The Contribution of MMP-8 Promoter Polymorphisms in Lung Cancer

Shen, Te Chun; Hsia, Te Chun; Chao, Che Yi; Chen, Wei Cheng; Chen, Chih-Yu; Chen, Wei Chun; Lin, Yi Ting; Hsiao, Chieh Lun; Chang, Wen Shin; Tsai, Chia Wen; Bau, Da Tian

doi:10.21873/anticanres.11726

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…On the contrary to other studies, SNP rs17099462 decreased the expression of MMP8 and was shown to be associated with the increased risk of death from ovarian cancer [106]. MMP8 SNPs rs35866072 and rs34009635 have no effect on the risks of childhood acute lymphocytic leukemia [102], breast [94], bladder [90], oral [100] or lung cancer [104]. No MMP8 SNPs were correlated to nasopharyngeal carcinoma [101] or gastric cancer and its clinicopathological features [99].…”

Section: Resultsmentioning

confidence: 99%

“…In the case of HNSCC, no correlation between SNP rs11225395 and survival of the patients was found [78], nor was this SNP associated with risk of oral cancer [100]. Studies on the susceptibility to hepatocellular carcinoma [103], bladder cancer [90], acute lymphatic leukemia in children [102] and lung cancer [104] revealed no correlation to SNP rs11225395.…”

Section: Resultsmentioning

confidence: 99%

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The Role of MMP8 in Cancer: A Systematic Review

Juurikka

Butler

Salo

et al. 2019

IJMS

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Matrix metalloproteinases (MMPs) have traditionally been considered as tumor promoting enzymes as they degrade extracellular matrix components, thus increasing the invasion of cancer cells. It has become evident, however, that MMPs can also cleave and alter the function of various non-matrix bioactive molecules, leading to both tumor promoting and suppressive effects. We applied systematic review guidelines to study MMP8 in cancer including the use of MMP8 as a prognostic factor or as a target/anti-target in cancer treatment, and its molecular mechanisms. A total of 171 articles met the inclusion criteria. The collective evidence reveals that in breast, skin and oral tongue cancer, MMP8 inhibits cancer cell invasion and proliferation, and protects patients from metastasis via cleavage of non-structural substrates. Conversely, in liver and gastric cancers, high levels of MMP8 worsen the prognosis. Expression and genetic alterations of MMP8 can be used as a prognostic factor by examination of the tumor and serum/plasma. We conclude, that MMP8 has differing effects on cancers depending on their tissue of origin. The use of MMP8 as a prognostic factor alone, or with other factors, seems to have potential. The molecular mechanisms of MMP8 in cancer further emphasize its role as an important regulator of bioactive molecules.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Role of MMP8 in Cancer: A Systematic Review

Juurikka

Butler

Salo

et al. 2019

IJMS

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“…This study for breast cancer risk contained two different cohorts from Poland and the United Kingdom [23]. By implementing the predefined exclusion and inclusion criteria, 15 independent data sets were identified [13,16,23,24,25,26,27,28,29,30,31,32,33,34]. In total, 7375 cancer samples and 8117 controls were included.…”

Section: Resultsmentioning

confidence: 99%

The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis

et al. 2019

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This meta-analysis aimed to systematically review the evidence on cancer risk of the MMP-8 rs11225395 promoter polymorphism. Relevant studies published by 12 June 2019 were identified by systematically searching PubMed, Web of Science, Cochrane Library, CNKI and Wanfang databases. R programs and STATA software were used to calculate odds ratio (OR) and 95% confidence interval (CI). In total, 7375 cancer samples and 8117 controls were included by integrating 15 case-control data sets. Pooled estimates from the statistical analysis revealed no statistical significance for the association between this polymorphism and cancer risk. All pooled estimates resulting from subgroup analyses by cancer type and sample size were not materially altered and did not draw significantly different conclusions. The stratified analyses according to geographic region showed the statistical significance for increased cancer risk of the MMP-8 rs11225395 polymorphism in non-Asian populations under the allele model (OR = 1.11, 95% CI: 1.04–1.19), homozygote model (OR = 1.22, 95% CI: 1.05–1.41), heterozygote model (OR = 1.21, 95% CI: 1.07–1.36), and dominant model (OR = 1.21, 95% CI: 1.08–1.35). However, no statistical significance was detected in Asian populations. In conclusion, these findings suggested that the MMP-8 rs11225395 polymorphism is associated with elevated susceptibility to cancer in non-Asian populations.

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“…More efficient investigations are still required to further strengthen the statistical power. Last but not least, P value for HWE was less than 0.05 in five of the included articles [30, 31, 33–35], which might be exposed to unknown bias factors.…”

Section: Discussionmentioning

confidence: 99%

MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not related to risk of cancer

et al. 2019

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BackgroundSeveral studies have focused on the relationship between MMP-8 variants and cancer risk, but they have been unsuccessful in drawing reliable conclusions.MethodsWe employed odds ratio (OR) together with 95% confidence interval (CI) to assess the correlation between MMP-8 C-799 T, Lys460Thr, and Lys87Glu polymorphisms and cancer risk. We further employed in silico tools to evaluate the effect of MMP-8 expression on cancer susceptibility and overall survival time.ResultsA total of 8140 patients with malignant carcinoma and 10,529 healthy individuals (control) were enrolled. Overall, the analysis showed that the relationship between three MMP-8 variants and cancer susceptibility was not significant (allelic contrast, C-799 T: OR = 0.98, 95% CI = 0.92–1.04, Pheterogeneity = 0.068; Lys460Thr: OR = 0.94, 95% CI = 0.67–1.32, Pheterogeneity = 0.905; Lys87Glu: OR = 1.05, 95% CI = 0.93–1.18, Pheterogeneity = 0.968). Similar results were observed in subgroup analysis by ethnicity, cancer type, and source of control. In silico analysis indicated that MMP-8 expression was elevated in bladder cancer tissue compared to that in the control. However, both the higher and lower MMP-8 expression groups did not show an impact on the overall survival time of the patients.ConclusionsMMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not participant with the susceptibility of cancer.

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The Contribution of MMP-8 Promoter Polymorphisms in Lung Cancer

Abstract: The polymorphisms MMP-8 C-799T, Val436Ala and Lys460Thr may not play a major role in mediating personal susceptibility to lung cancer in Taiwan.

Cited by 14 publications

References 16 publications

The Role of MMP8 in Cancer: A Systematic Review

The Role of MMP8 in Cancer: A Systematic Review

The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis

MMP-8 C-799 T, Lys460Thr, and Lys87Glu variants are not related to risk of cancer

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