The Decline of the Immune Response during Aging: the Role of an Altered Lipid Metabolism<sup>a</sup>

Wick, Georg; Huber, Lukas A.; Xu, Qingbo; Jarosch, E; Schönitzer, Diether; Jürgens, Günther

doi:10.1111/j.1749-6632.1991.tb16986.x

Cited by 30 publications

(11 citation statements)

References 45 publications

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“…And although a few reports show correlations among biological processes, these studies did not focus on the systems level (Yamada et al 2003;Wick et al 1991). In our current study, we found opposite expressional patterns between the immune response and lipid metabolism based on the large-scale expression profiles.…”

Section: Discussionmentioning

confidence: 97%

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Hong

Heo

Kim

et al. 2009

AGE

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Although systems biology is a perfect framework for investigating system-level declines during aging, only a few reports have focused on a comprehensive understanding of system-level changes in the context of aging systems. The present study aimed to understand the most sensitive biological systems affected during aging and to reveal the systems underlying the crosstalk between aging and the ability of calorie restriction (CR) to effectively slow-down aging. We collected and analyzed 478 aging- and 586 CR-related mouse genes. For the given genes, the biological systems that are significantly related to aging and CR were examined according to three aspects. First, a global characterization by Gene Ontology (GO) was performed, where we found that the transcriptome (a set of genes) for both aging and CR were strongly related in the immune response, lipid metabolism, and cell adhesion functions. Second, the transcriptional modularity found in aging and CR was evaluated by identifying possible functional modules, sets of genes that show consistent expression patterns. Our analyses using the given functional modules, revealed systemic interactions among various biological processes, as exemplified by the negative relation shown between lipid metabolism and the immune response at the system level. Third, transcriptional regulatory systems were predicted for both the aging and CR transcriptomes. Here, we suggest a systems biology framework to further understand the most important systems as they age.

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Section: Discussionmentioning

confidence: 97%

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Hong

Heo

Kim

et al. 2009

AGE

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“…These cells can be rescued by exogenous LDL in a saturable, receptor-mediated fashion or by high doses of HDL in a nonreceptor-mediated fashion as a cholesterol source. Furthermore, characteristic changes in membrane composition occur during mitogen stimulation of T cells with an altered switch in hpid composition during blast transformation in the elderly (54), The stimulation-associated changes in membrane lipid composition differ in the elderly in comparison to young controls with respect to cholesterol, total phospholipids, phosphatidylethanolamine and several fatty acids. Moreover, the age-related alterations in the switch of membrane lipids and fatty acids are significantly correlated with a decreased mitogen response.…”

Section: Memorymentioning

confidence: 99%

Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease

Wick

Grubeck‐Loebenstein

1997

Immunological Reviews

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The function of the immune system declines with age. It is the aim of the present review to demonstrate that it makes sense to distinguish between primary and secondary alterations of immune reactivity in the elderly. Primary changes occur as the result of an age-dependent intrinsic decline of immune responsiveness. They also occur in healthy persons, i.e. persons selected according to the criteria of the SENIEUR protocol of the European Community's Concerted Action Program on Aging (EURAGE). T lymphocytes are hereby more severely affected than B cells or antigen presenting cells, possibly due to the involution of the thymus, which is almost complete at the age of 60. Secondary immunological changes occur as the result of environmental factors including diet, drug intake, physical activity etc. or are alternatively due to underlying diseases. In this article, the effects of high lipid intake as well as the impact of diseases, such as for instance Alzheimer's disease and atherosclerosis, will be addressed. The results underline the complexity of immunological alterations to be expected in old age. Changes in the aging immune system represent an opportunity for increased frequency and severity of disease and endanger the protective effect of vaccination.

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“…The immune system of the elderly is characterized by a decreased response to exogenous anti gens associated with an increased frequency o f autoimmune phenomena primarily affecting T cells [1], Apart from ex trinsic alterations, e.g. general age-related metabolic chang es or underlying disease, the immune system of the elderly is affected by intrinsic alterations.…”

Section: Introductionmentioning

confidence: 99%

Reference Intervals for Human Peripheral Blood Lymphocyte Subpopulations from ‘Healthy’ Young and Aged Subjects

Stulnig

Maczek

Böck

et al. 1995

Int Arch Allergy Immunol

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Some lymphocyte subpopulations change during aging but age-related reference limits from a healthy reference population are still lacking. In this study, we compiled 90% reference intervals for commonly determined lymphocyte subpopulations in ‘healthy’ (Senieur-compatible) young (20–32 years) and elderly (65–74 years) subjects. The most striking age-related changes included increases in HLA-DR+ T lymphocytes, and the shift in the expression of CD45 isoforms from the CD45RA+CD45RO–– to the CD45RA––CD45RO+ subset. Both age-related alterations occurred in the CD4+ as well as in the CD8+ subpopulations and most of them were present in the relative and absolute number of lymphocyte subsets. We compare our data with those from previous investigations on lymphocyte subpopulations from the elderly and comment on useful presentation of reference values.

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The Decline of the Immune Response during Aging: the Role of an Altered Lipid Metabolism^a

Cited by 30 publications

References 45 publications

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease

Reference Intervals for Human Peripheral Blood Lymphocyte Subpopulations from ‘Healthy’ Young and Aged Subjects

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The Decline of the Immune Response during Aging: the Role of an Altered Lipid Metabolisma

Cited by 30 publications

References 45 publications

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome

Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease

Reference Intervals for Human Peripheral Blood Lymphocyte Subpopulations from ‘Healthy’ Young and Aged Subjects

Contact Info

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The Decline of the Immune Response during Aging: the Role of an Altered Lipid Metabolism^a