Objectives: To investigate the effects of smartphone overuse on headache, sleep quality, daytime sleepiness and quality of life in migraine patients. Methods: This study is a single-center, cross sectional comparative study. This study was conducted between July and September 2017 in the Neurology Clinic of a private hospital. Migraine disability assessment)MIDAS(questionnaire was used to evaluate the disability status, and Mobile Phone Problematic Use Scale)MPPUS(was used to evaluate smartphone use frequency. The Visual Analogue Scale)VAS(, 24-h Migraine Quality of Life Questionnaire)24-h MQoLQ(, Pittsburgh Sleep Quality Index)PSQI(and Epworth Sleepiness Scale)ESS(were used to evaluate the pain intensity, quality of life, sleep quality and daytime sleepiness, respectively. Results: The study included a total of 123 patients. There was a significant difference between the groups in terms of pain intensity, frequency and duration as well as VAS, PSQI, 24-h MQoLQ and ESS)p<0.05(scores. There was a negative correlation between MPPUS and PSQI)r=−0.367, p<0.05(; a strong positive correlation between MPPUS and ESS)r=0.675, p<0.05(and a negative correlation between MPPUS and 24-h MQoLQ)r=−0.508, p<0.05(. Conclusion: Smartphone use has been observed to increase headache duration and frequency in migraine patients. Its overuse in migraine patients is related to poor sleep quality and daytime sleepiness; furthermore, as the smartphone use increases, sleep quality decreases, daytime sleepiness increases and quality of life decreases.