The domestic cat antibody response to feline herpesvirus-1 increases with age

Munks, Michael W.; Montoya, Alana; Pywell, Cameron; Talmage, Garrick; Forssén, Anna; Campbell, Teresa L.; Dodge, Donald D.; Kappler, John W.; Marrack, Philippa

doi:10.1016/j.vetimm.2017.05.002

Cited by 11 publications

(9 citation statements)

References 23 publications

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“…The transmission of pathogens among animals is influenced by many factors such as geographical location, age, sample type, and breeding environment (Biek et al., 2006; Munks et al., 2017). Because no nasopharyngeal swabs were collected in Hailin and Shenyang, only the positive rate of blood samples was compared to analyze these factors.…”

Section: Discussionmentioning

confidence: 99%

“…The transmission of pathogens among animals is influenced by many factors such as geographical location, age, sample type, and breeding environment (Biek et al, 2006;Munks et al, 2017) The proportion of FHV-1 in nasopharyngeal swabs (10/33) was much higher than that in the blood (2/33), indicating that sample type may affect the positive rate. As the best detection tissue for FIV and FeLV is blood (Ramírez et al, 2016), these two viruses were not detected in nasopharyngeal swabs in this study.…”

Section: F I G U R Ementioning

confidence: 99%

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Prevalence of four viruses in captive Siberian tigers from Northeastern China

Huang

Guo

et al. 2022

Transbounding Emerging Dis

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Our study investigated the prevalence of feline herpesvirus-1 (FHV-1), feline calicivirus (FCV), feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) in captive Siberian tigers in Northeastern China. A total of 324 blood samples and 33 nasopharyngeal swab samples of Siberian tigers collected from 2019 to 2021 in three cities were investigated by nested PCR. The results showed that 28.1% (91/324) tigers were infected with at least one virus; the positive rates of FHV-1, FCV, and FIV were 17.3%, 13.6%, and 0.9%, respectively; and the coinfection prevalence was 13.2%.No FeLV-positive sample was detected. And we found that the blood is the best for FCV, FIV, and FeLV detection, but nasopharyngeal swabs for FHV-1. By comparing the gD genes, TK gene, and gI gene of FHV-1, the homology of the three FHV-1 positive strains in this study was found to be 91.5%-99.9% shared with tigers and domestic cats. Based on a comparison of the nucleic acid sequences of 13 FCV strains, we found that the homology of strain HB-1926 with the other strains in this study was only about 77.7%, but shared 99.3% and 98.6% homology with Urnaba strain in American cat and TG1 strain in Chinese tiger, respectively. However, the other 12 FCV strains shared 87.1%-87.5% homology compared with the Chinese domestic cats. Phylogenetic tree analysis showed that the HB-1926 strain was not in the same clade as other strains.The fragments gag-p26, pol-RT, and pol-RNAse of Siberian tiger FIV shared more than 99% homology than domestic cats FIV subtype A. This study demonstrated that captive Siberian tigers in Northeastern China were exposed to FHV-1, FCV, and FIV, and it is necessary to develop more effective vaccines and improve daily management measures.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Prevalence of four viruses in captive Siberian tigers from Northeastern China

Huang

Guo

et al. 2022

Transbounding Emerging Dis

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“…Neutered status was a significant variable also for FHV-1 seropositive results (P=0.0001) and the model fit in the univariate analysis was adequate (Hosmer-Lemeshow goodness-of-fit P>0.05), with neutered cats that were more likely to be seropositive (odds ratio 5.45, 95% CI 2.261-13.141) compared to intact cats. This is probably a bias due to the older age of the neutered cats (mostly adults and seniors) and to the lower immunogenicity of FHV-1, which requires a longer time for the development of a strong immune response (Munks et al, 2017).…”

Section: Gender and Reproductive Statusmentioning

confidence: 99%

“…Early signs of illness are depression, anorexia, drooling followed by sneezing, coughing, ocular and nasal discharge and severe conjunctivitis. In the environment the virus is labile (Afonso et al, 2016;Gaskell et al, 2012;Horzinek et al, 2013;ABCD, 2017b;Monne Rodriguez et al, 2017;Munks et al, 2017). FCV has a significant genetic variability responsible for different clinical patterns: oral ulcers, chronic stomatitis and respiratory symptoms.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of serum antibody titres against feline panleukopenia, herpesvirus and calicivirus infections in stray cats of Milan, Italy

Dall’Ara

Labriola

Sala

et al. 2019

Preventive Veterinary Medicine

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“…An association between age and presence of herpesvirus antibodies has been reported previously. 17,30 , 31 DiGangi et al found that cats aged ⩾6 months were more likely to have FHV-1 neutralising antibodies than cats aged <6 months. 17 In the present study, cats from breeders were also more likely to have antibodies and this is also most likely due to a higher risk of infection and reinfection in such households.…”

Section: Discussionmentioning

confidence: 99%

Antibody response to feline herpesvirus-1 vaccination in healthy adult cats

Bergmann¹,

Speck

Rieger³

et al. 2019

Journal of Feline Medicine and Surgery

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Objectives Vaccination against feline herpesvirus-1 (FHV-1) is recommended for all cats. However, it is unknown how adult healthy cats with different pre-vaccination antibodies respond to FHV-1 vaccination in the field. The aim of the study was to determine the prevalence of neutralising antibodies against FHV-1 in healthy adult cats and the response to FHV-1 vaccination within 28 days of vaccination. Methods One hundred and ten cats (⩾1 year of age) that had not received a vaccination within the past 12 months were vaccinated with a combined FHV-1 vaccine. Antibodies against FHV-1 were determined before vaccination (day 0), on day 7 and day 28 by serum neutralisation test. Uni- and multivariate statistical analyses were used to determine factors associated with the presence of pre-vaccination antibodies and response to vaccination. Results Pre-vaccination neutralising antibody titres (⩾10) were present in 40.9% of cats (45/110; 95% confidence interval [CI] 32.2–50.3); titres were generally low (range 10–640). Antibody response to vaccination (⩾four-fold titre increase) was observed in 8.3% (9/109; 95% CI 4.2–15.1). Cats ⩾2 years of age were more likely to have pre-vaccination neutralising antibodies than cats aged between 1 and 2 years (odds ratio [OR] 24.619; P = 0.005). Cats from breeders were more likely to have pre-vaccination neutralising antibodies than privately owned cats (OR 7.070; P = 0.007). Domestic shorthair cats were more likely to have an at least four-fold titre increase vs purebred cats (OR 11.22; P = 0.027). Conclusions and relevance Many cats have no detectable neutralising antibodies against FHV-1 despite previous vaccinations and fail to develop a ⩾four-fold titre increase after vaccination. This is likely because older cats and cats with a higher FHV-1 exposure risk are more likely to get infected with FHV-1 and thus to have FHV-1 neutralizing antibodies. Purebred cats more often fail to develop a ⩾four-fold titre increase after vaccination.

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The domestic cat antibody response to feline herpesvirus-1 increases with age

Cited by 11 publications

References 23 publications

Prevalence of four viruses in captive Siberian tigers from Northeastern China

Prevalence of four viruses in captive Siberian tigers from Northeastern China

Prevalence of serum antibody titres against feline panleukopenia, herpesvirus and calicivirus infections in stray cats of Milan, Italy

Antibody response to feline herpesvirus-1 vaccination in healthy adult cats

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