The Blood Groups and Secretor Types in Five Potentially Fatal Diseases of Caucasian Children

Gershowitz, Henry; Neel, James V.

doi:10.1159/000151919

Cited by 8 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have conducted two other studies which yield data on the frequency of extramarital conceptions among children born in the state of Michigan. In an analysis of a series of nuclear families from the lower portion of the state of Michigan, studied between 1956 and 1964 because of the occurrence of a potentially lethal disease in a child (Gershowitz and Neel, 1965), Schacht and Gershowitz (1963) calculated that 1.48 _+ 0.32% of 1417 Caucasoid children were conceived extramaritally, the corresponding figure for 523 Black children being 9.94 _4-1.31%. In a second study which involved a large series of typings of blood samples drawn in 1965 from Caucasoid individuals residing in a Michigan town with approximately 10000 inhabitants, we estimated that 3.82 _+ 0.34% of the children for whom there were typings on the nuclear family were conceived extramaritally (Sing et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

A pilot study of the use of placental cord blood samples in monitoring for mutational events

Neel

Mohrenweiser

Gershowitz

1988

Mutation Research/Genetic Toxicology

View full text Add to dashboard Cite

A pilot study exploring the examination of placental cord blood samples for mutant proteins with one-dimensional electrophoretic techniques is described. Although technical advances are such that the techniques employed in this study are now partially superceded, the practical problems encountered in this study would be typical of any monitoring program of this type. No mutations altering electrophoretic mobility among a battery of 51 different locus products were encountered in a total of 277,747 locus tests. When these data are combined with similar data from other studies, the mutation rate for electromorphs becomes 0.34 X 10(-5)/locus/generation.

show abstract

Section: Discussionmentioning

confidence: 99%

A pilot study of the use of placental cord blood samples in monitoring for mutational events

Neel

Mohrenweiser

Gershowitz

1988

Mutation Research/Genetic Toxicology

View full text Add to dashboard Cite

show abstract

“…More recent work by Edwards, Ferguson & Coombs (1964), Boettcher (1965) and Parish, Carron-Brown & Richards (1967) denies the presence of ABO antigens on the spermatozoa of nonsecretors of ABO blood group substances. However, about three-quarters of populations tested are secretors (Gershowitz & Neel, 1965). Hence spermatozoa of such males with attached ABO antigens could be exposed to possible selective effects of cervical haemagglutinin in ABO-incompatible women producing these agglutinins.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Abo Isohaemagglutinins Among Fertile and Infertile Women

Solish¹

1969

Reproduction

View full text Add to dashboard Cite

The frequency of occurrence and the titres of cervical mucus isoagglutinins were determined in a group of 204 infertile women and compared to those in 82 fertile women from approximately the same parent population. Cervical agglutinins were found more frequently among fertile women than among infertile women, the reverse of that which would be expected if these agglutinins were involved in the establishment of a deficiency of A and B children among ABO-incompatible matings. Data from an additional 1403 Negro, Puerto Rican and Caucasian women showed that the frequency of occurrence and the titres of cervical isoagglutinins varied with ethnic origin and ABO blood type of the subject but not with Rh, or MN blood types. Negro women had cervical agglutinins more frequently and in higher titres than Caucasian or Puerto Rican women while Puerto Rican women had the highest serum titres of isohaemagglutinins. Type O women of all ethnic groups have higher titres as well as more frequent occurrence of cervical agglutinins than type A or type B women of the same ethnic group. No relationship between age and the occurrence of cervical agglutinins was found but, among women who have cervical agglutinins, age does have a significant effect on the titre.Season of the year and phase of the menstrual cycle have little or no effect on the presence of anti-A or anti-B agglutinins in the cervical secretions. If cervical agglutinins play any role in the process of fertilization it is a more complex one than previously supposed. The evidence presented here makes it unlikely that cervical haemagglutinins can, by prezygotic selection, account for the reported 25% deficit of blood type A and/or B children among ABO-incompatibly mated parents.

show abstract

“…In a subsequent analy sis of these data, Chung et al (57) found no evidence that heterozygous secretors have a greater susceptibility than homozygous secretors. Ger showitz & N eel confirmed the association of nonsecretion and rheumatic heart disease in a carefully conducted study, but they were unable to verify the smaller blood group a frequency reported among such patients (113).…”

Section: Disease Associations With Genetic Markersmentioning

confidence: 92%

Untitled

1967

Annu. Rev. Genet.

View full text Add to dashboard Cite

On April 5, 1967, as this first volume of the Annual Review of Genetics was being prepared for publication, H. J. Muller died. The Editorial Com mittee had hoped to include a chapter written by him, but his other commit ments and failing health made this impossible. An appreciation of Dr. Muller and his work, written by G. Pontecorvo, is planned for Volume II.We remember Dr. Muller for his ingenuity in divising new experimental methods, his imaginative theoretical insights, and his ability and willingness to look far beyond the immediate implications of an experiment or idea. We also remember his strong convictions, his confidence in the social benefi ts of science and of genetics in particular, his intellectual and moral courage, and his undeviating adherence to principle. Those who knew Joe Muller per sonally remember his great intellect, his driving energy, his sympathy for mankind in the large, his sense of human dignity, and his zest for new knowledge.To H. J. Muller we dedicate this first volume of the Annual Review of Genetics. The influence of his ideas is abundantly apparent throughout the book.

show abstract

The Blood Groups and Secretor Types in Five Potentially Fatal Diseases of Caucasian Children

Cited by 8 publications

References 11 publications

A pilot study of the use of placental cord blood samples in monitoring for mutational events

A pilot study of the use of placental cord blood samples in monitoring for mutational events

Distribution of Abo Isohaemagglutinins Among Fertile and Infertile Women

Untitled

Contact Info

Product

Resources

About