The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study

Hentschel, Frank; Kreis, M.; Damian, Marinella; Krumm, Bertram; Frölich, Lutz

doi:10.1002/gps.1333

Cited by 37 publications

(22 citation statements)

References 25 publications

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“…Dentre os instrumentos que se revelaram úteis para os fins propostos destaca-se a bateria neuropsicológica Consortium to Estabilish a Registry for Alzheimer's Disease (CERAD), que envolve a avaliação de múltiplas funções cognitivas e permite detectar quadros demenciais em idosos (Bertolucci et al, 2001;Chandler et al, 2005;Collie et al, 2001;Hentschel, Kreis, Damian, Krumm, & Frölich, 2005;Maccioni et al, 2006;Spangenberg, Henderson, & Wagner, 1997;Unverzagt et al, 2001;Whyte et al, 2005;Xiang, Haroutunian, Ho, Purohit, & Pasinetti, 2006). Testada inicialmente por Morris et al (1989), essa bateria apresentou alto índice de concordância entre examinadores.…”

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Desempenho de idosos na bateria cognitiva CERAD: relações com variáveis sociodemográficas e saúde percebida

Ribeiro¹,

Oliveira²,

Cupertino³

et al. 2010

Psicol. Reflex. Crit.

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ResumoO objetivo do estudo foi avaliar o desempenho de idosos em testes cognitivos da bateria CERAD e sua relação com variáveis sociodemográficas e saúde percebida. Foram estudados 158 idosos integrantes do estudo PENSA (Processo do Envelhecimento Saudável). A média de idade foi de 70,2 anos (DP=8,2) e a média de escolaridade de 7 anos (DP=4). O melhor desempenho cognitivo, na maior parte dos testes, esteve associado a mais anos de escolaridade, menor idade e viver com companheiro. No teste de nomeação, observou-se melhor desempenho entre os homens, e melhor desempenho nos testes de memória esteve associado com melhor saúde percebida. Concluiu-se que escolaridade, idade, gênero, estado civil e saúde geral percebida implicaram diferenças significativas no desempenho cognitivo dos idosos. Palavras-chave: Idoso; Cognição; Neuropsicologia. Abstract CERAD cognitive battery and its relation with socio-demographic variables and perceived health. The sample was composed by 158 community-dwelling elderly people who participated in the PENSA study (Study of Healthy Aging Process). Ages varied from 60 to 99 years old (M=70.2; SD=8.2); with an average of seven years of education (SD=4). Higher cognitive performance was associated with higher education, lower age, and having a partner. In the naming test, men outperformed women whereas higher memory performance was associated with better perceived health among women. It was concluded that education, age, gender, marital status and perceived health may be associated to variability in cognitive performance among elderly people. Keywords: Elderly person; Cognition; Neuropsychology.No processo de envelhecimento normal, podem ser observadas alterações cognitivas que não chegam a comprometer a funcionalidade do indivíduo. Contudo, no envelhecimento patológico, tal como nas demências, as perdas neurológicas resultam em limitações na funcionalidade, as quais afetam os domínios social, ocupacional, de lazer e das atividades da vida diária do paciente (Abreu & Tamai, 2006). O declínio e a estabilidade de diferentes funções cognitivas, ao longo do processo de envelhecimento, são afetados por diferenças interindividuais, que envolvem aspectos sociodemográficos, genéticos, de estilo de vida e de saúde física.Estudos nacionais e internacionais mostraram que o aumento da idade e o baixo nível educacional estão relacionados ao pior funcionamento cognitivo em idosos

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Desempenho de idosos na bateria cognitiva CERAD: relações com variáveis sociodemográficas e saúde percebida

Ribeiro¹,

Oliveira²,

Cupertino³

et al. 2010

Psicol. Reflex. Crit.

