60,6%, with a history of oral anti hypertensive. No significant association was found between patient characteristics and the DR severity (p<0,05). We may conclude that wildtype variant (VV) SNP V16A MnSOD gene was dominated in this finding. There is no significant association between patient characteristics and the severity of DR in Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali. Keywords: Diabetic Retinopathy, MnSOD gene, SNP V16A

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Section: Association Of Patient Characteristics To Severity Of Diabet...supporting

confidence: 92%

Patient Characteristics and Prevalence of Single Nucleotide Polymorphism (SNP) V16A MnSOD Gene in Diabetic Retinopathy Patients at RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali

2023

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“…Numerous groups report an increased media-to-lumen (M/L) ratio in small subcutaneous resistance arteries collected during a gluteal biopsy 30,31 . More recently developed non-invasive techniques, including microscopic and clinical analysis of the retinal vascular bed, confirm findings of increased M/L ratio and highlight novel non-invasive tools for diagnosing pathophysiological vascular changes in hypertension 32,33 .…”

Section: Clinical Relevancementioning

confidence: 73%

“…Hypertensive patients have significantly increased wall-to-lumen ratio in retinal arterioles compared to normotensive controls as measured using scanning laser Doppler flowmetry 32 . Similarly, hypertensive patients with advanced microvascular retinal damage (retinopathy) have a higher incidence of left atrial enlargement, reduced left ventricular ejection fraction, and consequently congestive heart failure 33 . Comparison of resistance arteries from the forearm and coronary microvasculatures suggests that these two parameters are remodeled in parallel in untreated patients with mild hypertension 34 .…”

Section: Clinical Relevancementioning

confidence: 99%

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Brown

Diederich

Good

et al. 2018

ATVB

185

134

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Cardiovascular disease is a leading cause of death worldwide and accounts for greater than 17.3 million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 1. Cardiovascular death represents 31% of all global deaths 2 - with stroke, heart attack, and ruptured aneurysms predominantly contributing to these high mortality rates. A key risk factor for cardiovascular disease is hypertension. Although treatment or reduction in hypertension can prevent the onset of cardiovascular events, existing therapies are only partially effective. A key pathological hallmark of hypertension is increased peripheral vascular resistance due to structural and functional changes in large (conductive) and small (resistance) arteries. In this review, we discuss the clinical implications of vascular remodeling, compare the differences between vascular smooth muscle cell (VSMC) remodeling in conductive and resistance arteries, discuss the genetic factors associated with VSMC function in hypertensive patients, and provide a prospective assessment of current and future research and pharmacological targets for the treatment of hypertension.

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“…Обнаруженные в общей когорте обследованных лиц слабые, но достоверные корреляции значений ЦАЭС с индексом объёма ЛП (отрицательная ассоциация), значений ЦВЭС с амплитудой зубца R в отведении aVL (положительная ассоциация), а также выявленная в мужской выборке прямая взаимосвязь значений ЦВЭС и Корнельского вольтажного произведения, в целом поддерживают результаты других авторов, установивших в перекрестных и проспективных исследованиях отчётливо большую вероятность наличия ультразвуковых признаков дилатации левых камер сердца, а также ЭКГкритериев ГЛЖ именно у тех субъектов, которые характеризовались присутствием офтальмоскопических микроваскулярных изменений сетчатки [11].…”

Section: Discussionunclassified

“…Среди лиц с начальными стадиями гипертензивной ретинопатии частота встречаемости ЭКГкритериев ГЛЖ составляет приблизительно 10% [11]. В реальной клинической практике вероятность выявления ЭКГ-критериев ГЛЖ стремительно возрастает в случае наличия признаков злокачественной АГ, одним из которых служит картина геморрагий или отёка диска зрительного нерва [12].…”

Section: Discussionunclassified

Gender characteristics of retinal parameters in patients with uncomplicated hypertension

Барсуков

Shcherbakova

Burnasheva

et al. 2020

Cardiovasc Ther Prev

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Aim. To establish gender specificities of retinal arteriolar and venular diameters, foveal avascular zone (FAZ) area, subfoveal choroid thickness (SCT), and to determine their association with cardiovascular risk and prognosis in patients with uncomplicated hypertension (HTN).Material and methods. The study included 70 patients (56 males and 14 females) aged 45-59 years with stage I or II HTN. There were following exclusion criteria: diabetes, liver failure, clinically relevant ophthalmic pathology. We assessed routine hemodynamic parameters, biochemical profile, serum N-terminal procollagen-III peptide, urinary albumin-creatinine ratio, 24-hour urinary albumin excretion, retinal parameters. All patients underwent electrocardiography and echocardiography. Ten-year risk of fatal cardiovascular disease (SCORE) was estimated. Based on scanning laser ophthalmoscopy, central retinal arterial (CRAE) and venous (CRVE) equivalents, arteriovenous ratio (AVR) were calculated. Using optical coherence tomography angiography, we determined FAZ area and SCT. Data processing was performed using StatSoft Statistica 10.Results. Hypertensive women were characterized by significantly larger FAZ area (p<0,001), CRVE (p=0,005), CRAE (p=0,012) compared with men. SCT values (p>0,05) were comparable. CRVE was associated with Cornell voltage product (r=0,3) in the male group. In women, age was negatively correlated with SCT (r=-0,54); SCORE value was inversely associated with SCT (r=-0,56), AVR (r=-0,53), CRAE (r=-0,3).Conclusion. In patients with uncomplicated HTN, the gender specificities of retina are manifested by a relative decrease of arteriolar diameters in males and a relative increase of venular diameters and FAZ in females. SCT decreases most clearly with age among hypertensive women. Men are characterized by a direct association of retinal venular diameters with a quantitative electrocardiographic marker of left ventricular hypertrophy. In women, there are an inverse association of SCT and arteriolar diameters with a ten-year risk of fatal cardiovascular disease.

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The association of severity of retinal vascular changes and cardiac remodelling in systemic hypertension

Cited by 9 publications

References 29 publications

Patient Characteristics and Prevalence of Single Nucleotide Polymorphism (SNP) V16A MnSOD Gene in Diabetic Retinopathy Patients at RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali

Patient Characteristics and Prevalence of Single Nucleotide Polymorphism (SNP) V16A MnSOD Gene in Diabetic Retinopathy Patients at RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar Bali

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension

Gender characteristics of retinal parameters in patients with uncomplicated hypertension

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