The burden of pain in rheumatoid arthritis: Impact of disease activity and psychological factors

Vergne-Salle, Pascale; Pouplin, Sophie; Trouvin, Anne Priscille; Bera-Louville, A.; Soubrier, Martin; Richez, Christophe; Javier, R.-M.; Perrot, Serge; Bertin, Philippe

doi:10.1002/ejp.1651

Cited by 47 publications

(31 citation statements)

References 39 publications

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“…Our study also revealed that participation in social activities by patients with RA and SpA was negatively associated with inflammatory activity, as measured using DAS28 and BASDAI, respectively. This finding is consistent with those of other studies of RA, which found an association between increased inflammatory activity and pain, anxiety, depression, and quality of life [ 33 ]. In SpA, inflammatory activity measured using the BASDAI was also associated with greater depression, anxiety, and sleep disorders [ 3 ]; therefore, control of inflammation could improve these psychological factors, even participation in social activities.…”

Section: Discussionsupporting

confidence: 93%

Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study

et al. 2021

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Objectives: To compare the ability to participate in social activities among rheumatoid arthritis patients with other rheumatic disease patients and identify potentially implicated factors. Patients and methods: Between June and November 2019, we consecutively selected patients aged ≥18 years with RA (defined according to ACR/EULAR 2010), SpA (ASAS/EULAR 2010), and SLE (ACR 1997). Main outcome measures: Ability to participate in social roles and activities evaluated using the PROMIS score v2.0 short-form 8a (PROMIS-APS). Secondary outcomes: Participation in social activities according to a series of variables (mobility, depression, satisfaction with social relationships, social isolation, company, emotional support, instrumental support, and support via information). We evaluated the association between the ability to participate in social activities and associated variables using multivariable linear regression analysis. Results: The study population comprised 50 patients with RA (33.1%), 51 patients (33.8%) with SpA, and 50 patients (33.1%) with SLE. The mean PROMIS-APS scores were similar in the three groups. The multivariable analysis for the whole sample showed that the ability to participate in social activities was inversely associated with depression and directly with social satisfaction, mobility, company, and age. The stratified analysis revealed an inverse association between inflammatory activity and ability to participate in social activities in patients with RA and SpA, but not in those with SLE. Conclusion: All patients with RA, SpA, and SLE had a similar ability to participate in social activities. This was associated with other psychosocial factors (social satisfaction, mobility, company, depression) and clinical factors (age and inflammatory activity).

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Section: Discussionsupporting

confidence: 93%

Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study

et al. 2021

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“…In this study, we aimed to evaluate the impact of depression and anxiety assessed with STAI and BDI questionnaires on periodontal treatment outcomes. The French versions of STAI and BDI were selected due to their strong validation, reliability, internal consistency and extensive use in order to evaluate the association between psychological status and chronic diseases [38][39][40][41]. In a previous analysis where depression level was measured using the depression score of the DASS-42 self-administered questionnaire, an association between depression and worsened SRP outcomes was observed, especially regarding the evolution of BOP and reduction in deep sites with PPD > 5 mm and >7 mm [20].…”

Section: Discussionmentioning

confidence: 99%

Influence of Depression and Anxiety on Non-Surgical Periodontal Treatment Outcomes: A 6-Month Prospective Study

Petit

Anadon-Rosinach

Tuzin

et al. 2021

IJERPH

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Periodontal treatment could be worsened by risk factors. Depression and anxiety have been suggested as potentially influencing periodontal treatment outcomes. The aim of this study was to determine their association with non-surgical periodontal treatment outcomes in patients with generalized severe periodontitis (stage III/IV generalized periodontitis) at 6 months. A total of 68 patients diagnosed with generalized severe periodontitis were treated with scaling and root planing (SRP) and were followed at 3 and 6 months. The data of the 54 patients that followed the entire protocol were considered for analysis. Depression and anxiety levels were determined at baseline by the Beck Depression Inventory (BDI) and State-Trait Inventory (STAI) questionnaires. The association between psychological scores and periodontal parameters was evaluated by multivariate analysis. At 3 and 6 months, SRP induced an improvement for all periodontal parameters (plaque index (PI), bleeding on probing (BOP), periodontal probing depth (PPD) and clinical attachment loss (CAL)). BDI and STAI scores were associated with the evolution of PI, BOP, mean PPD and number of sites with PPD > 3 mm and with CAL > 3 mm. Depression and anxiety should be considered as risk factors for SRP and the identification of at-risk patients should be performed using well-established tools.

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“…Joint pain is a cardinal clinical feature of RA that significantly impacts quality of life 2 . Although RA pain is often thought to be of inflammatory origin, pain outcomes in RA can be poor despite optimal control of inflammation with current biologic therapies 3 . Therefore, new targeted therapies to effectively manage RA pain are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

miR-544-3p mediates arthritis pain through regulation of FcγRI

Liu

Jeon

2021

Preprint

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Chronic or episodic joint pain is a major symptom in rheumatoid arthritis (RA) and its adequate treatment represents an unmet medical need. However, the cellular and molecular mechanisms underlying RA pain remain elusive. Non-coding microRNAs (miRNAs) have been implicated in the pathogenesis of RA as negative regulators of the stability or translation of specific target mRNAs. Yet, their significance in RA pain is still not well defined. We and other groups recently identified neuronally expressed FcγRI as a key driver of arthritis pain in mouse RA models. Thus, we tested the hypothesis that miRNAs that target and regulate neuronal FcγRI attenuate RA pain. Here, we show that miR-544-3p was robustly downregulated whereas FcγRI was significantly upregulated in the dorsal root ganglion (DRG) in mouse RA models. Intrathecal injection of miR-544-3p mimic attenuated established mechanical and heat hyperalgesia in a mouse model of collagen II-induced arthritis (CIA). Moreover, this effect was likely mediated, at least in part, by FcγRI since miR-544-3p mimic downregulated FcγRI in the DRG during arthritis and genetic deletion of FcγRI produced similar antihyperalgesic effects in the CIA model. This notion was further supported by a dual luciferase assay showing that miR-544-3p targeted FcγRI by directly binding to its 3’UTR. In addition, FcγRI expression in DRG neurons in vitro was downregulated by miR-544-3p mimic and upregulated by miR-544-3p inhibitor. In naïve mice, miR-544-3p mimic alleviated acute joint pain hypersensitivity induced by IgG immune complex (IgG-IC), whereas miR-544-3p inhibitor potentiated the pro-nociceptive behavioral effect of IgG-IC. These findings suggest that miR-544-3p causally participates in the maintenance of arthritis pain by targeting neuronal FcγRI, and thus define miR-544-3p as a new potential therapeutic target for treating RA pain.

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The burden of pain in rheumatoid arthritis: Impact of disease activity and psychological factors

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 47 publications

References 39 publications

Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study

Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study

Influence of Depression and Anxiety on Non-Surgical Periodontal Treatment Outcomes: A 6-Month Prospective Study

miR-544-3p mediates arthritis pain through regulation of FcγRI

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