The carcinogenic effect of aromatic amines: An epidemiological study on the role of o-toluidine and 4,4′-methylene bis (2-methylaniline) in inducing bladder cancer in man

Rubino, Giovanni; Scansetti, G; Piolatto, G; Pira, Enrico

doi:10.1016/0013-9351(82)90079-2

Cited by 92 publications

(37 citation statements)

References 8 publications

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“…Bladder cancer is related to cigarette smoking, (Surgeon General, 1982), and the cohort under study showed an elevated risk (compared to national mortality rates) of several smoking related cancers: lung (observed/expected ratio= 1.8), larynx (O/E=3.6), and oesophagus (O/E=4.1) (Rubino et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

“…Mortality of the whole cohort of workers employed in this factory between 1922 and 1970 (n=906) was followed up thereafter. A descriptive epidemiological paper has been previously published, showing an approximately 30-fold increased mortality for bladder cancer (based on 36 deaths) and a 50% elevated death rate for all causes (Rubino et al, 1982). Furthermore, those data showed a markedly increased risk (more than 60-fold, based on 5 deaths) in workers involved in production of fuchsin and safranine T.…”

mentioning

confidence: 97%

See 1 more Smart Citation

Bladder cancer mortality of workers exposed to aromatic amines: Analysis of models of carcinogenesis

Decarli¹,

Peto²,

Piolatto³

et al. 1985

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

Bladder cancer mortality of workers exposed to aromatic amines: Analysis of models of carcinogenesis

Decarli¹,

Peto²,

Piolatto³

et al. 1985

Br J Cancer

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“…None of these agents are known to be bladder carcinogens. Many epidemiologic studies have indicated that workers exposed to benzidene have a higher risk of bladder cancer, but benzidene was rarely if ever used at Rocky Flats (Case et al, 1954, Decarli et al, 1985, Rubino et al, 1982, Boyko et al, 1985, Morrison et al, 1985 The resin curing agent 4, 4'-methylene-dianiline has also been associated with development of the bladder cancer (Schulte et al, 1987), but occupational exposure to this chemical at Rocky Flats was also not likely.…”

Section: Tede (Rem) Participants In Tede Categorymentioning

confidence: 99%

FINAL REPORT FORMER RADIATION WORKER MEDICAL SURVEILLANCE PROGRAM AT ROCKY FLATS For Department of Energy Programs

Aldrich¹

2004

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“…A niline and its derivatives are very important for the synthesis of chemical products such as dyes, resins, and medicines, but these compounds have toxic, mutagenic, and carcinogenic properties (1)(2)(3)(4). Because anilines are widely used in industry and agriculture, they have frequently been detected in aquatic environments, and even in a drinking water treatment plant (5)(6)(7).…”

mentioning

confidence: 99%

Function of a Glutamine Synthetase-Like Protein in Bacterial Aniline Oxidation via γ-Glutamylanilide

et al. 2013

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Acinetobacter sp. strain YAA has five genes (atdA1 to atdA5) involved in aniline oxidation as a part of the aniline degradation gene cluster. From sequence analysis, the five genes were expected to encode a glutamine synthetase (GS)-like protein (AtdA1), a glutamine amidotransferase-like protein (AtdA2), and an aromatic compound dioxygenase (AtdA3, AtdA4, and AtdA5) (M. Takeo, T. Fujii, and Y. Maeda, J. Ferment. Bioeng. 85:17-24, 1998). A recombinant Pseudomonas strain harboring these five genes quantitatively converted aniline into catechol, demonstrating that catechol is the major oxidation product from aniline. To elucidate the function of the GS-like protein AtdA1 in aniline oxidation, we purified it from recombinant Escherichia coli harboring atdA1. The purified AtdA1 protein produced gamma-glutamylanilide (␥-GA) quantitatively from aniline and L-glutamate in the presence of ATP and MgCl 2 . This reaction was identical to glutamine synthesis by GS, except for the use of aniline instead of ammonia as the substrate. Recombinant Pseudomonas strains harboring the dioxygenase genes (atdA3 to atdA5) were unable to degrade aniline but converted ␥-GA into catechol, indicating that ␥-GA is an intermediate to catechol and a direct substrate for the dioxygenase. Unexpectedly, a recombinant Pseudomonas strain harboring only atdA2 hydrolyzed ␥-GA into aniline, reversing the ␥-GA formation by AtdA1. Deletion of atdA2 from atdA1 to atdA5 caused ␥-GA accumulation from aniline in recombinant Pseudomonas cells and inhibited the growth of a recombinant Acinetobacter strain on aniline, suggesting that AtdA2 prevents ␥-GA accumulation that is harmful to the host cell.

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The carcinogenic effect of aromatic amines: An epidemiological study on the role of o-toluidine and 4,4′-methylene bis (2-methylaniline) in inducing bladder cancer in man

Cited by 92 publications

References 8 publications

Bladder cancer mortality of workers exposed to aromatic amines: Analysis of models of carcinogenesis

Bladder cancer mortality of workers exposed to aromatic amines: Analysis of models of carcinogenesis

FINAL REPORT FORMER RADIATION WORKER MEDICAL SURVEILLANCE PROGRAM AT ROCKY FLATS For Department of Energy Programs

Function of a Glutamine Synthetase-Like Protein in Bacterial Aniline Oxidation via γ-Glutamylanilide

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