The distribution and latency of the auditory P300 in schizophrenia and depression

Weir, Neville; Fiaschi, Kathia; Machin, David

doi:10.1016/s0920-9964(98)00017-6

Cited by 28 publications

(13 citation statements)

References 38 publications

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“…General slowing of EEG frequencies has been reported as a consequence of neuroleptic medication, but differences in slow wave activity in patients on and off neuroleptics might be the consequence of medication or of symptom differences [73]. The latency in P300 does not appear to be related to medication [74], and changes in P300 amplitude do not seem to be affected by antipsychotic medication [8]. Attenuation of the P300 in the frontal areas was greater in unmedicated patients and during the first episode of schizophrenia [75].…”

Section: Discussionmentioning

confidence: 99%

Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia

Fujimoto¹,

Okumura²,

Takeuchi³

et al. 2013

Open Neuroimag J

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Background:We studied the imaginary coherence (IC) of gamma frequency oscillations between brain regions of male schizophrenia patients during an auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG).Methods:Subjects were 10 right-handed male schizophrenia patients, evaluated by the positive and negative symptom scale (PANSS), and 10 healthy controls. Functional connectivity during the auditory oddball task was reconstructed in low (30-50 Hz) and high (50-100 Hz) gamma bands, and represented by imaginary coherence (IC) based on significant oscillatory power changes. We calculated correlations between PANSS scores and IC.Results:In the high gamma band, IC between left occipital and right prefrontal lobe areas during the time window 750-1000 ms from stimulus onset showed negative correlations with total negative scores, total positive scores, the sum of positive and negative scores in PANSS, conceptual disorganization, and social avoidance scores. In the low gamma band, IC between the same areas from 250-500 ms also showed a negative correlation with the conceptual disorganization score. In the same time window, IC between left occipital and right frontoparietal lobe areas in the low gamma band showed a positive correlation with hallucinatory behavior; IC between right temporal pole and left prefrontal lobe areas showed a positive correlation with delusion scores, although these ICs were decreased relative to controls.Conclusions:Functional disconnection of high and low gamma bands in auditory oddball task may play an important role in the auditory processing in schizophrenia patients.

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Section: Discussionmentioning

confidence: 99%

Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia

Fujimoto¹,

Okumura²,

Takeuchi³

et al. 2013

Open Neuroimag J

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“…It has been reported that increased latency does not appear to be related to medication [63], changes in P300 amplitude do not appear to be affected by antipsychotic medication [32], and attenuation of P300 in the frontal areas is greater in unmedicated than medicated patients and during the first episode of schizophrenia [64]. General slowing EEG frequencies has been reported as a consequence of neuroleptic medication, but differences slow wave activity in patients on and off neuroleptic might be the consequence of medication effect but also the consequence of symptom differences [65].…”

Section: Discussionmentioning

confidence: 99%

Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients

Fujimoto¹,

Okumura²,

Takeuchi³

et al. 2012

Open Neuroimag J

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Objective:We studied differences in the spatiotemporal dynamics of cortical oscillation across brain regions of patients with schizophrenia and normal subjects during the auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG).Methods:Ten right-handed male schizophrenia patients were studied. We used a newly developed adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction of MEG and EEG data, and obtained consecutive images in functional maps of event-related desynchronization (ERD) and synchronization (ERS) in theta, lower alpha (8–10 Hz), upper alpha (10–13 Hz), and beta bands.Results:Beta ERD power at 750–1000 ms in patients was significantly increased in large right upper temporal and parietal regions and small upper portions of bilateral dorsal frontal and dorsal-medial parietal regions. Theta ERS power in schizophrenic patients during the oddball task was significantly increased in the left temporal pole at 250–500 ms, and was significantly increased in dorsal, medial frontal, and anterior portions of the anterior cingulate cortex in both hemispheres, and the left portion of lateral temporal regions at 500–750 ms, compared to the control group (family-wise error correction p<0.05). Lower alpha ERS power was significantly decreased in the right occipital region at 500–750 ms and in the right midline parietal and bilateral occipital regions at 750–1000 ms. Upper alpha ERS power was significantly decreased in right midline parietal and left occipital regions at 750–1000 ms.Conclusions:ERD/ERS changes were noted in the left temporal pole and midline frontal and anterior cingulate cortex in theta ERS, occipital lobe in alpha ERS, and right temporal-frontal-parietal, midline frontal, and anterior cingulate cortex in beta ERD. These findings may reflect disturbances in interaction among active large neuronal groups and their communication with each other that may be related to abnormal cognitive and psychopathological function. Significance:Study of ERD and ERS by time-frequency analyses using MEG is useful to clarify data processing dysfunction in schizophrenia.

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“…As mentioned earlier, it is known that P300 has a symmetric distribution over left and right hemispheres of the scalp [28][29][30][31]. Incorporating this symmetric distribution and considering the spatial correlation of P300 in the system, motivates us to form a cooperative PF to enhance the accuracy of the tracking and estimation process.…”

Section: Cooperative Particle Filteringmentioning

confidence: 99%

“…We benefit from the well-known symmetric distribution of the P300 waveform over the left and right hemispheres of the brain [28][29][30][31], and introduce a novel cooperative coupled particle filtering approach that enables us to track the dynamic changes of the shape, amplitude, and latency of the P300 subcomponents over different trials. This cooperative approach incorporates the spatial correlation of the ERPs and benefits from their bilateral symmetry to overcome the uncertainty of the estimation and tracking processes.…”

Section: Introductionmentioning

confidence: 99%

Cooperative Particle Filtering for Tracking ERP Subcomponents from Multichannel EEG

Monajemi

Jarchi

Ong

et al. 2017

Entropy

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Abstract:In this study, we propose a novel method to investigate P300 variability over different trials. The method incorporates spatial correlation between EEG channels to form a cooperative coupled particle filtering method that tracks the P300 subcomponents, P3a and P3b, over trials. Using state space systems, the amplitude, latency, and width of each subcomponent are modeled as the main underlying parameters. With four electrodes, two coupled Rao-Blackwellised particle filter pairs are used to recursively estimate the system state over trials. A number of physiological constraints are also imposed to avoid generating invalid particles in the estimation process. Motivated by the bilateral symmetry of ERPs over the brain, the channels further share their estimates with their neighbors and combine the received information to obtain a more accurate and robust solution. The proposed algorithm is capable of estimating the P300 subcomponents in single trials and outperforms its non-cooperative counterpart.

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The distribution and latency of the auditory P300 in schizophrenia and depression

Cited by 28 publications

References 38 publications

Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia

Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia

Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients

Cooperative Particle Filtering for Tracking ERP Subcomponents from Multichannel EEG

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