The Developing Utility of Zebrafish Models for Cognitive Enhancers Research

Stewart, Adam; Kalueff, Allan V.

doi:10.2174/157015912803217323

Cited by 45 publications

(20 citation statements)

References 161 publications

(173 reference statements)

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“…Likewise, aging-related psychiatric disorders and cognitive decline are receiving growing recognition in clinical psychiatry, and have recently been successfully modeled in zebrafish 110, 111 . Bidirectional sensitivity of cognitive phenotypes to various pharmacological modulators 70, 110–112 further supports the value of zebrafish in this research. The growing interest in using zebrafish to study pathogenic overlap between behavioral and metabolic disorders 113 is also encouraging, and merits further analyses.…”

Section: Critical Evaluation and Future Directionssupporting

confidence: 69%

Zebrafish as an emerging model for studying complex brain disorders

Kalueff¹,

Stewart

Gerlai

2014

Trends in Pharmacological Sciences

933

642

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The zebrafish (Danio rerio) is rapidly becoming a popular model organism in pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently used to increase our understanding of brain function, dysfunction, and their genetic and pharmacological modulation. Here we review the developing utility of zebrafish in the analysis of complex brain disorders (including, for example, depression, autism, psychoses, drug abuse and cognitive disorders), also covering zebrafish applications towards the goal of modeling major human neuropsychiatric and drug-induced syndromes. We argue that zebrafish models of complex brain disorders and drug-induced conditions have become a rapidly emerging critical field in translational neuropharmacology research.

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Section: Critical Evaluation and Future Directionssupporting

confidence: 69%

Zebrafish as an emerging model for studying complex brain disorders

Kalueff¹,

Stewart

Gerlai

2014

Trends in Pharmacological Sciences

933

642

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“…Zebrafish as an alternative to existing animal models is gaining popularity in the field of cognitive research. There are several reports which provide strong evidence on the usefulness of zebrafish model for studying cognitive functions ( Stewart and Kalueff, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach

et al. 2017

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Epilepsy is a neuronal disorder allied with distinct neurological and behavioral alterations characterized by recurrent spontaneous epileptic seizures. Impairment of the cognitive performances such as learning and memory is frequently observed in epileptic patients. Anti-epileptic drugs (AEDs) are efficient to the majority of patients. However, 30% of this population seems to be refractory to the drug treatment. These patients are not seizure-free and frequently they show impaired cognitive functions. Unfortunately, as a side effect, some AEDs could contribute to such impairment. The major problem associated with conducting studies on epilepsy-related cognitive function is the lack of easy, rapid, specific and sensitive in vivo testing models. However, by using a number of different techniques and parameters in the zebrafish, we can incorporate the unique feature of specific disorder to study the molecular and behavior basis of this disease. In the view of current literature, the goal of the study was to develop a zebrafish model of epilepsy induced cognitive dysfunction. In this study, the effect of AEDs on locomotor activity and seizure-like behavior was tested against the pentylenetetrazole (PTZ) induced seizures in zebrafish and epilepsy associated cognitive dysfunction was determined using T-maze test followed by neurotransmitter estimation and gene expression analysis. It was observed that all the AEDs significantly reversed PTZ induced seizure in zebrafish, but had a negative impact on cognitive functions of zebrafish. AEDs were found to modulate neurotransmitter levels, especially GABA, glutamate, and acetylcholine and gene expression in the drug treated zebrafish brains. Therefore, combination of behavioral, neurochemical and genenetic information, makes this model a useful tool for future research and discovery of newer and safer AEDs.

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“…Zebrafish is already being used to study memory-inhibiting drugs, as well as agents thought to enhance cognitive performance [61]. The impact of the socially-relevant stimulant, nicotine, on cognitive function, for example, can be effectively studied using zebrafish [62] with the ability of bridging biology with behavior, in this case understanding brain receptor activity [63].…”

Section: Effects Of Anesthetic Agentsmentioning

confidence: 99%

Modeling Post-Operative Cognitive Dysfunction in Zebrafish

McElroy¹,

Mustard²,

Kamran³

et al. 2016

AAD

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Permanent post-operative cognitive dysfunction (POCD) is a grim outcome to an estimated 6% of elderly surgical patients. Volatile anesthetics impact neuronal tissue independent of effects attributed to the physical trauma of the surgery itself. While it is recognized that all aspects related to surgery may contribute to cognitive loss in some manner, the present paper focuses on the role of volatile anesthetics in promoting POCD. There is an increased risk of onset and progression of Alzheimer's disease (AD) from POCD, implying that the neuropathogenesis between the two is similar. Human studies, being ethically limited in scope, require animal models as a substitute. While the literature using rodent models contains valuable information, we believe that the accessible and practical zebrafish will greatly enhance our further understanding of the molecular mechanism of POCD as it relates to AD. Disease genes and fundamental neurobehaviors of these teleost fish mirror those of mammals and humans, validating their use as a core research model for AD. Since the gradual senescence seen in zebrafish also resembles that found in humans, we numerically correlated the two lifespans, offering researchers a computational tool. Zebrafish, being aquatic animals, necessitates the use of miscible compounds, such as trifluoroethanol, whose anesthetic potency we are presenting. We also review the rodent and zebrafish literature relevant to POCD. Continued research with the leading-edge zebrafish unlocks the possibility that, in the future, perioperative intervention will prevent POCD.

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The Developing Utility of Zebrafish Models for Cognitive Enhancers Research

Cited by 45 publications

References 161 publications

Zebrafish as an emerging model for studying complex brain disorders

Zebrafish as an emerging model for studying complex brain disorders

Zebrafish as a Model for Epilepsy-Induced Cognitive Dysfunction: A Pharmacological, Biochemical and Behavioral Approach

Modeling Post-Operative Cognitive Dysfunction in Zebrafish

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