The clinical implications of platelet-rich fibrin on periodontal regeneration: A systematic review

Madi, Marwa; Elakel, Ahmed

doi:10.1016/j.sdentj.2020.12.002

Cited by 11 publications

(9 citation statements)

References 34 publications

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“…The positive outcomes indicate that participants receiving platelet-rich fibrin may have benefited from adherence to oral hygiene instructions [55]. Different probing depths could potentially affect the outcomes when using platelet-rich fibrin in conjunction with graft material [56]. Moreover, due to individual differences in the activity of fibrin-rich platelets obtained from participants, standardization may be difficult.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Utilizing Platelet-Rich Fibrin for Managing Periodontal Intrabony Defects in Conjunction with Graft Material: A Systematic Review and Meta-Analysis

Park,

Han,

Kim

et al. 2024

Applied Sciences

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Platelet-rich fibrin has become increasingly popular in recent years due to its remarkable capacity to accelerate the post-surgery wound healing process, reduce inflammation, and promote tissue repair. This study aimed to perform a meta-analysis to evaluate the effect of platelet-rich fibrin in mixture form with bone substitute, as a membrane, or in combination. A comprehensive search using a combination of controlled vocabulary (MeSH) and free-text terms was undertaken by two reviewers to identify published randomized clinical trials. Three major electronic databases (Medline via PubMed, Cochrane database, and Embase) and the clinical trials registry (clinicaltrials.gov) were searched up to 9 July 2023. The results of the meta-analysis showed that the pooled standardized mean difference of probing depth for platelet-rich fibrin was 0.61 (95% CI, 0.33 to 0.88). The results of the meta-analysis showed that the mean difference in clinical attachment level for platelet-rich fibrin was 0.68 (95% CI, 0.35 to 1.01). The results of the meta-analysis showed that the mean difference in bone fill for platelet-rich fibrin was 0.50 (95% CI, 0.23 to 0.78). In conclusion, the study found that platelet-rich fibrin was effective as adjunct to periodontal regeneration.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Utilizing Platelet-Rich Fibrin for Managing Periodontal Intrabony Defects in Conjunction with Graft Material: A Systematic Review and Meta-Analysis

Park,

Han,

Kim

et al. 2024

Applied Sciences

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“…B) Although the inflammatory state in the oral cavity may be related to a brain degeneration syndrome such as dementia and AD, more studies are still needed to investigate the role of periodontal bacteria and PG (multimicrobial hypothesis) in the pathogenesis and worsening of AD. Thus, it is suggested that greater care be taken with oral hygiene in individuals suffering from AD and dementia [9,13,14,23,24,33,34,36,40,50,54,55,59,62,64,67,74]. C) Periodontal disease represents a factor in the progression (exacerbation) of Alzheimer's disease via induced pathogenic bacteria, since these individuals may have poor oral hygiene care, either due to forgetfulness or poor manual dexterity.…”

Section: Discussionmentioning

confidence: 99%

From Oral Hygiene to Cognitive Health: Examining the Relationship between Periodontal Disease and Alzheimer's

Viana,

Rodrigues Holanda,

Araújo

et al. 2024

Arch. Curr. Res. Int.

