Distribution of Abo Isohaemagglutinins Among Fertile and Infertile Women

Abstract

The frequency of occurrence and the titres of cervical mucus isoagglutinins were determined in a group of 204 infertile women and compared to those in 82 fertile women from approximately the same parent population. Cervical agglutinins were found more frequently among fertile women than among infertile women, the reverse of that which would be expected if these agglutinins were involved in the establishment of a deficiency of A and B children among ABO-incompatible matings. Data from an additional 1403 Negro, Puerto Rican and Caucasian women showed that the frequency of occurrence and the titres of cervical isoagglutinins varied with ethnic origin and ABO blood type of the subject but not with Rh, or MN blood types. Negro women had cervical agglutinins more frequently and in higher titres than Caucasian or Puerto Rican women while Puerto Rican women had the highest serum titres of isohaemagglutinins. Type O women of all ethnic groups have higher titres as well as more frequent occurrence of cervical agglutinins than type A or type B women of the same ethnic group. No relationship between age and the occurrence of cervical agglutinins was found but, among women who have cervical agglutinins, age does have a significant effect on the titre.Season of the year and phase of the menstrual cycle have little or no effect on the presence of anti-A or anti-B agglutinins in the cervical secretions. If cervical agglutinins play any role in the process of fertilization it is a more complex one than previously supposed. The evidence presented here makes it unlikely that cervical haemagglutinins can, by prezygotic selection, account for the reported 25% deficit of blood type A and/or B children among ABO-incompatibly mated parents.

Maternal fetal interaction in the ABO system: A comparative analysis of healthy mother and couples with spontaneous abortion in Bengalee population

“…Incidences of couple combinations for ABO blood groups among the parents of the abortus fetus and the parents of the newborns as presented in the Table 4, indicated significantly higher ( P < 0.05) incidences of ABO incompatibility among the aborted couples (48.53%) compared to that of the parents of the newborns (29.84%), which is well within the range of published work on Bengalee population (Banerjee and Das,1986; Bandyopadhyay,1992a,b; Bandyopadhyay,1993). The effect of fetal wastage and the incidences of couple combination for ABO incompatibility were found to be in well agreement with the non‐Indian (Solish,1969; Clegg,1979; Bottini and Santeusanio,1998; Bottini et al,2001), Indian samples (Jindal and Basu,1981; Sharma and Kapoor,2004), and Bengalee population samples (Banerjee and Das,1986; Bandyopadhyay,1992a,b).…”

“…Three principles but not mutually exclusive mechanism such as mortality of the genotype (Levine,1943; Weiner,1942; Aird et al,1953; Bandyopadhyay,1992a,b; Bottini et al,2001), distortion of segregation ratios (Hirzfeld and Zoborowski,1925; Kirk et al, 1955; Bottini et al,1998; Banerjee and Das,1986; Virdhi and Kaur,1998) and differential fertility of different genotypes (Matsunaga and Etoh,1958; Matsunaga and Hiraizumi,1962; Nag and Banerjee,1976; Schaap et al,1984; Berberovic et al,2004) were thought to be responsible for the maintenance of polymorphism (Solish,1969; Cavalli‐Sfroza and Bodmer,1971; Chester and Olsson,2001) in ABO blood group as genetic marker traits and as well as multiple polymorphisms in noncoding regions (Seltsam et al,2003). A number of studies worldwide (Levine and Rosenfield,1961; Hirazumi et al,1973; Gualtieri et al,1985; Bottini et al,2001) as well as in India (Chakravartti and Chakravartti,1978; Satyanarayana et al, 1998; Banerjee,1989; Bandyopadhyay,1992a,b; Bandyopadhyay and Ghoshal Roy,2002; Sharma and Kapoor,2004) on ABO blood groups with regard to the operational processes for selection has been demonstrated.…”

Distribution of ABO blood group among fertile and infertile males in central India: a pilot study

“…Similar studies conducted by Cantuaria, [8] Schwimmer et al, [9] and Omu et al [10] showed no significant relation between ABO blood group antigens and infertility. Solish and Gershowitz [4] reported that there is no any relation between blood groups in husbands and wives of infertile and fertile group. [4] Similarly, Lurie et al [11] demonstrated that the association of the Lewis blood group with infertility in among groups was not statistically different, but Khan et al [6] found strong relation between blood group O and male infertility.…”

Genetics of obstetrical variables. A study from the collaborative perinatal project*

“…Our data could be consistent with this proposition, since we did not separate the three distinct classes of sister-in-law. ABO and other blood group incompatibilities have been implicated in spontaneous abortion by Cohen & Sayre (1968), Newcombe (1963), Peritz (1971) and Takano & Miller (1972); but Reed (1968), Rowley et al (1963), Solish (1969) and Solish & Gershowitz (1969) are not in agreement. Green & Urbach (1968) report definite absence of antibodies to placental trophoblast in maternal sera; they did not confirm the earlier report by Hulka et al (1961).…”