The circadian syndrome predicts cardiovascular disease better than metabolic syndrome in Chinese adults

Shi, Zumin; Tuomilehto, Jaakko; Kronfeld‐Schor, Noga; Alberti, George; Stern, Naftali; El‐Osta, Assam; Bilu, Carmel; Einat, Haim; Zimmet, Paul

doi:10.1111/joim.13204

Cited by 45 publications

(48 citation statements)

References 31 publications

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“…The concept of CircS was first proposed by Zimmet et al in 2019 based on the concept of MetS and then defined with a cutoff value by Shi et al (12,15). In the definition of CircS, another two risk factors, which were depression and reduced sleep duration, were clustered with the components of MetS including abdominal obesity, hypertension, hyperglycemia, high triglycerides, and low high-density lipoprotein (HDL) cholesterol.…”

Section: Measurements Of Variables: Circs and Luts/bphmentioning

confidence: 99%

“…The specific cutoff values of the seven components in CircS and MetS were presented in Supplementary Table 1. According to one previous study, the cutoff for MetS was set as ≥3 components, while for CircS, the cutoff was ≥4 components (15).…”

Section: Measurements Of Variables: Circs and Luts/bphmentioning

confidence: 99%

“…In this study, the following covariates were summarized: age, marital status [married/cohabitated, others (divorced, widowed, never married, and separated)], education, smoking (current smoker, non-smoker, and exsmoker), alcohol consumption (drinker or non-drinker), uric acid, anemia (<120 g/l), stroke (yes or no), and chronic kidney disease (CKD, yes or no). The estimated glomerular filtration rate (eGFR) was calculated to evaluate the kidney function using CKD-EPI creatinine equation according to one previous study (15). The cutoff for diagnosing CKD was set as <60 ml min −1 /1.73 m 2 (15).…”

Section: Covariatesmentioning

confidence: 99%

“…The estimated glomerular filtration rate (eGFR) was calculated to evaluate the kidney function using CKD-EPI creatinine equation according to one previous study (15). The cutoff for diagnosing CKD was set as <60 ml min −1 /1.73 m 2 (15).…”

Section: Covariatesmentioning

confidence: 99%

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The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

Xiong

Wang

et al. 2021

Front. Med.

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Background: The prevalence of lower urinary tract symptoms (LUTS) suggestive of benign prostate hyperplasia (BPH) increases in men. Although several risk factors, including metabolic syndrome (MetS) and depression, were identified, the underlying etiological factor remains unclear. Recently, circadian syndrome (CircS) was proposed as a novel risk cluster based on MetS. To compare the predictive power of the CircS and MetS for LUTS/BPH, this study was performed.Materials and Methods: In the baseline survey, 4,390 men older than 40 years from the China Health and Retirement Longitudinal Study were enrolled. Of them, 3,658 men were followed in the 2015 survey. Logistic regression was adopted to examine the relationships between CircS, MetS, and LUTS/BPH. To further verify the association, propensity score matching was used for sensitivity analyses. Moreover, the participants who had LUTS/BPH at the baseline were excluded to test the longitudinal relationships between CircS, MetS, and LUTS/BPH. In addition, we employed the receiver operating characteristic (ROC) curve analysis to compare the predictive power using the number of components of CircS and MetS. The DeLong test was used to test the disparities of area under the curves (AUCs).Results: The prevalence of CircS and MetS in aging men was 30.23 and 38.36%, respectively. The odds ratios for prevalent LUTS/BPH were 1.61 (95% CI = 1.29–2.00, P < 0.001) and 1.34 (95% CI = 1.08–1.66, P < 0.01), respectively, in aging men. This increased risk was also observed in incident LUTS/BPH. The prevalence of LUTS/BPH in normal, CircS alone, MetS alone, and both CircS and MetS groups was 6.96, 8.77, 7.83, and 10.77%, respectively. The AUCs for CircS predicting prevalent and incident LUTS/BPH were higher than those for MetS (0.582 vs. 0.556 for incident LUTS/BPH, P < 0.001; 0.574 vs. 0.561 for prevalent LUTS/BPH, P < 0.05).Conclusions: The CircS predicts both incident and prevalent LUTS/BPH better than MetS.

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Section: Measurements Of Variables: Circs and Luts/bphmentioning

confidence: 99%

Section: Measurements Of Variables: Circs and Luts/bphmentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

See 2 more Smart Citations

The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

Xiong

Wang

et al. 2021

Front. Med.

