The cell cycle

Hunt, Tim; Nasmyth, Kim; Novák, Béla

doi:10.1098/rstb.2011.0274

Cited by 55 publications

(34 citation statements)

References 18 publications

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“…Coordination between centrosome duplication and other events of the cell cycle is achieved in part through the activity of cyclins and cyclin-dependent kinases (CDKs; [31, 32]). Cyclins are a family of proteins whose levels rise and fall during the cell cycle [32, 33], and when their intracellular levels are sufficiently high, they bind to and activate cyclin-dependent kinases (CDKs).…”

Section: Control Of Centrosome Number In Cellsmentioning

confidence: 99%

“…Cyclins are a family of proteins whose levels rise and fall during the cell cycle [32, 33], and when their intracellular levels are sufficiently high, they bind to and activate cyclin-dependent kinases (CDKs). At the G1/S transition for example, both mother and daughter centrioles serve as a template for procentriole formation [34], and this event is tightly controlled by levels of cyclin E/CDK2 [35], the same cyclin-CDK pair responsible for establishing the pre-initiation complexes required for DNA replication [36].…”

Section: Control Of Centrosome Number In Cellsmentioning

confidence: 99%

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Centrosomal clustering contributes to chromosomal instability and cancer

Milunović-Jevtić

Mooney

Sulerud

et al. 2016

Current Opinion in Biotechnology

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Cells assemble mitotic spindles during each round of division to insure accurate segregation of their duplicated genome. In animal cells, stereotypical spindles have two poles, each containing one centrosome, from which microtubules are nucleated. In contrast, many cancer cells often contain more than two centrosomes and form transient multipolar spindle structures with more than two poles. In order to divide and produce viable progeny, the multipolar spindle intermediate must be reshaped into a pseudo-bipolar structure via a process called centrosomal clustering. Pseudo-bipolar spindles appear to function normally during mitosis, but they occasionally give rise to aneuploid and transformed daughter cells. Agents that inhibit centrosomal clustering might therefore work as a potential cancer therapy, specifically targeting mitosis in supernumerary centrosome-containing cells.

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Section: Control Of Centrosome Number In Cellsmentioning

confidence: 99%

Section: Control Of Centrosome Number In Cellsmentioning

confidence: 99%

Centrosomal clustering contributes to chromosomal instability and cancer

Milunović-Jevtić

Mooney

Sulerud

et al. 2016

Current Opinion in Biotechnology

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“…At a fundamental level, abnormal cellular division and migration represents the hallmark of cancer. Cyclin‐dependent kinases (CDKs), including CDK1, CDK2, CDK4, and CDK6, are key regulatory enzymes that control cell cycle transitions and the commitment to cell division . Cyclin‐dependent kinase 4 and CDK6 regulate the transition from the G1 to S phase, CDK2 regulates transition through the S phase, and CDK1 regulates the transition from the G2 to the M phase .…”

Section: Introductionmentioning

confidence: 99%

Clinical Management of Potential Toxicities and Drug Interactions Related to Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: Practical Considerations and Recommendations

et al. 2017

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“…Positive cell cycle regulatory proteins include cyclin D1, cyclin E, cyclin A, and their kinase partners, cyclin-dependent protein kinases (Cdk). Of these, cyclin D1-Cdk4/6 and cyclin E-Cdk2 are the key positive regulatory proteins in the progression of G1/S transition phase, and cyclin A-Cdk2 plays an important role in the G2/M transition phase (12).…”

Section: Introductionmentioning

confidence: 99%

Recombinant growth factor mixtures induce cell cycle progression and the upregulation of type I collagen in human skin fibroblasts, resulting in the acceleration of wound healing processess

Lee¹,

Choi

Cho

et al. 2014

International Journal of Molecular Medicine

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Abstract. Application of growth factor mixtures has been used for wound healing and anti-wrinkles agents. The aim of this study was to evaluate the effect of recombinant growth factor mixtures (RGFM) on the expression of cell cycle regulatory proteins, type I collagen, and wound healing processes of acute animal wound models. The results showed that RGFM induced increased rates of cell proliferation and cell migration of human skin fibroblasts (HSF). In addition, expression of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk)4, and Cdk2 proteins was markedly increased with a growth factor mixtures treatment in fibroblasts. Expression of type I collagen was also increased in growth factor mixturestreated HSF. Moreover, growth factor mixtures-induced the upregulation of type I collagen was associated with the activation of Smad2/3. In the animal model, RGFM-treated mice showed accelerated wound closure, with the closure rate increasing as early as on day 7, as well as re-epithelization and reduced inflammatory cell infiltration than phosphatebuffered saline (PBS)-treated mice. In conclusion, the results indicated that RGFM has the potential to accelerate wound healing through the upregulation of type I collagen, which is partly mediated by activation of Smad2/3-dependent signaling pathway as well as cell cycle progression in HSF. The topical application of growth factor mixtures to acute and chronic skin wound may accelerate the epithelization process through these molecular mechanisms.

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The cell cycle

Cited by 55 publications

References 18 publications

Centrosomal clustering contributes to chromosomal instability and cancer

Centrosomal clustering contributes to chromosomal instability and cancer

Clinical Management of Potential Toxicities and Drug Interactions Related to Cyclin-Dependent Kinase 4/6 Inhibitors in Breast Cancer: Practical Considerations and Recommendations

Recombinant growth factor mixtures induce cell cycle progression and the upregulation of type I collagen in human skin fibroblasts, resulting in the acceleration of wound healing processess

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