The comparison of STA-MCA bypass and BMT for symptomatic internal carotid artery occlusion disease: a systematic review and meta-analysis of long-term outcome

Cai, Shifei; Fan, Hao; Peng, Chao; Wu, Yuexiu; Yang, Xinyu

doi:10.1186/s41016-021-00236-2

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…For patients with high NIHSS scores, severe neurological deficits were already evident, and the low-flow STA-MCA bypass might not suffice to change their clinical outcome. Second, despite an improvement in postoperative hemodynamics observed in our study, STA-MCA bypass rarely prevented stroke recurrence, a significant factor contributing to poor outcomes in AIS-LVO patients [ 28 , 29 ]. Moreover, many of our patients underwent EVT, and interventional vascular procedures can lead to arterial injury, causing the release of pro-inflammatory factors into the bloodstream that may enter the brain and result in secondary brain tissue injury [ 30 ].…”

Section: Discussionmentioning

confidence: 83%

The clinical outcome of emergency superficial temporal artery-to-middle cerebral artery bypass in acute ischemic stroke with large vessel occlusion

Guo,

Yang,

et al. 2024

Neurosurg Rev

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The role of superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass in acute ischemic stroke (AIS) is contentious, with no evidence in patients with AIS and large vessel occlusion (AIS-LVO). We conducted a cohort study to assess emergency STA-MCA outcomes in AIS-LVO and a meta-analysis to evaluate STA-MCA outcomes in early AIS treatment. From January 2018 to March 2021, we consecutively recruited newly diagnosed AIS-LVO patients, dividing them into STA-MCA and non-STA-MCA groups. To evaluate the neurological status and outcomes, we employed the National Institutes of Health Stroke Scale (NIHSS) during the acute phase and the modified Rankin Scale (mRS) during the follow-up period. Additionally, we conducted a meta-analysis encompassing all available clinical studies to assess the impact of STA-MCA on patients with AIS. In the cohort study (56 patients), we observed more significant neurological improvement in the STA-MCA group at two weeks (p = 0.030). However, there was no difference in the clinical outcomes between the two groups. Multivariable logistic regression identified the NIHSS at two weeks (OR: 0.840; 95% CI: 0.754–0.936, p = 0.002) as the most critical predictor of a good outcome. Our meta-analysis of seven studies indicated a 67% rate for achieving a good outcome (mRS < 3) at follow-up points (95% CI: 57%–77%, I2 = 44.1%). In summary, while the meta-analysis suggested the potential role of STA-MCA bypass in mild to moderate AIS, our single-center cohort study indicated that STA-MCA bypass does not seem to improve the prognosis of patients who suffer from AIS-LVO.

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Section: Discussionmentioning

confidence: 83%

The clinical outcome of emergency superficial temporal artery-to-middle cerebral artery bypass in acute ischemic stroke with large vessel occlusion

Guo,

Yang,

et al. 2024

Neurosurg Rev

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“… 13 , 20 , 21 , 22 These observational studies have selection bias including immortal time bias because there was no random allocation and surgical groups might have misclassified immortal time. 13 , 16 , 22 , 23 , 24 , 25 , 26 , 27 …”

Section: Discussionmentioning

confidence: 99%

Association of Bypass Surgery and Mortality in Moyamoya Disease

Park,

Han,

Jang

et al. 2023

JAHA

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Background Patients with moyamoya disease (MMD) have a high risk of stroke or death. We investigated whether extracranial to intracranial bypass surgery can reduce mortality by preventing strokes in patients with MMD. Methods and Results This nationwide retrospective cohort study encompassed patients with MMD registered under the Rare Intractable Diseases program via the Relieved Co‐Payment Policy between 2006 and 2019, using the Korean National Health Insurance Service database. Following a 4‐year washout period, landmark analyses were employed to assess mortality and stroke occurrence between the bypass surgery group and the nonsurgical control group at specific time points postindex date (1 month and 3, 6, 12, and 36 months). The study included 18 480 patients with MMD (mean age, 40.7 years; male to female ratio, 1:1.86) with a median follow‐up of 5.6 years (interquartile range, 2.5–9.3; mean, 6.1 years [SD, 4.0 years]). During 111 775 person‐years of follow‐up, 265 patients in the bypass surgery group and 1144 patients in the nonsurgical control group died (incidence mortality rate of 618.1 events versus 1660.3 events, respectively, per 10 5 person‐years). The overall adjusted hazard ratio (HR) revealed significantly lower all‐cause mortality in the bypass surgery group from the 36‐month landmark time point, for any stroke mortality from 3‐ and 6‐month landmark time points, and for hemorrhagic stroke mortality from the 6‐month landmark time point. Furthermore, the overall adjusted HRs for hemorrhagic stroke occurrence were beneficially maintained from all 5 landmark time points in the bypass surgery group. Conclusions Bypass surgery in patients with MMD was associated with a lower risk of all‐cause and hemorrhagic stroke mortality and hemorrhagic stroke occurrence compared with nonsurgical control.

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Ischemic stroke following STA–MCA double bypass

Zhao

Tong

Wang

et al. 2022

Translational Neuroscience

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Objectives The surgical technique of STA–MCA double bypass is used to improve blood flow supplied by the distal middle cerebral artery (MCA) to the cerebral territory. This retrospective study from a single center aimed to compare the outcomes following STA–MCA double bypass in 12 patients with recurrent ischemic stroke. Materials and methods We retrospectively analyzed the data from patients with internal carotid artery occlusion (ICAO) who had undergone STA–MCA double bypass in our center from January 2016 to December 2020. The surgical indications, evaluation of circle of Willis (CoW), changes in cerebral hemodynamic, surgical results, and follow-up results were analyzed. Results Post-operative perfusion-weighted imaging showed hemodynamic improvement in all 12 patients. Ten patients (83.33%) showed clinical improvement, and 2 patients (16.67%) had stable disease. No intracranial infections or acute ischemic events occurred. The post-operative National Institutes of Health Stroke Scale score and modified Barther scores were significantly improved after 180 days of follow-up. Twenty three (96%) anastomoses maintain patency of their bypass vessels, and none had recurrent cerebral infarction during a minimum of 36 months follow-up. Conclusion In this small study, in patients with recurrent ischemic stroke without other types of treatment, STA–MCA double bypass surgery was more effective in the subgroup of patients with ICAO and poor blood supply to the CoW and an area of cerebral hypoperfusion that exceeded the area supplied by the MCA.

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The comparison of STA-MCA bypass and BMT for symptomatic internal carotid artery occlusion disease: a systematic review and meta-analysis of long-term outcome

Cited by 3 publications

References 21 publications

The clinical outcome of emergency superficial temporal artery-to-middle cerebral artery bypass in acute ischemic stroke with large vessel occlusion

The clinical outcome of emergency superficial temporal artery-to-middle cerebral artery bypass in acute ischemic stroke with large vessel occlusion

Association of Bypass Surgery and Mortality in Moyamoya Disease

Ischemic stroke following STA–MCA double bypass

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