The commercial development of planar optical biosensors

Robinson, G.A.

doi:10.1016/0925-4005(95)01660-0

Cited by 52 publications

(16 citation statements)

References 26 publications

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“…Optical waveguide modeling and design for evanescent field chemical [415] and biochemical [170] sensors have been discussed. Some of the commercially available structures have been outlined and the quality of planar waveguides in comparison with fibers has been considered [372]. Literature relating to the various principles is summarized in Table 1-4. In principle, the effective refractive index, n^ of the waveguide is measured to interrogate the refractive index of the "superstate" (the medium close to the waveguide in the area of the evanescent field) [304].…”

Section: Waveguidesmentioning

confidence: 99%

Opto-Chemical and Opto-Immuno Sensors

Gauglitz¹

1996

Sensors Update

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Section: Waveguidesmentioning

confidence: 99%

Opto-Chemical and Opto-Immuno Sensors

Gauglitz¹

1996

Sensors Update

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“…Accurate and highly sensitive 'biosensors' that incorporate a biological recognition element and a physical transduction element are being developed for the specific and fast detection of minute amounts of particular biomolecules (Robinson, 1995;Thompson and Stone, 1997). The recognition molecules provide the specificity and affinity for the analyte of interest.…”

Section: Introductionmentioning

confidence: 99%

Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays

Huang

Reekmans

Saerens

et al. 2005

Biosensors and Bioelectronics

208

113

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“…[1][2][3][4]. Especially integrated-optical (IO) sensors are more and more commercialized (e.g., Genalyte, Optisense, PLCD, Farfield Sensors) [5], mainly because of their high intrinsic sensitivity [6] in combination with the possibilities they offer for integration in optofluidic devices [7]. Many different types of IO sensors have been described in the literature such as grating coupler devices, silicon wires, photonic crystals, waveguide interferometers and microring resonators (MRRs) [6,8,9].…”

Section: Introductionmentioning

confidence: 99%

Performance of Arrayed Microring Resonator Sensors with the TriPleX Platform

GAJ¹,

RG²

2016

J Biosens Bioelectron

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Integrated-optical (bio) chemical sensors are more and more commercialized, mainly because of their high intrinsic sensitivity in combination with the possibilities they offer for integration in optofluidic devices. The microring resonator (MRR), for example, is a very feasible structure to be used as microarray sensor element for multiplex biosensing. Fabrication of MRRs has been described in the case of the TriPleX platform employing well-defined stacks of stoichiometric Si 3 N 4 and SiO 2 material. This platform allows for a wide variety of applications, due to its intrinsic low loss and its transparency for the VIS/NIR wavelength range. In the present paper, we describe the recent achievements in the characterization of arrays of these MRRs regarding temperature sensitivity, refractive index sensitivity and protein immobilization performance. Furthermore, the use of a reference channel/reference MRR is demonstrated in order to show the advantage of compensation of unintended change in temperature or sample composition. The refractive index sensitivity was determined to be 104 nm/RIU and the limit of detection was about 2 × 10 -6 RIU. MRRs appeared to behave very comparable (expressed as the coefficient of (intra-array) variation (CV)) regarding the response to temperature (CV≈0.3%) as well as refractive index (CV<0.1%). Furthermore, it is shown that protein immobilization onto the different MRRs of the same arrays can be realized in a comparable way (CV<3%). A good comparability (i.e., a low variation) in these aspects allows for the use of internal referencing in order to compensate for unintended change in temperature or refractive index and also helps to attain a high assay precision in the ultimate biosensing application. Ongoing research is focused on the integration of more functionality on chip and further miniaturization in order to allow for fabrication of complex, though affordable, sensor devices.

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The commercial development of planar optical biosensors

Cited by 52 publications

References 26 publications

Opto-Chemical and Opto-Immuno Sensors

Opto-Chemical and Opto-Immuno Sensors

Prostate-specific antigen immunosensing based on mixed self-assembled monolayers, camel antibodies and colloidal gold enhanced sandwich assays

Performance of Arrayed Microring Resonator Sensors with the TriPleX Platform

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