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“…MRI is a complex field including different approaches which permit the investigation of several aspects of brain structure and function. The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementias is wellestablished (Hentschel et al, 2005), however, conventional MRI in association with advanced methods of image processing (e.g. voxel-based morphometry) represent a powerful tool in tissue structure analysis.…”

Section: Mri-based Analyses Techniques: Adding Useful Information To mentioning

confidence: 99%

Neuroimaging Findings in Dementia with Lewy Body: A Review

Baglio¹,

Preti²,

Farina³

2012

Neuroimaging - Methods

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“…The fact that the tentative diagnosis is based on statements of the vascular risk factors is being regarded as the reason for this. However, the risk need not be apparent in the imaging, so the diagnostic criteria for VD according to NINDS-AIREN [5] are not fulfilled [6].…”

Section: Introductionmentioning

confidence: 99%

The Molecular Genetics of the Risk Factors of Vascular Dementias*

Hentschel

Kölsch

2007

Clin Neuroradiol

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Secondary prevention of the age-associated dementias requires clarification of the risk factors. Vascular dementia is mainly due to cerebral hypoxic or hemorrhagic infarcts as a consequence of cerebrovascular disease. For this reason attention must be paid to the risk factors of cerebrovascular diseases. Both environmental and genetic causes determine the manifestation of these risk factors, for example, factors related to cholesterol and glucose metabolism, regulation of blood pressure and inflammatory cascades. Disturbances of genetically driven processes increase the risk of a cerebrovascular event. In this respect candidate genes and their polymorphisms need to be considered. In contrast to Alzheimer's disease, relevant molecular genetic investigations into vascular dementia are rare. For this reason research findings related to stroke and neurodegenerative dementias need to be extended and discussed with regard to their relevance in vascular dementia. Primary prevention of vascular dementia is not possible at present; secondary prevention, using both medicinal therapy and lifestyle modifications, can counteract susceptibility to the risks. ZusammenfassungBedeutsam für die Sekundärprävention der Altersdemenzen ist die Aufklärung der Risikofaktoren. Wichtigstes Risiko für die vaskuläre dementielle Entwicklung ist der zerebrale hypoxische oder hämorrhagische Infarkt. Daher richtet sich die Aufmerksamkeit auf die Risikofaktoren der zerebrovaskulären Erkrankungen. Diese Risikofaktoren sind u.a. im Zusammenhang mit dem Cholesterin-und dem Glukosemetabolismus, der Blutdruckregulation und der Entzündungskaskade genetisch determiniert. Die Störung der genetisch gesteuerten Prozessabläufe vergrößert das Risiko eines zerebrovaskulären Ereignisses. Dazu sind Kandidatengene und deren Polymorphismen zu diskutieren. Im Gegensatz zur Alzheimer-Demenz gibt es kaum molekulargenetische Untersuchungen zur vaskulären Demenz. Daher werden Analogieschlüsse von den neurodegenerativen auf die Entwicklung der vaskulären Demenzen vorgenommen. Eine Primärprävention ist zumindest derzeit nicht möglich; die Sekundärprävention richtet sich mit Medikamenten und Verhaltensempfehlungen gegen die Realisierung der Risiken.Schlüsselwörter: Vaskuläre Demenz · Hirninfarkt · Mikroangiopathie · Molekulargenetik · Risiko * This paper is based on results processed for and as part of a mutual project (DFG HE 2748 and DFG KO 2327).

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The clinical utility of structural neuroimaging with MRI for diagnosis and differential diagnosis of dementia: a memory clinic study

Abstract: MRI as well as neuropsychological testing improves early detection and differential diagnosis of dementia and additionally supplies clinically relevant findings. MRI carries added clinical value in the investigation of dementias.

Cited by 37 publications

References 25 publications

Desempenho de idosos na bateria cognitiva CERAD: relações com variáveis sociodemográficas e saúde percebida

Desempenho de idosos na bateria cognitiva CERAD: relações com variáveis sociodemográficas e saúde percebida

Neuroimaging Findings in Dementia with Lewy Body: A Review

The Molecular Genetics of the Risk Factors of Vascular Dementias*

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