The Distribution of Tp53 Gene Polymorphisms in Chronic Lymphocytic Leukemia Patients, Sufferers of Chornobyl Nuclear Power Plant Accident

Abstract

Previous analyses in a cohort of Chornobyl cleanup workers revealed significantly increased radiation-related risk for all leukemia types, including chronic lymphocytic leukemia (CLL). Numerous investigations emphasized the significance of genetic susceptibility to the radiation carcinogenesis. The aim of the work was to study the distribution of TP53 single nucleotide polymorphisms (SNPs) in CLL patients exposed to ionizing radiation (IR) due to Chornobyl nuclear power plant accident and estimate their impact on disease development. Materials and Methods: The TP53 exonic and intronic SNPs were analyzed in 236 CLL patients by polymerase chain reaction and direct sequencing. The main group included 106 IR exposed CLL patients and the control group was composed of 130 IR non-exposed CLL patients. Results: Nineteen TP53 SNPs were found in the observed CLL cohort. No significant differences were found between the main and the control groups, but increased frequencies of T/T rs12947788 + G/G rs12951053 homozygotes and rs146340390 C/T variants were found among IR-exposed CLL patients compared with healthy Europeans (data from the 1000 Genomes Project). Rare nucleotide substitution rs146340390 (c.665C>T) was found only in the main group. These features were primarily typical for the most affected group of IR-exposed patients, namely, cleanup workers engaged in emergency works in the 2nd quarter of 1986. Conclusion: These preliminary findings don’t contradict the assumption on possible influence of IR on CLL development via the p53-dependent pathway. This article is a part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.

Haplotypes of single cancer driver genes and their local ancestry in a highly admixed long-lived population of Northeast Brazil

“…, 2018 ). GT (18.4%) -0.97 82.37 0.838 0.93-1.0 CT (2.4%) -0.97 82.37 0.838 0.93-1.0 GC (50.1%) rs7188750 rs4783689 -0.96 13.52 0.103 0.82-1.0 rs7188750 ( Beeghly-Fadiel et al , 2010 ); rs4783689 ( Jia et al , 2015 ; Geng et al , 2018 ) G T (27.5%) -0.96 13.52 0.103 0.82-1.0 AC (22.2%) -0.96 13.52 0.103 0.82-1.0 17p13 TP53 ATC (58.4%) rs12951053 rs2909430 rs1042522 1 3.56 0.035 0.58-1.0 rs12951053 ( Mechanic et al, 2007 ; Ru et al , 2015 ; Bilous et al. , 2016 ) rs2909430 ( Mechanic et al, 2007 ; Bilous et al , 2017 ) rs1042522 ( …”

“…Alleles of haplotypes that increased the risk of cancer in previous studies are highlighted in grey, whereas protective alleles are highlighted in grey and written in bold-type letters. (Hou et al, 2017;Wang et al, 2018;Song et al, 2019) rs3025040 (Jeon et al, 2014;Liu et al, 2017) rs10434 (Jeon et al, 2014;Zhu et al, 2015;Wang et al, 2018) CCA (29.1%) (Hoffmann et al, 2017) Increased PSA rs11568818 (Beeghly-Fadiel et al, 2009;Sharma et al, 2012;Wu et al, 2013;Wieczorek et al, 2014;Kesh et al, 2015;Horvat et al, 2017;Xie et al, 2016;Bialkowska et al, 2018) CC (43.6%) (Mechanic et al, 2007;Ru et al, 2015;Bilous et al, 2016) rs2909430 (Mechanic et al, 2007;Bilous et al, 2017) rs1042522…”

Molecular and <em>in silico</em> Study of TP53 Codon 72 Polymorphism (rs1042522) in a Population Exposed to High Background Radiation in Mamuju-West Sulawesi

“…TP53 is also highly polymorphic. Furthermore, one of the most widely-investigated single nucleotide polymorphisms (SNPs) in TP53 is the rs1042522 polymorphism in codon 72 on exon 4, which results in the translation of either a proline or an arginine residue [11]. The TP53 protein is a homotetramer composed of 393 amino acids.…”