The diagnostic and prognostic value of 18F-FDG PET/CT in the initial assessment of high-grade bone and soft tissue sarcoma. A retrospective study of 89 patients

Fuglo, Hanna Maria; Jørgensen, Simon Møller; Loft, Annika; Hovgaard, Dorrit; Petersen, Michael Mørk

doi:10.1007/s00259-012-2159-z

Cited by 101 publications

(64 citation statements)

References 27 publications

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“…To more confidently conclude that FDG PET/CT findings can indicate therapeutic response and clinical outcome, more comprehensive studies are needed to determine whether similar trends can be seen in other cases of DSRCT. These findings are, however, consistent with those of other studies involving FDG PET/CT evaluation of sarcomas that indicate that tumor FDG uptake can be an indicator of prognosis [26, 27]. In a recent report, Arora et al [25] described their experience using FDG PET/CT in the staging and followup of 11 patients with DSRCT.…”

Section: Discussionsupporting

confidence: 86%

FDG PET/CT imaging of desmoplastic small round cell tumor: findings at staging, during treatment and at follow-up

et al. 2015

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Section: Discussionsupporting

confidence: 86%

FDG PET/CT imaging of desmoplastic small round cell tumor: findings at staging, during treatment and at follow-up

et al. 2015

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“…Also, a positive correlation between the overexpression of GLUT-1 and 18 F-FDG avidity has been reported [28,29]. All these findings could explain the relationship between FDG uptake on PET and tumor aggressiveness [30], and thus prognosis in cancer [13,[31][32][33][34]. In fact, PET has been used for diagnosis, staging, and determining the treatment response of malignancies.…”

Section: Discussionmentioning

confidence: 90%

The Role of 18F-FDG PET/CT as a Prognostic Factor in Patients with Synovial Sarcoma

Chang

Lim

Park

et al. 2014

Nucl Med Mol Imaging

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Purpose This research aims to investigate the potential of 18 Ffluorodeoxyglucose positron emission tomography/computed tomography (FDG PET) to predict pathologic response after neoadjuvant chemotherapy (NAC) and overall survival (OS) of patients with synovial sarcoma in Korea. Methods Twenty patients with synovial sarcoma from January 2001 to December 2011 were reviewed retrospectively. All patients underwent pre-treatment FDG PET and tumor removal. Patients were classified with the maximum SUV (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), age, sex, histologic subtype, tumor size, NAC, resection margin, and metastasis at diagnosis. Pathologic response was assessed using the French Federation of Cancer Centers system. Statistical analyses were analyzed using the Kaplan-Meier method, log-rank test, Cox proportional hazards regression model, and Mann-Whitney test. Results Nine patients (45 %) showed pathologic response, and ten patients survived. Higher SUVmax, higher MTV, higher TLG, monophasic epithelial type, and metastasis at diagnosis were significantly related to poorer OS (p=0.047, 0.016, 0.016, 0.045, and 0.018, respectively). By multivariate analysis, metastasis at diagnosis was significantly related to poorer OS (p=0.012/HR=5.9, 95 % CI 1.47 to 24.1). The SUVmax, MTV, and TLG of the non-responder group were significantly higher than those of the responder group (p= 0.020, 0.020, and 0.020, respectively). There was no significant difference in size between the two groups (p=0.062). Conclusions A higher SUVmax on the pre-treatment scan, monophasic epithelial type, and metastasis at diagnosis were significantly associated with a poorer OS, and pathologic responders showed a higher SUVmax before NAC. The PET parameters can be used to predict OS and pathologic response in patients with synovial sarcomas before NAC.

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“…Of the 1,310 articles screened, 16 (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) were selected for the final analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta-analysis

Muheremu

Amudong

et al. 2017

Molecular and Clinical Oncology

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Abstract. In order to elucidate the value of positron emission tomography (PET)/computed tomography (CT) in the clinical diagnosis and treatment of osseous and soft tissue malignancies, two authors independently searched the PubMed, Medline, Elsevier, Embase and Cochrane Library databases for literature published between January 2003 and February 2016, using the key words 'PET/CT', 'positron emission tomography/computed tomography', 'osseous sarcoma', 'bone tumor', 'soft tissue sarcoma' and 'neoadjuvant', to identify prospective and retrospective studies on the applicability of PET/CT on the clinical diagnosis of bone and soft tissue lesions, and evaluation of their response to neoadjuvant therapies. Data were independently extracted by the two authors and any disagreements were resolved by a third author when necessary. Extracted data were analyzed by Meta-Disc 1.6 software. As a result, 16 trials with a total of 883 patients and 2,214 lesions were included in the present study. The overall diagnostic accuracy of PET/CT exhibited a sensitivity and specificity of 0.90 (0.86-0.92) and 0.89 (0.85-0.92), respectively, and the effect of neoadjuvant therapy was assessed with a sensitivity and specificity of 0.79 (0.30-0.93) and 0.79 (0.69-0.89), respectively. Thus, it may be concluded from the present study that PET/CT is a reliable imaging method to be applied in the diagnosis and treatment of osseous and soft tissue malignancies.

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The diagnostic and prognostic value of 18F-FDG PET/CT in the initial assessment of high-grade bone and soft tissue sarcoma. A retrospective study of 89 patients

Abstract: FDG PET/CT for the initial assessment of patients with high-grade BS or STS was feasible with high SE and SP, but in those with lymph node metastases the PV of a positive test was low. The SUVmax of the primary tumour was a strong prognostic factor for survival.

Cited by 101 publications

References 27 publications

FDG PET/CT imaging of desmoplastic small round cell tumor: findings at staging, during treatment and at follow-up

FDG PET/CT imaging of desmoplastic small round cell tumor: findings at staging, during treatment and at follow-up

The Role of 18F-FDG PET/CT as a Prognostic Factor in Patients with Synovial Sarcoma

Positron emission tomography/computed tomography for osseous and soft tissue sarcomas: A systematic review of the literature and meta-analysis

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