The Concept of Sequential Multicomponent Reactions: A Short Synthesis of Thiazolo- and Oxazolo[1,4]benzodiazepine-2,5-diones

Abstract

A new synthetic sequence including two sequential multicomponent reactions leading to a wide range of thiazolo-and oxazoloannulated benzodiazepinediones is described. This strategy features simple one-pot operations under mild conditions in combination with a high degree of diversity, and can be realized based on commercially available or easily accessible starting materials.

Selectivity in multiple multicomponent reactions: types and synthetic applications

“…Many additional combinations arise from the Union concept, such as Bredereck–Passerini [41], pyridone-cyclocondensation/Passerini–Ugi [42], azadiene-keteneimine Diels–Alder [43], Asinger–Ugi [44], etc.…”