The distribution of the MiIII (GP.Mur) phenotype among the population of Taiwan

Abstract

The MiIII (Gp.Mur) phenotype is rare among Caucasians but has a much higher incidence among some Oriental populations. In Taiwan the population is relatively heterogenous and, as expected, the incidence of the MiIII phenotype was found to vary markedly among the different ethnic groups. The highest frequencies of the MiIII phenotype were found among some of the indigenous groups, namely the Ami, Yami and Puyuma groups, being 88.4%, 34.3% and 21.2%, respectively, which are also the highest frequencies among any population group reported so far. Antibody screening cells and antibody identification panels containing the MiIII phenotype can obviously be obtained very easily from Ami blood donors and compatible blood for patients with anti-"Mia' can most easily be obtained from Chinese blood donors, except those living on the east coast.

BGMUT Database of Allelic Variants of Genes Encoding Human Blood Group Antigens

“…The diversity among the antigens is a result of sequence variations in genes that directly or indirectly affect expression or epitopic nature of the antigens on the surface of erythrocytes. For any blood group system, only one or a few common phenotypes predominate in the population, with a frequency distribution of variant phenotypes asymptotically approaching zero though exceptions have been documented [1]. However, the necessity of testing donated blood for compatibility for blood transfusion has led to the identification of even extremely rare variants of blood types.…”

MNS Blood Group System

“…In another study on Thais, molecular analysis on the 9% that were serologically Mi(a + ) showed that 88% had the GP.Mur gene and 11% the GP.Bun gene [321] . The frequency of GP.Mur reaches 88% in the Ami mountain people of Taiwan, but was not found in some other Taiwanese indigenous groups [220] . The frequency of GP.Mur reaches 88% in the Ami mountain people of Taiwan, but was not found in some other Taiwanese indigenous groups [220] .…”

“…About 10% of Thai blood donors were Mur + ; of these, 93% were Hop − (GP.Mur) and 7% were Hop + (GP.Bun) [219,297] (Table 3.9 ). GP.Mur has a frequency of around 6% and 7% in Hong Kong and Taiwan Chinese, respectively [220,322] . GP.Mur has a frequency of around 6% and 7% in Hong Kong and Taiwan Chinese, respectively [220,322] .…”

BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems

“…The use of transfusion being ubiquitous in the practice of medicine, populations worldwide are serologically tested and variant antigens and their genes, in contrast to many other variant genes are being documented in a large number of diverse populations. Although some variants occur rarely and, may only be observed in a single individual or family, others appear in unexpectedly large populations, such as the MiIII phenotype encoded by the MiIII GYPA gene, in Taiwan (incidence can be as high as 88% among Ami tribes) (2). For many alleles, the database also provides information on the geographic or ethnic origin of alleles and/or their associated serological phenotypes when such information was presented in the publications describing the alleles.…”