The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

Forlani, Gabriele; Giorda, Carlo; Manti, Roberta; Mazzella, Natalia; Cosmo, Salvatore De; Rossi, Maria Chiara; Nicolucci, Antonio; Bartolo, Paolo Di; Ceriello, Antonio; Guida, Pietro

doi:10.1155/2016/2931985

Cited by 79 publications

(66 citation statements)

References 32 publications

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“…Other complications of diabetes include liver diseases that are mainly caused by insulin resistance and oxidative stress (Bouderba et al ., ). Two hepatic complications are largely present in patients with diabetes: (i) concomitant autoimmune hepatitis (Matsumoto et al ., ) and (ii) NAFLD (Forlani et al ., ). A study of 118 diabetic patients found a prevalence of 24.5% of concomitant autoimmune hepatitis in diabetic patients (Matsumoto et al ., ).…”

Section: Hepatopathymentioning

confidence: 97%

Effects of Silymarin on Diabetes Mellitus Complications: A Review

2017

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Diabetes mellitus is a common metabolic disorder that is caused by a deficit in the production of (type 1) or response to (type 2) insulin. Diabetes mellitus is characterized by a state of chronic hyperglycemia and such symptoms as weight loss, thirst, polyuria, and blurred vision. These disturbances represent one of the major causes of morbidity and mortality nowadays, despite available treatments, such as insulin, insulin secretagogues, insulin sensitizers, and oral hypoglycemic agents. However, many efforts have been made to discover new drugs for diabetes treatment, including medicinal plant extracts. Silymarin is a powder extract of the seeds from Silybum marianum, a plant from the Asteraceae family. The major active ingredients include four isomers: silybin, isosilybin, silychristin, and silydianin. Silymarin is indicated for the treatment of hepatic disorders, such as cirrhosis, chronic hepatitis, and gallstones. Moreover, several studies of other pathologies, including diabetes, sepsis, osteoporosis, arthritis, hypercholesterolemia, cancer, viral infections, and Alzheimer's and Parkinson's diseases, have tested the effects of silymarin and reported promising results. This article reviews data from clinical, in vivo, and in vitro studies on the use of silymarin, with a focus on the complications of diabetes, including nephropathy, neuropathy, healing delays, oxidative stress, hepatotoxicity, and cardiomyopathy. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Hepatopathymentioning

confidence: 97%

Effects of Silymarin on Diabetes Mellitus Complications: A Review

2017

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“…Individuals with NAFLD have a ve times higher risk of developing diabetes [18,19]. The association between NAFLD and type 2 diabetes mellitus can be explained through insulin resistance, dyslipidemia, and accumulation of liver triglyceride in NAFLD and β-cell defect in type 2 diabetes mellitus [20].…”

Section: Study Subject Characteristicsmentioning

confidence: 99%

Correlation of Gut Firmicutes/Bacteroidetes Ratio with Fibrosis and Steatosis in Patients with Non-alcoholic Fatty Liver Disease

Jasirwan¹,

Muradi²,

Hasan³

et al. 2020

Preprint

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Background : We investigated the gut microbiota in patients with non-alcoholic fatty liver disease (NAFLD) and its correlation with fibrosis and steatosis as reflected in the controlled attenuation parameter and transient elastography valuesMethods : A cross-sectional study was performed on 37 patients with NAFLD at Cipto Mangunkusumo National General Hospital from December 2018 to March 2019. The gut microbiota was investigated in fecal samples with 16S RNA sequencing using the next-generation sequencing platform MiSeq (Illumina).Results : NAFLD was more common in patients with metabolic syndrome. Firmicutes, Bacteroidetes, and Proteobacteria were the predominant phyla. Bacteroides was more dominant than Prevotella, contrary to the results in previous studies on normal populations in Indonesia. Microbiota dysbiosis was observed in most samples. The gastrointestinal microbiota diversity was significantly decreased in patients with NAFLD with high triglyceride levels and central obesity. The Firmicutes/Bacteroidetes ratio correlated with steatosis and obesity, whereas some other species in the lower taxonomy were mostly correlated with steatosis and obesity without fibrosis. Proteobacteria is the only phylum strongly correlated with fibrosis in patients with normal body mass index.Conclusions : The gut microbiota diversity was decreased in patients with NAFLD with high triglyceride levels and central obesity, and certain gut microbes were correlated with fibrosis and steatosis.

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“…Most NAFLD patients have metabolic syndrome that refers to the metabolic disorder of protein, fat and carbohydrate in the body, causing the occurrence of hyperlipidemia, hyperglycemia and obesity. It is even closely associated with atherosclerotic cardio-cerebrovascular disease and extrahepatic malignant carcinoma (13,14). NAFLD is regarded as a disease that interacts with various diseases, not an isolated disease.…”

Section: Discussionmentioning

confidence: 99%

Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

et al. 2020

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This study investigated changes in the level of serum 25(OH)D] in patients with non-alcoholic fatty liver disease (NAFLD) and the correlation between the severity of NAFLD and 25(OH)D. A retrospective analysis was performed on 385 NAFLD patients (NAFLD group) admitted to the Zhongshan Hospital and 347 healthy people with physical examination (control group). The height and weight of all subjects were measured, and BMI was calculated. Fasting venous blood was extracted for the determination of blood glucose, blood lipid and 25(OH)D. The indicator levels of patients in the two groups were compared and analyzed. Spearman's correlation analysis was used to investigate the correlation between the severity of NAFLD and the level of 25(OH)D. The levels of BMI, FPG, FPI, HbA1c, TG, TC and LDL-C of patients in the NAFLD group were significantly higher than those in control group (P<0.05). The level of 25(OH)D in the NAFLD group was lower than that in control group (P<0.05). There was a significant negative correlation between 25(OH)D and the severity of patients in the NAFLD group (r=-0.868, P<0.001). BMI, FPG, FPI, HbA1c, TG, TC and LDL-C were independent risk factors for the low level of 25(OH)D (P<0.05). Lowly expressed in the serum of NAFLD patients, 25(OH)D has a significant negative correlation with the severity of NAFLD, which is of guiding significance for the prevention and treatment. 25(OH)D is a novel biomarker for NAFLD diagnosis and a potential drug target. Patients and methodsPatient data. A retrospective analysis was performed on 385 NAFLD patients admitted to the Zhongshan Hospital Affiliated to Xiamen University (Xiamen, China) from January 2015 to December 2017 and 347 healthy people with physical examination. There were 385 NAFLD patients in the NAFLD group, including 237 males and 148 females, aged

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The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes

Cited by 79 publications

References 32 publications

Effects of Silymarin on Diabetes Mellitus Complications: A Review

Effects of Silymarin on Diabetes Mellitus Complications: A Review

Correlation of Gut Firmicutes/Bacteroidetes Ratio with Fibrosis and Steatosis in Patients with Non-alcoholic Fatty Liver Disease

Correlation between serum 25‑OH vitamin D expression and non‑alcoholic fatty liver disease

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