The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo

Li, K.; Shi, Qiong; Yang, Longfei; Li, X.; Liu, L.; Wang, L.; Li, Q.; Wang, G.; Li, C.‐Y.; Gao, Tianwen

doi:10.1111/j.1365-2133.2012.11132.x

Cited by 74 publications

(101 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, studies on relationships between Pb and serum 25(OH)D are few; most were done more than two decades ago when BLL were much higher ($29 mg/dl) and have yielded inconsistent results (17)(18)(19)(20)(21) . (22,23) . Hence, with the improvement of the environment and prevention measures for Pb exposure, a new relationship between vitamin D and BLL that is lower than in the past should be established.…”

Section: The Concentration Of 25-hydroxyvitamin D (25(oh)d)mentioning

confidence: 99%

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Liu

Shi

et al. 2013

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To evaluate the prevalence of vitamin D deficiency and insufficiency, as well as their association with Hb and elevated blood lead levels (BLL) in children in China. Design: A cross-sectional and 1-year retrospective study. Setting: Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, China. Subjects: Children aged from 6 months to 14 years living in south-west China who were taken to physical examinations (January-December 2011). Results: Of 1218 children included in the study, 25-hydroxyvitamin D (25(OH)D) concentration (mean 33?18 (SD 16?48) ng/ml) was deficient in 21?6 % and insufficient in 27?4 %, which were higher than the prevalence of both anaemia at 8?5 % and elevated BLL (Pb $ 10 mg/dl) at 1?8 %, but lower than mildly elevated BLL prevalence (5 mg/dl # Pb , 10 mg/dl) at 56?9 %. There was a negative correlation between 25(OH)D concentration and BLL (r 5 20?216, P , 0?001) while no significant relationship was found between 25(OH)D concentration and Hb (r 5 20?012, P . 0?05). After multivariable adjustment, the significant predictors of 25(OH)D deficiency and insufficiency were increasing child age especially between 8 and 14 years (OR 5 18?29; 95 % CI 10?14, 32?99; P , 0?001) and BLL (OR 5 1?01; 95 % CI 1?00, 1?02; P 5 0?045). Conclusions: The prevalence of 25(OH)D deficiency and insufficiency was much higher than that of anaemia or elevated BLL in south-west China, and associated with increasing age and BLL.

show abstract

Section: The Concentration Of 25-hydroxyvitamin D (25(oh)d)mentioning

confidence: 99%

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Liu

Shi

et al. 2013

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…[12][13][14][15][16][17][18][19][20] There was no significant decrease in vitamin D levels in patients with associated autoimmune comorbidity in our study. Similar results have been found by Khurrum et al, Saleh et al as well as Beheshti et al 7,18,19 All other studies had found a significant decrease in vitamin D levels in patients having comorbid autoimmune conditions.…”

Section: Discussionmentioning

confidence: 89%

“…Similar results were obtained in a study by Finamor et al as well as Takczi et al 9,11 However the majority of patients in other studies had a mean age below 35. [6][7][8][12][13][14][15][16][17][18][19][20] This may reflect certain social attitudes towards the disease i.e. hesitancy to consult local physicians regarding vitiligo, or presenting to a tertiary center only after prolonged native treatment.…”

Section: Discussionmentioning

confidence: 99%

A case control study of vitamin D levels in patients with vitiligo

Karthikeyan

2017

Int J Res Dermatol

View full text Add to dashboard Cite

Background: Vitiligo is fairly commonly encountered disorder of pigmentation resulting in the presence of numerous depigmented macules and patches over the body. Vitamin D is an essential hormone synthesized in the skin. Levels of vitamin D have been found to be low in patients with vitiligo. The purpose of this study is to evaluate if vitamin D levels have any association with vitiligo, by estimating the levels of vitamin D in patients with vitiligo, and correlating type of vitiligo with vitamin D levels.Methods: A hospital based case control study was done in the Dermatology outpatient department of a tertiary center in South India from October 2014 to May 2016. About 45 consenting patients who fulfilled the inclusion criteria were chosen for the study. About 45 age and sex matched consenting individuals without vitiligo were chosen as controls from the Dermatology outpatient department. A detailed history and clinical examination of all the consenting subjects was done. Blood samples were collected from both the cases and controls by venepuncture and sera separated. The levels of Vitamin D were estimated using a vitamin D ELISA kit.Results: There was no statistically significant difference in vitamin D levels between patients and controls. There was no correlation between type of vitiligo and vitamin D value. Conclusions: Vitamin D does not appear to have any role in vitiligo patients in this study.

show abstract

“…Vitiligo and autoimmunity may be influenced by vitamin D and a recent Chinese study documents low levels of 25-hydroxy vitamin D in vitiligo 42 . Treatment with calcipotriol is a reminder of the role of vitamin D precursors 1,25(OH) 2 D, which even 500 million years ago protected primitive cellular organisms from environmental hazards, including ionizing and UV-irradiation, microbial infections and oxidative stress 43 .…”

Section: Lerner's Theory Of Self-destructionmentioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

View full text Add to dashboard Cite

Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

show abstract

The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo

Abstract: Our findings suggest that these VDR polymorphisms are associated with 25(OH)D levels and that there exists a genetic predisposition for vitiligo in the Chinese population.

Cited by 74 publications

References 37 publications

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

Association of 25-hydroxyvitamin D with Hb and lead in children: a Chinese population-based study

A case control study of vitamin D levels in patients with vitiligo

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Contact Info

Product

Resources

About