The density, viscosity and structural properties of aqueous ethambutol hydrochloride solutions

Abstract

Ethambutol (EMB) is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis. It is bacteriostatic against actively growing TB bacilli. The density and viscosity of aqueous ethambutol hydro chloride solutions have been studied at 298.15, 301.15 and 304.15 K and at different concentrations (0.255, 0.168, 0.128, 0.087, 0.041, and 0.023 mol dm -3 ). The apparent molar volume of these solutions for different temperatures and concentrations was calculated from the density data. The relative viscosities of drug solu tions have been analysed by Jones-Dole equation. The limiting apparent molar volumes have been evaluated for different temperatures. The different properties have been used to study structural properties, structure formation and breaking properties of drug and solute-solvent interactions in solutions.

Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

“…The drug-solvent interactions have been studied (Deosarkar et al, 2014;Deosarkar et al, 2014;Deosarkar and Kalyankar, 2013;Deosarkar et al, 2012). An effort has been made here to study the physicochemical properties such as density, refractive index and apparent and partial molar volumes of metoclopramide hydrochloride in water, DMSO and 30, 50 and 70% v/v DMSO-water mixtures.…”