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“…Circadian dysfunction has been proposed and defined as the presence of any four of the following seven traits, including elevated waist circumference, elevated triglycerides, reduced high-density lipoprotein (HDL)-cholesterol, elevated blood pressure, elevated fasting glucose, short sleep duration (<6 h/day), and the depression symptom ( 7 ). Shi et al ( 11 ) assessed the association between circadian syndrome and cardiovascular disease (CVD), and the result also suggested that the circadian syndrome was a strong predictor for CVD occurrence. However, to the best of our knowledge, there has been no study that examined the association between circadian syndrome and stroke so far.…”

Section: Introductionmentioning

confidence: 99%

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

et al. 2022

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AimThe aim of this study was to assess the relationship of circadian syndrome and stroke.MethodsWe performed a cross-sectional analysis of 11,855 participants from the National Health and Nutrition Examination Survey (NHANES) database between 2005 and 2018, and collected the baseline characteristics. Multivariate logistic regression models were developed to explore the association between circadian syndrome and stroke. Simultaneously, subgroup analyses based on the difference of gender, race, and components associated with circadian syndrome also were performed. The odds ratio (OR) and 95% CI were calculated in this study.ResultsAll the participants were divided into the non-stroke group and the stroke group. There were approximately 3.48% patients exclusively with stroke and 19.03% patients exclusively with circadian syndrome in our study. The results suggested that the risk of stroke in patients with circadian syndrome was higher than that in patients without circadian syndrome (OR = 1.322, 95 CI%: 1.020–1.713). Similar associations were found in women with circadian syndrome (OR = 1.515, 95 CI%: 1.086–2.114), non-Hispanic whites with circadian syndrome (OR = 1.544, 95 CI%: 1.124–2.122), participants with circadian syndrome who had elevated waist circumference (OR = 1.395, 95 CI%: 1.070–1.819) or short sleep (OR = 1.763, 95 CI%: 1.033–3.009).ConclusionCircadian syndrome was associated with the risk of stroke. Particularly, we should pay more close attention to the risk of stroke in those populations who were female, non-Hispanic whites, had the symptoms of elevated waist circumference or short sleep.

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The circadian syndrome is a predictor for cognition impairment in middle‐aged adults: Comparison with the metabolic syndrome

Shi,

Stern,

Liu

et al. 2024

Diabetes Metabolism Res

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AimsCircadian syndrome (CircS) is considered a better predictor for cardiovascular disease than the metabolic syndrome (MetS). We aim to examine the associations between CircS and MetS with cognition in Chinese adults.MethodWe used the data of 8546 Chinese adults aged ≥40 years from the 2011 China Health and Retirement Longitudinal Study. MetS was defined using harmonised criteria. CircS included the components of MetS plus short sleep and depression. The cut‐off for CircS was set as ≥4. Global cognitive function was assessed during the face‐to‐face interview.ResultsCircS and MetS had opposite associations with the global cognition score and self‐reported poor memory. Compared with individuals without the CircS and MetS, the regression coefficients (95%CI) for global cognition score were −1.02 (−1.71 to −0.34) for CircS alone and 0.52 (0.09 to 0.96) for MetS alone in men; −1.36 (−2.00 to −0.72) for CircS alone and 0.60 (0.15 to 1.06) for MetS alone in women. Having CircS alone was 2.53 times more likely to report poor memory in men (95%CI 1.80–3.55) and 2.08 times more likely in women (95%CI 1.54–2.81). In contrast, having MetS alone was less likely to report poor memory (OR 0.64 (0.49–0.84) in men and 0.65 (0.52–0.81) in women). People with CircS and MetS combined were more likely to have self‐reported poor memory.ConclusionsCircS is a strong and better predictor for cognition impairment than MetS in Chinese middle‐aged adults. MetS without short sleep and depression is associated with better cognition.

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The circadian syndrome predicts cardiovascular disease better than metabolic syndrome in Chinese adults

Cited by 45 publications

References 31 publications

The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging Males: A 4-Year Follow-Up Study

Relationship between circadian syndrome and stroke: A cross-sectional study of the national health and nutrition examination survey

The circadian syndrome is a predictor for cognition impairment in middle‐aged adults: Comparison with the metabolic syndrome

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