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Aim: The aim of this study was to review the literature in an integrative way, looking for scientific evidence to see if there is a relationship between periodontal disease (PD) and Alzheimer's disease (AD). Study Design: Review the literature in an integrative. Methodology: The search was carried out on the VHL Regional Portal with articles published in English, Spanish and Portuguese. 169 articles were found between 2021 and 2023. Of this total, 106 were excluded, 5 for being duplicates and 101 for not meeting the inclusion criteria. Of the studies analyzed, most report evidence of an association between PD and AD, with Phorphyromonas gingivalis (PG) as the common pathogen in both conditions. Results: The results revealed four aspects: a) PG and other periodontopathogens (PP) play a role in the systemic inflammation process that accelerates the onset and progression of AD; b) even given the link between the oral-brain aetiological axis hypothesis of a brain degeneration syndrome such as AD, it is still necessary to further investigate the role of PP and PG (multimicrobial hypothesis) in the pathogenesis and worsening of AD; c) PD represents a factor in the progression of AD via induced pathogenic bacteria, since these individuals may have poor oral hygiene care, due to forgetfulness or less manual dexterity; d) Age and gender are important variables to consider when assessing the association between PD and AD. Conclusion: Thus, we can infer that despite the number of studies observed through this integrative review, there is still not enough research with a high level of scientific evidence on this association. Thus, new studies with greater methodological rigor in terms of the methods applied and the criteria for diagnosing the pathologies need to be carried out in order to obtain a better understanding of the relationship between PD and AD.

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“…In a clinical setting, PRF represents an autologous source of growth factors, such as PDGF, VEGF, IGF, TGF-B, gradually released over a 10-day period [ 45 ]. In the clinic, its use has been successful in promoting hard and soft tissue regeneration [ 8 , 46 ]. Likewise, in the treatment of controlled periodontal disease, the combination of PRF with autologous osseous tissue reduces the pocket probing depth.…”

Section: Discussionmentioning

confidence: 99%

Viability and Adhesion of Periodontal Ligament Fibroblasts on a Hydroxyapatite Scaffold Combined with Collagen, Polylactic Acid–Polyglycolic Acid Copolymer and Platelet-Rich Fibrin: A Preclinical Pilot Study

et al. 2022

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Background: Conventional periodontal therapy relies on bone regeneration strategies utilizing scaffolds made of diverse materials, among which collagen, to promote cell adhesion and growth. Objective: To evaluate periodontal ligament fibroblast (HPdLF) cell adhesion and viability for periodontal regeneration purposes on hydroxyapatite scaffolds containing collagen (HAp-egg shell) combined with polylactic acid–polyglycolic acid copolymer (PLGA) and Platelet-Rich Fibrin (PRF). Methods: Four variations of the HAp-egg shell were used to seed HPdLF for 24 h and evaluate cell viability through a live/dead assay: (1) (HAp-egg shell/PLGA), (2) (HAp-egg shell/PLGA + collagen), (3) (HAp-egg shell/PLGA + PRF) and (4) (HAp-egg shell/PLGA + PRF + collagen). Cell adhesion and viability were determined using confocal microscopy and quantified using central tendency and dispersion measurements; significant differences were determined using ANOVA (p < 0.05). Results: Group 1 presented low cell viability and adhesion (3.70–10.17%); groups 2 and 3 presented high cell viability and low cell adhesion (group 2, 59.2–11.1%, group 3, 58–4.6%); group 4 presented the highest cell viability (82.8%) and moderate cell adhesion (45%) (p = 0.474). Conclusions: The effect of collagen on the HAp-egg shell/PLGA scaffold combined with PRF favored HPdLF cell adhesion and viability and could clinically have a positive effect on bone defect resolution and the regeneration of periodontal ligament tissue.

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The clinical implications of platelet-rich fibrin on periodontal regeneration: A systematic review

Cited by 11 publications

References 34 publications

The Efficacy of Utilizing Platelet-Rich Fibrin for Managing Periodontal Intrabony Defects in Conjunction with Graft Material: A Systematic Review and Meta-Analysis

The Efficacy of Utilizing Platelet-Rich Fibrin for Managing Periodontal Intrabony Defects in Conjunction with Graft Material: A Systematic Review and Meta-Analysis

From Oral Hygiene to Cognitive Health: Examining the Relationship between Periodontal Disease and Alzheimer's

Viability and Adhesion of Periodontal Ligament Fibroblasts on a Hydroxyapatite Scaffold Combined with Collagen, Polylactic Acid–Polyglycolic Acid Copolymer and Platelet-Rich Fibrin: A Preclinical Pilot Study

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