The composition of red cell lipids and the activity of two enzymes of the erythrocyte membrane (ATPase and acetylcholinesterase) in primary refractory anemias

Palek, J; Brabec, V; Vopatová, M; Michalec, C; Mircevová, L

doi:10.1016/0009-8981(69)90019-9

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1969

1977

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Cited by 5 publications

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“…The clinical interest in red cell acetylcholinesterase (AChE) lies in the fact that this enzyme activity is below normal in almost every case of paroxysmal nocturnal haemoglobinuria [1,3] and in most cases of ABO haemolytic disease of the newborn [8,10] and of primary refractory anaemia [9]. A number of methods have been developed for this enzyme activity determination.…”

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confidence: 99%

Statistical Evaluation of the Determination of Red Cell Acetylcholinesterase Activity

Sirchia¹,

Ferrone²,

Marubini³

et al. 1970

Enzymol Biol Clin

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The dithiobisnitrobenzoic acid method for the determination of red cell acetylcholinesterase (AChE) activity, performed by means of a diagnostic ‘kit’, has been evaluated. The experimental design known as nested design has been used in order to determine the precision of the method and the influence that variability outside the laboratory (including the biological variability of each subject) has on the clinical significance of the results. It has been found that the most widely used procedure — i.e. one blood collection, one subsample, two replicates — can be considered satisfactory, since the AChE value obtained has a coefficient of variation of approximately nine.

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confidence: 99%