2010
DOI: 10.1271/bbb.100157
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The Contribution ofArabidopsisHomologs ofL-Gulono-1,4-lactone Oxidase to the Biosynthesis of Ascorbic Acid

Abstract: To clarify the involvement of seven Arabidopsis homologs of rat L-gulono-1,4-lactone (L-GulL) oxidase, AtGulLOs, in the biosynthesis of L-ascorbic acid (AsA), transgenic tobacco cells overexpressing the various AtGulLOs were generated. Under treatment with L-GulL, the levels of total AsA in three transgenic tobacco cell lines, overexpressing AtGulLO2, 3, or 5, were significantly increased as compared with those in control cells.

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Cited by 58 publications
(59 citation statements)
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“…3). [20][21][22][23][24][25][26][27][28][29] Among them, the D-mannose/Lgalactose (D-Man/L-Gal) pathway plays a predominant role, at least in plant leaves. 9,20,21) In this pathway, GDP-D-Man is synthesized from D-fructose-6-phosphate (Fru-6P) in three steps, which are catalyzed by phosphomannose isomerase (PMI), phosphomannomutase, and GDP-D-Man pyrophosphorylase (GMP).…”
Section: Distribution and Biosynthesis Of Asamentioning
confidence: 99%
“…3). [20][21][22][23][24][25][26][27][28][29] Among them, the D-mannose/Lgalactose (D-Man/L-Gal) pathway plays a predominant role, at least in plant leaves. 9,20,21) In this pathway, GDP-D-Man is synthesized from D-fructose-6-phosphate (Fru-6P) in three steps, which are catalyzed by phosphomannose isomerase (PMI), phosphomannomutase, and GDP-D-Man pyrophosphorylase (GMP).…”
Section: Distribution and Biosynthesis Of Asamentioning
confidence: 99%
“…The last step leading to AsA is catalyzed by a L-gulono-1,4-lactone dehydrogenase/oxidase (GulLO). 40 Seven putative GulLO genes are present in the Arabidopsis genome. 40 Overexpression of these genes in tobacco BY2 cells pointed out that AtGulLO2, 3 and 5 encode functional enzymes.…”
Section: Sugars Ascorbate and Mitochondrial Ros Homeostasismentioning
confidence: 99%
“…40 Seven putative GulLO genes are present in the Arabidopsis genome. 40 Overexpression of these genes in tobacco BY2 cells pointed out that AtGulLO2, 3 and 5 encode functional enzymes. 40 The AtGulLO2 (At2g46750) and AtGulO5 (At2g46740) genes are highly expressed and the derived proteins are predicted to be located in mitochondria, 40 similar to L-galactono-1,4-lactone dehydrogenase AtHXK1-mediated effects such as hypocotyl elongation.…”
Section: Sugars Ascorbate and Mitochondrial Ros Homeostasismentioning
confidence: 99%
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“…Hence, it is possible that GLDH also plays a role in the oxidation of L-gulono-1,4-lactone, in an alternative, minor, ascorbate synthesizing pathway ( Fig. 1). [Although L-gulono-lactone oxidase activities have also been described in plants (33). ]…”
Section: Introductionmentioning
confidence: 99%