The Central Mechanisms of Resistance Training and Its Effects on Cognitive Function

Chow, Zi-Siong; Moreland, Ashleigh; Macpherson, Helen; Teo, Wei‐Peng

doi:10.1007/s40279-021-01535-5

Cited by 41 publications

(28 citation statements)

References 116 publications

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“…Indeed, low-intensity walking increased: gray matter volume in cortical and sub-cortical brain areas; microstructural integrity in several white matter tracts; cortical and hippocampal gray matter volume, and reduced white matter lesions in a correlated manner with improvements in aerobic fitness (Best et al, 2015;Burzynska et al, 2017;Chen et al, 2020;Mendez Colmenares et al, 2021;Oberlin et al, 2016). Low-intensity RT and cognitive training were also efficacious to improve cognitive function and markers of NP (Chow et al, 2021;Intzandt et al, 2021). In fact, there is meta-analytical evidence suggesting that exercise, including RT, even below World Health Organization guidelines could provide health and mortality benefits (Bull et al, 2020;Dempsey et al, 2022;Fyfe et al, 2022;Gallardo-Gomez et al, 2022).…”

Section: Introductionmentioning

confidence: 90%

“…This has previously been reported in the literature. Such analyses would have biased effect size estimates, as we would have failed to include potentially hundreds of studies summarized by targeted reviews on the effects of exercise on cognitive and motor outcomes (Chow et al, 2021;Dascal et al, 2019;Falck et al, 2019;Gallardo-Gomez et al, 2022;Landrigan et al, 2020;Li et al, 2018;Lopez et al, 2018;McSween et al, 2019;Quigley et al, 2020;Sanders et al, 2019;Song and Yu, 2019;Yeh et al, 2021).…”

Section: Statistical Analysesmentioning

confidence: 99%

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The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

Hortobágyi

Vetrovsky

Balbim

et al. 2022

Ageing Research Reviews

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Section: Introductionmentioning

confidence: 90%

Section: Statistical Analysesmentioning

confidence: 99%

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

Hortobágyi

Vetrovsky

Balbim

et al. 2022

Ageing Research Reviews

View full text Add to dashboard Cite

“…Compared with drugs and surgery, exercise intervention is more easily accepted by most patients. Second, exercise is a good lifestyle with broad benefits to physical and mental health ( Paluska and Schwenk, 2000 ) and many disorders including age- or disease-related cognitive declines ( Prakash et al, 2015 ; Chow et al, 2021 ), sarcopenia ( Steffl et al, 2017 ), type 2 diabetes ( Aune et al, 2015 ), rheumatoid arthritis ( Katz et al, 2020 ), etc. The advantages of exercise intervention and the exciting omics findings on neurodegenerative diseases motivated us to review the omics studies on exercise and neurodegenerative diseases and to summarize the related features and potential mechanisms on disease management.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases

Guo

Wang²,

Chao³

et al. 2022

Front. Aging Neurosci.

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IntroductionNeurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, are heavy burdens to global health and economic development worldwide. Mounting evidence suggests that exercise, a type of non-invasive intervention, has a positive impact on the life quality of elderly with neurodegenerative diseases. X-omics are powerful tools for mapping global biochemical changes in disease and treatment.MethodThree major databases were searched related to current studies in exercise intervention on neurodegenerative diseases using omics tools, including metabolomics, metagenomics, genomics, transcriptomics, and proteomics.ResultWe summarized the omics features and potential mechanisms associated with exercise and neurodegenerative diseases in the current studies. Three main mechanisms by which exercise affects neurodegenerative diseases were summed up, including adult neurogenesis, brain-derived neurotrophic factor (BDNF) signaling, and short-chain fatty acids (SCFAs) metabolism.ConclusionOverall, there is compelling evidence that exercise intervention is a feasible way of preventing the onset and alleviating the severity of neurodegenerative diseases. These studies highlight the importance of exercise as a complementary approach to the treatment and intervention of neurodegenerative diseases in addition to traditional treatments. More mechanisms on exercise interventions for neurodegenerative diseases, the specification of exercise prescriptions, and differentiated exercise programs should be explored so that they can actually be applied to the clinic.

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“…Many clinical studies and meta-analyses have shown that exercise promotes the recovery of motor and non-motor symptoms in patients with PD ( da Silva et al, 2018 ). For example, implementing an exercise program improves the gait, balance, and motor capacity of patients with PD and their quality of life ( Gilat et al, 2021 ), and resistance exercises can promote neuroplastic changes within the central nervous system of patients with PD to improve cognitive functioning ( Chow et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Exercise on Parkinson’s Disease: A Meta-Analysis of Brain Imaging Studies

Guo

Sun

et al. 2022

Front. Hum. Neurosci.

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BackgroundExercise is increasingly recognized as a key component of Parkinson’s disease (PD) treatment strategies, but the underlying mechanism of how exercise affects PD is not yet fully understood.ObjectiveThe activation likelihood estimation (ALE) method is used to study the mechanism of exercise affecting PD, providing a theoretical basis for studying exercise and PD, and promoting the health of patients with PD.MethodsRelevant keywords were searched on the PubMed, Cochrane Library, and Web of Science databases. Seven articles were finally included according to the screening criteria, with a total sample size of 97 individuals. Using the GingerALE 3.0.2 software, an ALE meta-analysis was performed using seven studies that met the requirements, and the probability of the cross-experiment activation of each voxel was calculated.ResultsThe meta-analysis produced seven clusters, and major activations were found in the cerebellum, occipital lobe, parietal lobe, and frontal lobe brain regions.ConclusionExercise for PD mainly results in the enhanced activation of the cerebellum, occipital lobe, parietal lobe, and frontal lobe. Exercise for PD does not cause a change in the activation of a single brain area, and the observed improvement may result from coordinated changes in multiple brain areas.

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The Central Mechanisms of Resistance Training and Its Effects on Cognitive Function

Cited by 41 publications

References 116 publications

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases

Effects of Exercise on Parkinson’s Disease: A Meta-Analysis of Brain Imaging Studies

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