The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice

Gao, Bei; Chi, Liang; Tu, Pengcheng; Gao, Nan; Lü, Kun

doi:10.1021/acs.chemrestox.8b00179

Cited by 43 publications

(18 citation statements)

References 111 publications

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“…Evidence for this notion is provided by, for example, a recent report using an AD-like pathology with amyloid and neurofibrillary tangles (ADLPAPT) transgenic mouse model of AD [162], whereby transplantation of fecal microbiota from wild-type mice into ADLPAPT mice ameliorated plaque and NFT formation, reduced glial activation, and alleviated cognitive impairment [163]. A number of reports have now indicated that a wide range of pesticides, such as the fungicide propamocarb [164], glyphosate herbicides [165], carbamate insecticide Aldicarb [166], and Chlorpyrifos [167,168] are all known to alter gut microbiota and cause varying degrees of dysbiosis. Exposure of propamocarb to mice at 3-300 mg/L through drinking water for a duration of 28 days changed the microbiota in the cecal and fecal contents at phylum or genus levels [164].…”

Section: Dysfunction Of the Brain-gut Axismentioning

confidence: 99%

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Tang

2020

Toxics

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Environmental toxicants have been implicated in neurodegenerative diseases, and pesticide exposure is a suspected environmental risk factor for Alzheimer’s disease (AD). Several epidemiological analyses have affirmed a link between pesticides and incidence of sporadic AD. Meanwhile, in vitro and animal models of AD have shed light on potential neuropathological mechanisms. In this paper, a perspective on neuropathological mechanisms underlying pesticides’ induction of AD is provided. Proposed mechanisms range from generic oxidative stress induction in neurons to more AD-specific processes involving amyloid-beta (Aβ) and hyperphosphorylated tau (p-tau). Mechanisms that are more speculative or indirect in nature, including somatic mutation, epigenetic modulation, impairment of adult neurogenesis, and microbiota dysbiosis, are also discussed. Chronic toxicity mechanisms of environmental pesticide exposure crosstalks in complex ways and could potentially be mutually enhancing, thus making the deciphering of simplistic causal relationships difficult.

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Section: Dysfunction Of the Brain-gut Axismentioning

confidence: 99%

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Tang

2020

Toxics

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“…The structural integrity of the intestine guarantees functional tness for digestion, a fundamental process for nutrient absorption (Sun et al 2018). This process requires the presence of the intestinal microbiota, which is related to the stress response and can be affected even by pesticides (Gao et al 2018). Previous studies have shown that imidacloprid is capable of inducing microbiota dysbiosis in crabs (Hong et al 2020) and mice (Yang et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Toxicity and Genotoxicity of Imidacloprid in Tadpoles of Leptodactylus Latrans and Physalaemus Cuvieri (Anura: Leptodactylidae)

Cg¹,

Fa²,

Cf³

et al. 2021

Preprint

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Imidacloprid is a neonicotinoid insecticide widely used worldwide, but which can cause adverse effects on non-target organisms, especially in aquatic environments. This study aimed to evaluate the chronic toxicity of an insecticide-based imidacloprid in amphibians, using Leptodactylus latrans and Physalaemus cuvieri tadpoles. The parameters of survival, swimming activity, body size, damage to body structures and genotoxicity for both species were analyzed; and the ecological risk of this insecticide calculated. Chronic short-term assay was carried out for 168 h (7 days) and five concentrations of imidacloprid, between 3 and 300 µg L-1, were tested. The insecticide did not affect the tadpoles survival tadpoles; however, both species tested showed smaller body size, damage to the mouth and intestine and the induction of micronuclei and other erythrocytes nuclear abnormalities after exposure to imidacloprid-based herbicide. Insecticide exposure affected the swimming activity in L. latrans, which contributes to the greater sensitivity of L. latrans to imidacloprid when compared to P. cuvieri. All parameters analyzed indicated that the insecticide presents an ecological risk for both species at concentrations greater than 3 µg L-1. This demonstrates the genotoxicity of the insecticide imadacloprid, which can contribute to the population decline of L. latrans and P. cuvieri species in natural systems.

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“…Recent studies have documented the functional changes in the gut microbiome upon exposure to diverse xenobiotics (Table 1) [12][13][14][15]47,51,52,61,62,[66][67][68][69][70]76,[106][107][108][109]. Consistent changes in gut microbial profiles could be potential biomarkers of gut microbiome toxicity associated with specific chemical exposures.…”

Section: Biomarkers and Assessment Of Gut Microbiome Toxicitymentioning

confidence: 99%

Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases

Chi

Bodnar

et al. 2020

Toxics

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The human gut microbiome can be easily disturbed upon exposure to a range of toxic environmental agents. Environmentally induced perturbation in the gut microbiome is strongly associated with human disease risk. Functional gut microbiome alterations that may adversely influence human health is an increasingly appreciated mechanism by which environmental chemicals exert their toxic effects. In this review, we define the functional damage driven by environmental exposure in the gut microbiome as gut microbiome toxicity. The establishment of gut microbiome toxicity links the toxic effects of various environmental agents and microbiota-associated diseases, calling for more comprehensive toxicity evaluation with extended consideration of gut microbiome toxicity.

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The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice

Cited by 43 publications

References 111 publications

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Toxicity and Genotoxicity of Imidacloprid in Tadpoles of Leptodactylus Latrans and Physalaemus Cuvieri (Anura: Leptodactylidae)

Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases

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