The biochemical mechanism of selective heat sensitivity of cancer cells—IV. Inhibition of RNA synthesis

Strom, Roberto; Santoro, Antonio; Crifò, C; Bozzi, Argante; Mondovı̀, Bruno; Fanelli, A.

doi:10.1016/0014-2964(73)90079-0

Cited by 52 publications

(29 citation statements)

References 19 publications

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“…Since these cells have poor uptake 1 capacity and the elevated temperature-dependent enhnement of mIBG uptake was observed both in the presence and absence of the monoamine transport inhibitor DMI, the increased accumulation of mIBG at 39-C seems to involve non-specific uptake mechanisms. A similar effect of temperature elevation has been noted for passive molcular transport (Strom et al, 1973) in Ehrlic ascitic tumour cells. These exhibit an exponential increase in passive diffusion of radiolabelled uridine across the cell membrane with increasng temperature.…”

Section: Resktssupporting

confidence: 73%

Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature

Armour

Mairs²,

Gaze³

et al. 1994

Br J Cancer

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SummarySuccessful imaging or treatment of neuroblastoma With '3'I-meta-iodobenzy1guanidine depends on the selectivity of active (type 1) uptake of mIBG in neuroblastoma cells relative to passive (type 2) uptake present in most normal tissues. This study investigates the effects of moderately elevated temperature (39-41'C) on the cellular uptake of '3'I-mIBG in two neuroblastoma cell lines [SK-N-BE(2c) and and in a non-neuronal (ovarian carcinoma) cell line (A2780). In SK-N-BE(2c), a cell line with high active uptake capacity. the specific (type 1) uptake was reduced by 75% (P<0.001) at 39"C. Both IMR-32 and A2780 have a low capacity for accumulation of mIBG by active uptake. These cell lines demonstrated a statistically significant increase in accumulation at 39C, mainly as a result of increased non-specific transport.At 41°C uptake of "3'I-mIBG was reduced in all cell lines. Thus, the active component of mIBG uptake is more vulnerable to increased temperature than the passive component. It seems probable that moderately increased temperature will have an unfavourable effect on the therapeutic differential for targeted radiotherapy of neuroblastoma using radiolabelled mIBG.

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Section: Resktssupporting

confidence: 73%

Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature

Armour

Mairs²,

Gaze³

et al. 1994

Br J Cancer

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“…This up-regulation of HSPs leads to a well-known phenomenon, known as thermo-tolerance [11]. Consequently, findings from prior work justify investigating new pulsed heating regiments that would allow sufficient time for the thermo resistance to subside while taking advantages of cell cycle disruptions [8,13,14].…”

Section: Introductionmentioning

confidence: 98%

“…Heat causes a cellular stress which triggers a cascade of molecular events. Studies have shown that heat affects nuclear function through the inhibition of RNA [12][13][14][15], DNA [16,17], and protein synthesis [16][17][18]. In addition, hyperthermia causes delay or arrest in cell cycle progression [19]; chiefly through mitotic arrest [20][21][22][23] and inhibiting S phase entry from G 2 [24,25].…”

Section: Introductionmentioning

confidence: 99%

An in-vitro study of the effects of temperature on breast cancer cells: Experiments and models

Theriault

Paetzell

Chandrasekar

et al. 2012

Materials Science and Engineering: C

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“…Noteworthy, the delay to recover protein synthesis corresponds to the onset of thermotolerance [107][108][109].…”

Section: Introductionmentioning

confidence: 99%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

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Hyperthermia, an established adjuvant in cancer treatment, potentiates the effects of anticancer drugs and synergetic combination can be obtained improving the therapeutic outcome. Bone metastases may benefit from this combination when treated through in situ forming implants. Once loaded with magnetizable (nano-) particles and antineoplastic agents, these implants allow for the local application of magnetically-induced hyperthermia and the release of an anticancer drug. The implant can be heated applying an external magnetic field, sensitizing the surrounding tumoral tissues, while releasing the chemotherapeutic agent.Moreover, bone implants provide mechanical support to the weakened bone and consequently relieve pain.This review gives an overview of the current knowledge as well as the rationale of combining locally both magnetic hyperthermia and chemotherapy using in situ forming implants in the field of bone metastases treatment. KeywordsInduced hyperthermia, chemotherapy, drug delivery systems, in situ forming implants, iron oxide nanoparticles, bone metastases, cementoplasty, vertebroplasty 3

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The biochemical mechanism of selective heat sensitivity of cancer cells—IV. Inhibition of RNA synthesis

Cited by 52 publications

References 19 publications

Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature

Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature

An in-vitro study of the effects of temperature on breast cancer cells: Experiments and models

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

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