Brains perform with remarkable efficiency, are capable of prodigious computation, and are marvels of communication. We are beginning to understand some of the geometric, biophysical, and energy constraints that have governed the evolution of cortical networks. To operate efficiently within these constraints, nature has optimized the structure and function of cortical networks with design principles similar to those used in electronic networks. The brain also exploits the adaptability of biological systems to reconfigure in response to changing needs.Neuronal networks have been extensively studied as computational systems, but they also serve as communications networks in transferring large amounts of information between brain areas. Recent work suggests that their structure and function are governed by basic principles of resource allocation and constraint minimization, and that some of these principles are shared with human-made electronic devices and communications networks. The discovery that neuronal networks follow simple design rules resembling those found in other networks is striking because nervous systems have many unique properties.To generate complicated patterns of behavior, nervous systems have evolved prodigious abilities to process information. Evolution has made use of the rich molecular repertoire, versatility, and adaptability of cells. Neurons can receive and deliver signals at up to 10 5 synapses and can combine and process synaptic inputs, both linearly and nonlinearly, to implement a rich repertoire of operations that process information (1). Neurons can also establish and change their connections and vary their signaling properties according to a variety of rules. Because many of these changes are driven by spatial and temporal patterns of neural signals, neuronal networks can adapt to circumstances, self-assemble, autocalibrate, and store information by changing their properties according to experience.The simple design rules improve efficiency by reducing (and in some cases minimizing) the resources required to implement a given task. It should come as no surprise that brains have evolved to operate efficiently. Economy and efficiency are guiding principles in physiology that explain, for example, the way in which the lungs, the circulation, and the mitochondria are matched and co-regulated to supply energy to muscles (2). To identify and explain efficient design, it is necessary to derive and apply the structural and physicochemical relationships that connect resource use to performance. We consider first a number of studies of the geometrical constraints on packing and wiring that show that the brain is organized to reduce wiring costs. We then examine a constraint that impinges on all aspects of neural function but has only recently become apparent-energy consumption. Next we look at energy-efficient neural codes that reduce signal traffic by exploiting the relationships that govern the representational