The Distribution of Noradrenaline and Adrenaline in the Fallopian Tube of the Rabbit

Brundin, Jan

doi:10.1111/j.1748-1716.1964.tb03963.x

Cited by 13 publications

(5 citation statements)

References 13 publications

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“…The manner whereby this influence was achieved is not understood, but the events at mating could modify tubal physiology by at least 2 possible routes: 1) The voluminous seminal plasma could be exerting a specific effect on the smooth musculature of the isthmus [Einarsson and Wring, 1973;Hunter, 19841, perhaps acting further to reduce the already negligible patency of this portion of the duct before ovulation; 2) neuroendocrine events initiated at coitus via the autonomic nervous system could be inducing changes in the function of the isthmus. The rich adrenergic innervation of the isthmic circular muscle layers has received extensive comment [Brundin, 1964;Black, 1974;Hunter, 19771. Apart from proposing to examine the nature of this apparent coital influence on the physiology of the Fallopian tubes, its potential relevance to current procedures in infertility clinics is worth noting.…”

Section: Discussionmentioning

confidence: 99%

Capacitation potential of the fallopian tube: A study involving surgical insemination and the subsequent incidence of polyspermy

Hunter

Nichol

1988

Gamete Research

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In an attempt to demonstrate limitations in the capacitating potential of the Fallopian tube, ejaculated boar spermatozoa were introduced directly into the isthmus at varying intervals before ovulation. The incidence and degree of polyspermy subsequently observed were taken as indicators of the population of capacitated spermatozoa confronting the newly ovulated eggs: the more extensive the condition of polyspermy, the greater the number of capacitated spermatozoa presumed to have been available at the site of fertilization. Results are based on 673 eggs from 53 animals. When suspensions containing 2.21-3.87 x 10(8) sperm per ml were introduced 36-40 hours and 26-30 hours before ovulation, 85% and 61% respectively of the eggs were polyspermic, such eggs exhibiting mainly dispermy and trispermy. By contrast, when comparable sperm suspensions from the same boar were instilled 17-18 hours before ovulation, 70% of the eggs were polyspermic but the degree of polyspermy had increased dramatically: most eggs contained 40 or more sperm heads in the vitellus, invariably forming swollen chromatin aggregates rather than male pronuclei. Surgical insemination at times closer to ovulation significantly reduced the incidence and degree of polyspermy, reaching a low of 2% with insemination 1-2 hours before ovulation. These results therefore support the concept of a limited capacitation potential of the Fallopian tube. In a separate series of observations, mating animals shortly before surgical insemination with sperm suspensions from the same boar markedly reduced the incidence of polyspermy. This latter observation may be of clinical significance in procedures of laparoscopic or transcervical insemination into the tubes to alleviate human infertility. The manner whereby myosalpingeal physiology could be modified in response to coital stimulation is discussed.

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Section: Discussionmentioning

confidence: 99%

Capacitation potential of the fallopian tube: A study involving surgical insemination and the subsequent incidence of polyspermy

Hunter

Nichol

1988

Gamete Research

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“…By histochemical (Falck, 1962) and biochemical (Haggendal, 1963) methods for norepinephrine, the degree of adrenergic innervation has been shown to increase from the ovarian to the uterine end of the rabbit oviduct (Brundin, 1964c(Brundin, , 1965Brundin & Wirsen, 1964;Owman, Rosengren & Sjoberg, 1966). In the rabbit, the rich adrenergic innervation has been correlated to a sphincter¬ like activity (Brundin, 1964a(Brundin, , b, 1965.…”

Section: Introductionmentioning

confidence: 95%

The Effects of Adrenergic Drugs on Ovum Transport Through the Rabbit Oviduct

Polidoro¹,

Howe²,

Black³

1973

Reproduction

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The effect of adrenergic drugs on ovum transport through the oviduct was studied at 24, 36, 48, 60, 72 and 84 hr post coitum (p.c.) in 240 mature, female Dutch-belted rabbits.In untreated rabbits, ova were located in the area of the ampullaryisthmic junction at 24 hr p.c.; most ova entered the uterus between 72 and 84 hr p.c. Epinephrine increased (P<0\m=.\01) the rate of ovum transport at 60 and 72 hr p.c., and most of the ova were found in the uterus. Phenoxybenzamine (\g=a\-blocker) inhibited ovum transport at 48 hr p.c. (P<0\m=.\05), while propranolol (\g=b\-blocker) was ineffective in altering ovum transport in any of the time periods.Regulation of ovum transport through the rabbit oviduct appeared to be governed in part, by a neural-endocrine interrelationship; this relationship could be altered by adrenergic stimulants and blocking agents.

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“…The rabbit oviduct receives substantial adrenergic innervation, particularly in the region of the ampullary-isthmic j'unction and isthmus (Brundin, 1964a(Brundin, , 1965Owman, Rosengren & Sjoberg, 1966). It has been suggested that the isthmus acts as an adrenergically controlled sphincter which regulates the passage of ova from the ampulla to the uterus (Brundin, 1964b, c).…”

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confidence: 99%