The Contribution to Venous Admixture by Shunting through the Ductus Arteriosus in Infants with the Respiratory Distress Syndrome of the Newborn

Alveolar to Arterial Oxygen Tension Difference and Venous Admixture in Newly Born Infants with Congenital Diaphragmatic Herniation through the Foramen of Bochdalek

“…The P 0 2 difference between the radial artery and the descending aortic samples usually decreased with increasing age as has been recent ly reported in infants with the Respiratory Distress Syndrome [9].…”

“…The alveolar oxygen tension (P a 0 2) was then calculated from the alveolar air equa tion previously described [9]. The difference between the partial pressure of oxygen in the alveolar gas and the arterial blood (A -aD 02) was determined:…”

“…We have recently studied the contribution of the ductus arterious as a site of venous admixture in premature infants with the Respiratory Distress Syndrome [9]. There are no data available on the role of the ductus arteriosus as a site of R -> L shunting in infants with congenital diaphragmatic herniae.…”

Position of the Oxygen Dissociation Curve in Newborns with Transitory Hyperbilirubinaemia

“…aemia on the third day, the oxygen dissociation curve shows a shift to the left. A similar shift of the oxygen dissociation curve was found in children with respiratory distress syndrome [7]; this may be explained by a chronic acidosis and by enlarged shunting of the blood in the lungs [5,12].…”

Circulatory Studies in Clinical Hyaline Membrane Disease

“…Ideally, one would wish to be able to have an accurate quanti tation of pulmonary and systemic blood flow, of pulmonary and systemic re sistance, and to measure their changes with changing status and therapeutic measures. Attempts have been made in a few instances to quantitate pulmo nary blood flow accurately in these infants, and to assess the magnitude of intra-vs. extra-pulmonary shunting [2,10,20]. Methodology for measuring pulmonary blood flow in the presence of shunts has required either a firm catheter with which the pulmonary artery can be entered and blood sampled on either side of the ductus arteriosus, or the use of inert gas inhalation [2].…”