We present a detailed investigation of the radial distribution of blue straggler star (BSS) and binary populations in the Galactic globular cluster NGC 5466, over the entire extension of the system. We used a combination of data acquired with the Advanced Camera for Survey on board the Hubble Space Telescope, the LBC-blue mounted on the Large Binocular Telescope, and MEGACAM on the Canada-France-Hawaii Telescope. BSSs show a bimodal distribution with a mild central peak and a quite internal minimum. This feature is interpreted in terms of a relatively young dynamical age in the framework of the "dynamical clock" concept proposed by Ferraro et al. The estimated fraction of binaries is ∼6%-7% in the central region (r < 90 ) and slightly lower (∼5.5%) in the outskirts, at r > 200 . Quite interestingly, the comparison with the results of Milone et al. suggests that binary systems may also display a bimodal radial distribution, with the position of the minimum consistent with that of BSSs. If confirmed, this feature would give additional support to the scenario where the radial distribution of objects more massive than the average cluster stars is primarily shaped by the effect of dynamical friction. Moreover, this would also be consistent with the idea that the unperturbed evolution of primordial binaries could be the dominant BSS formation process in low-density environments.