The distribution of freely suspended particles at microfluidic bifurcations

Roberts, Brian W.; Olbricht, William L.

doi:10.1002/aic.10613

Cited by 49 publications

(33 citation statements)

References 16 publications

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“…Although a quantitative comparison with the available experimental data [15,16,21] is not possible due to the 2D assumption of the present simulations, the results in Figure 4 fairly reproduce the experimental trends. To show this, the inset of Figure 4a reports the experimental data taken from Ref.…”

Section: Resultssupporting

confidence: 77%

“…The way to visualize the simulation results shown in Figure 4a has been used in previous works dealing with particle separation processes in branched capillaries [13,15,16,21]. However, to better quantify the fractionation process, in what follows, we prefer to report the data as in Figure 4b.…”

Section: Resultsmentioning

confidence: 99%

“…Experimental and numerical studies have demonstrated that, when a suspension of rigid, non-Brownian particles under inertialess conditions flows through an asymmetric bifurcation, the partitioning of particles between the two downstream branches is different from the partitioning of the total suspension between these branches [13][14][15]. Volume excluded effects in the inlet channel, due to the existence of a zone near the channel wall unaccessible to the particles, and particle-wall hydrodynamic interactions are responsible for this different partitioning at bifurcations [16].…”

mentioning

confidence: 99%

“…Several studies have addressed the role of particle deformability [17][18][19][20], concentration [21][22][23][24] and shape of bifurcation [16,24] on the fluid-particle partitioning. Finally, the enrichment/depletion of particles in the two outlet streams has been proposed as an effective mechanism to design simple microfluidic devices for particle separation [16], fractionation [16] and filtering [15].…”

mentioning

confidence: 99%

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Separation of particles in non-Newtonian fluids flowing in T-shaped microchannels

D’Avino

Hulsen

Maffettone

2015

Adv. Model. and Simul. in Eng. Sci.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Separation of particles in non-Newtonian fluids flowing in T-shaped microchannels

D’Avino

Hulsen

Maffettone

2015

Adv. Model. and Simul. in Eng. Sci.

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“…Numerous papers available in the open literature demonstrate that rigid particles can be effectively sorted when a channel bifurcates into two branches, with particle distribution in the downstream branches different from the partitioning of the fluid stream [7][8][9]. The distribution of the particles in the downstream branches depends on the bifurcation geometry (especially the angle formed by the branches), the volume fraction of the suspended particles, and the flow rate ratio in the outlet branches.…”

mentioning

confidence: 99%

Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads

2017

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Document VersionAccepted manuscript including changes made at the peer-review stage Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. (2017). Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads. Physical Review E, 96(5), [053103]. DOI: 10.1103/PhysRevE.96.053103 Link to publication Citation for published version (APA): General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. We propose a square cross section microfluidic channel with an orthogonal side branch (asymmetric T-shaped bifurcation) for the separation of elastic capsules and soft beads suspended in a Newtonian liquid on the basis of their mechanical properties.The design is performed through 3D direct numerical simulations.When suspended objects start near the inflow channel centerline and the carrier fluid is equally partitioned between the two outflow branches, particle separation can be achieved based on their deformability, with the stiffer ones going 'straight' and the softer ones being deviated to the 'side' branch. The effects of the geometrical and physical parameters of the system on the phenomenon are investigated.Since cell deformability can be significantly modified by pathology, we give a proof of concept on the possibility of separating diseased cells from healthy ones, thus leading to illness diagnosis.

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Flow of concentrated suspension through oblique bifurcating channels

Reddy

Singh

2014

AIChE Journal

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Suspensions of solid particles in viscous fluid flowing through bifurcating channels are encountered in various industrial processes and biological applications. This work reports the detailed numerical simulations of shear-induced particle migration in oblique bifurcating channels. The effect of particle concentration, bifurcation angle, and flow rate on the partitioning of bulk flow and particles in the downstream branches is studied. It was observed that the particle distribution in the downstream branches does not follow the flow distribution due to shear-induced particle migration. The velocity and concentration profile for suspension flow were observed to be symmetric in the inlet branch but asymmetric in the daughter branches. The degree of asymmetry and bluntness of velocity profile was observed to depend on the bulk particle concentration and bifurcation angle. The reported results could be useful in the design of flow devices handling suspension transport in bifurcating channels.

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The distribution of freely suspended particles at microfluidic bifurcations

Cited by 49 publications

References 16 publications

Separation of particles in non-Newtonian fluids flowing in T-shaped microchannels

Separation of particles in non-Newtonian fluids flowing in T-shaped microchannels

Numerical design of a T-shaped microfluidic device for deformability-based separation of elastic capsules and soft beads

Flow of concentrated suspension through oblique bifurcating channels

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