The differences of the metabolism related to vitamin B6-dependent enzymes among vitamin B6-deficient germ-free and conventional rats.

Ikeda, Masamichi; Hosotani, Tokuji; K, Kurimoto; Mori, T; Ueda, Takashi; Kotake, Yahito; Sakakibara, Bunsaku

doi:10.3177/jnsv.25.131

Cited by 14 publications

(4 citation statements)

References 14 publications

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“…These experiments quickly indicated that one fundamental service of the gut microbiota is production of vitamins for the host. Indeed, early studies emphasized the requirement for increased dietary vitamin K, B 1 (thiamin), B 6 (pyridoxine), B 7 (biotin), B 9 (folic acid) and B 12 (cobalamin) for the health of germfree animals (Ikeda et al, 1979; Sumi et al, 1977; Wostmann, 1981; Wostmann and Knight, 1965). Members of the genera Bifidobacterium and Lactobacillus may play important roles in this regard (Lozupone et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Vitamin B 12 as a Modulator of Gut Microbial Ecology

2014

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The microbial mechanisms and key metabolites that shape the composition of the human gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial communities towards stability and health. Vitamins, which by definition are not synthesized in sufficient quantities by the host and can mediate fundamental biological processes in microbes, represent an attractive target for reshaping microbial communities. Here, we discuss how vitamin B12 (cobalamin) impacts diverse host-microbe symbioses. Although cobalamin is synthesized by some human gut microbes, it is a precious resource in the gut and is likely not provisioned to the host in significant quantities. However, this vitamin may make an unrecognized contribution in shaping the structure and function of human gut microbial communities.

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Section: Introductionmentioning

confidence: 99%

Vitamin B 12 as a Modulator of Gut Microbial Ecology

2014

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“…Gut microbiota is regarded as an integral component of the host because of its important role in host digestion and health (Sommer and Bäckhed, 2013;Sonnenburg and Bäckhed, 2016). Studies in humans and other vertebrates have revealed that gut microbiota produces many metabolites, including short-chain fatty acids (Immerseel et al, 2010), essential vitamins and amino acids (Ikeda et al, 1979;Ramotar et al, 1984;Lozupone et al, 2012;Mardinoglu et al, 2015), as well as some digestive enzymes (Yolton and Savage, 1976;Dabek et al, 2008;Carmody and Turnbaugh, 2014) that are beneficial to the host. The microbiomes of terrestrial invertebrates, especially insects such as wasps (Adams et al, 2011), flies (Erkosar et al, 2013), termites (Poulsen et al, 2014), and beetles (Salem et al, 2017), have been studied and shown to be involved in host nutrient acquisition provided by symbiotic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Gut Microbiota Between Golden and Brown Noble Scallop Chlamys nobilis and Its Association With Carotenoids

et al. 2020

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Many marine bivalves are regarded as healthy foods due to their high carotenoid content. Only plants and microorganisms have natural carotenoids biosynthesis ability, hence, animals such as bivalves must obtain carotenoids from their diets. Due to the filter-feeding behavior of bivalves, they have high diversity of gut microbes. However, the relationship between gut microbes and carotenoids has not been explored in mollusks. In the present study, the interaction between gut microbes and carotenoids in two polymorphic noble scallop Chlamys nobilis, golden scallops (designated GG) and brown scallops (designated BW), were studied. The gut of GG and BW showed statistically different bacteria communities. Results from 16S rRNA gene sequencing and qPCR analysis revealed that the gut of GG had significantly higher relative abundance of carotenoids-producing bacteria Brevundimonas, compared with BW. Moreover, HPLC-MS analysis showed that isolate Brevundimonas could produce astaxanthin. The current findings are very useful as they could form the basis for future studies in determining the relationship between gut microbiota and carotenoids absorption in bivalves.

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“…Gut microbiota synthesize choline, thiamin (vitamin B1), vitamin B2, nicotinic acid (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate, and B12 [7,8]. Prior studies have shown an increased requirement for dietary vitamins K, B1, B6, B7, B9 and B12 to maintain health in germ-free mice [9,10]. Systemic research assessed the genomes of 256 common human-gut bacteria for the presence of the biosynthesis pathways for eight B-vitamins.…”

Section: Introductionmentioning

confidence: 99%

Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon

et al. 2019

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One carbon (1C) metabolism nutrients influence epigenetic regulation and they are supplied by diet and synthesized by gut microbiota. We examined the association between dietary consumption of methyl donors (methionine, betaine and choline) and B vitamins (folate, B2, B6, and B12) and the community composition and structure of the colonic mucosa-associated gut microbiota determined by 16S rRNA gene sequencing in 97 colonic biopsies of 35 men. We used the food frequency questionnaire to assess daily consumption of nutrients, and the UPARSE and SILVA databases for operational taxonomic unit classification. The difference in bacterial diversity and taxonomic relative abundance were compared between low versus high consumption of these nutrients. False discover rate (FDR) adjusted p value < 0.05 indicated statistical significance. The bacterial richness and composition differed significantly by the consumption of folate and B vitamins (p < 0.001). Compared with higher consumption, a lower consumption of these nutrients was associated with a lower abundance of Akkermansia (folate), Roseburia (vitamin B2), and Faecalibacterium (vitamins B2, B6, and B12) but a higher abundance of Erysipelatoclostridium (vitamin B2) (FDR p values < 0.05). The community composition and structure of the colonic bacteria differed significantly by dietary consumption of folate and B vitamins.

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The differences of the metabolism related to vitamin B6-dependent enzymes among vitamin B6-deficient germ-free and conventional rats.

Abstract: SummaryThe differences of the metabolism related to vitamin B6-dependent enzymes were investigated using germ-free and conventional rats.

Cited by 14 publications

References 14 publications

Vitamin B 12 as a Modulator of Gut Microbial Ecology

Vitamin B 12 as a Modulator of Gut Microbial Ecology

Comparison of Gut Microbiota Between Golden and Brown Noble Scallop Chlamys nobilis and Its Association With Carotenoids

Dietary Nutrients Involved in One-Carbon Metabolism and Colonic Mucosa-Associated Gut Microbiome in Individuals with an Endoscopically Normal Colon

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