The crystal structure of bacteriophage GA and a comparison of bacteriophages belonging to the major groups of Escherichia coli leviviruses

Tars, K.; Bundule, M. F.; Fridborg, K.; Liljas, Lars

doi:10.1006/jmbi.1997.1214

Cited by 73 publications

(48 citation statements)

References 41 publications

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“…STMV (satellite tobacco mosaic virus) has been used as an example of a T ¼ 1 virus, and our results are in good agreement with the RNA fragments represented in its PDB file (PDB id 1a34; Larson et al, 1998). We have shown that bacteriophage GA (PDB id 1gav; Tars et al, 1997), which is in a different group in the same family as MS2, has the same best-fit point array, showing that the structures of two evolutionarily related viruses are represented by the same point array in our classification.…”

Section: Application To a Wide Range Of Virusessupporting

confidence: 82%

Structural constraints on the three-dimensional geometry of simple viruses: case studies of a new predictive tool

Keef

Wardman

Ranson

et al. 2013

Acta Crystallogr A Found Crystallogr

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Understanding the fundamental principles of virus architecture is one of the most important challenges in biology and medicine. Crick and Watson were the first to propose that viruses exhibit symmetry in the organization of their protein containers for reasons of genetic economy. Based on this, Caspar and Klug introduced quasi-equivalence theory to predict the relative locations of the coat proteins within these containers and classified virus structure in terms of T-numbers. Here it is shown that quasi-equivalence is part of a wider set of structural constraints on virus structure. These constraints can be formulated using an extension of the underlying symmetry group and this is demonstrated with a number of case studies. This new concept in virus biology provides for the first time predictive information on the structural constraints on coat protein and genome topography, and reveals a previously unrecognized structural interdependence of the shapes and sizes of different viral components. It opens up the possibility of distinguishing the structures of different viruses with the same T-number, suggesting a refined viral structure classification scheme. It can moreover be used as a basis for models of virus function, e.g. to characterize the start and end configurations of a structural transition important for infection.

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Section: Application To a Wide Range Of Virusessupporting

confidence: 82%

Structural constraints on the three-dimensional geometry of simple viruses: case studies of a new predictive tool

Keef

Wardman

Ranson

et al. 2013

Acta Crystallogr A Found Crystallogr

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show abstract

“…The genomes of fr and GA are 85 and 74% identical to that of MS2, respectively, while the capsid proteins are 87 and 62% homologous, respectively (see Fig. S1 in the supplemental material) (20). Differences in the A protein composition are more pronounced, with MS2 and fr exhibiting 78% homology and MS2 and GA exhibiting 38% homology.…”

mentioning

confidence: 99%

Subtle Differences in Virus Composition Affect Disinfection Kinetics and Mechanisms

Sigstam

Gannon

Cascella

et al. 2013

Appl Environ Microbiol

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“…Three-dimensional structures determined for virions Q␤ (10), MS2 (31), fr (17), GA (28), and PP7 (29) allowed threading of the PRR1 coat protein sequence to available structures. With the exceptions of MS2 and fr, the overall sequence similarity between different coat proteins was Ͻ30%.…”

mentioning

confidence: 99%

Complete Genome Sequence of the Broad Host Range Single-Stranded RNA Phage PRR1 Places It in the Levivirus Genus with Characteristics Shared with Alloleviviruses

Ruokoranta

Grahn

Ravantti

et al. 2006

J Virol

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Single-stranded RNA (ssRNA) bacteriophages of the family Leviviridae infect gram-negative bacteria. They are restricted to a single host genus. Phage PRR1 is an exception, having a broad host range due to the promiscuity of the receptor encoded by the IncP plasmid. Here we report the complete genome sequence of PRR1. Three proteins homologous with those of other ssRNA phages, i.e., maturation, coat, and replicase proteins, were identified. A fourth protein has a lysis function. Comparison of PRR1 with other members of the Leviviridae family places PRR1 in the genus Levivirus with some characteristics more similar to those of members of the genus Allolevivirus.

show abstract

The crystal structure of bacteriophage GA and a comparison of bacteriophages belonging to the major groups of Escherichia coli leviviruses

Cited by 73 publications

References 41 publications

Structural constraints on the three-dimensional geometry of simple viruses: case studies of a new predictive tool

Structural constraints on the three-dimensional geometry of simple viruses: case studies of a new predictive tool

Subtle Differences in Virus Composition Affect Disinfection Kinetics and Mechanisms

Complete Genome Sequence of the Broad Host Range Single-Stranded RNA Phage PRR1 Places It in the Levivirus Genus with Characteristics Shared with Alloleviviruses

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