The Cardio- and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage

Abstract

Heart diseases, especially acute coronary syndrome (ACS), are among the most severe illnesses that often lead to death. Despite significant advances in the prevention and treatment of ACS, the incidence of the disease and its complications are very serious. The imbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation in the blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioral responses. So, the search for antioxidants with cardio- and neuroprotective effects is an urgent task. This study was aimed at evaluating the effects of Corvitin and 2-oxoglutarate on physiological parameters, heart histology, and markers of carbonyl/oxidative stress of rats with pituitrin-isoproterenol-induced myocardial damage (PIMD). Increased sweating, tachycardia, significantly decreased locomotor and exploratory activity, changes of ECG, heart histology, and biochemical changes were observed in the PIMD-group. The administration of Corvitin or 2-OG led to the recovery of locomotor and cognitive activities of the rats, improvement in heart histology, a decrease in the levels of thiobarbituric acid reactive substances, advanced glycated end products, and various changes in the activity of the antioxidant enzymes, 6 days after PIMD. So, Corvitin and exogenous 2-OG show cardio- and neuroprotective effects through the decrease of carbonyl/oxidative stress and regulation of the activity of the antioxidant system.

Cardioprotective effect of hemin in isoprenaline‐induced myocardial infarction: role of ATP‐sensitive potassium channel and endothelial nitric oxide synthase

“…ISO‐induced oxidative stress was assessed in our study that showed a marked increase in MDA, but a depletion of cardiac tissue GSH and serum TAC levels indicating the occurrence of severe lipid peroxidation and oxidative stress. These results are in line with Tkachenko et al , Wang et al , and Shahzada et al .…”

“…The pathogenesis of MI is not clearly defined, but its evaluation using ISO‐induced cardiac damage demonstrated the involvement of oxidative stress, inflammation, and apoptotic pathways. Currently, ISO‐induced myocardial ischemic injury in animal models is widely used to evaluate the effects of different cardioprotective agents . For the first time, our work evaluated the possible protective effect of HEM on ISO‐induced MI and the potential roles of HO1, eNOS, and K ATP in such injury; this model is considered as a preclinical evaluation step.…”

“…Cardiovascular diseases including myocardial infarction (MI) are among the most severe illnesses that could lead to death. MI occurs due to the imbalance between oxygen supply and oxygen demand followed by myocardial hypoxia . This imbalance with the excessive release of reactive oxygen species (ROS) is a major contributing factor in the development of MI.…”

Impact of corvitin and alpha-ketoglutarate on heart morphology, expression and activity of matrix metalloproteinases 2/9 in the heart of rats with doxorubicin-induced cardiomyopathy

“…However, additional clinical studies are necessary to develop alternative pharmacological approaches and clinical practices for the diversified patient population treated with anthracycline based chemotherapy. Taking into consideration the fact that oxidative stress and proteolysis play a significant role in development of doxorubicin cardiomyopathy, we have investigated the cardioprotective properties of corvitin and alpha-ketoglutarate, which exhibit a powerful antioxidant effect (Tkachenko et al, 2018). As follows from the presented results, both drugs have an insufficient regenerative effect on the morphological parameters of the heart -heart mass index and heart shape index (Fig.…”

Hepato- and hemato-protective properties of α-ketoglutarate under the combined effect of water-immobilization and emotional stress

“…Computerization of workplaces, which has led to the inactive condition of employees during the working day and an increase in the time spent by both children and adults sitting at the computer is a stressful load that worsens health (Warille et al, 2017). The chronic stage of stress conditions leads to a decrease in blood circulation due to vasoconstriction and an increase in the risk of developing hypoxic conditions in many organs and the nervous system (Ushakova et al, 2010;Tkachenko et al, 2018). Under such conditions, a large number of anaerobic metabolites find their way into the bloodstream, which leads to the development of oxidative stress (Lushchak, 2015;Sahafi, 2018, Wu, 2018.…”