The effect of 25% Mauli banana stem extract gel to increase the epithel thickness of wound healing process in oral mucosa

Maharani, Laillyza Apriasari; Ariska, Endariantari

doi:10.20473/j.djmkg.v48.i3.p150-153

Cited by 13 publications

(12 citation statements)

References 5 publications

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“…Due to its aloevera extract content, aloclair can accelerate wound healing through stimulation of and increase in anti-inflammatory cell activity which enhances the reepithelization process. 13 Acyclovir intake was consistently managed by the patient during a period of two weeks. An antiviral drug was administered to resolve the herpes infection resulting from the immunocompromised condition of the patient who was eventually declared to have been cured of herpes labialis.…”

Section: Discussionmentioning

confidence: 99%

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

Apriasari

2019

Dent. J.

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Background: As reported in several studies, prolonged or uncontrolled cases of diabetes mellitus (DM) may induce a more extreme inflammatory response. Mucosal lesions can be observed in patients who present this systemic condition. Purpose: The purpose of this study was to elaborate the management of herpes labialis, oral thrush and angular cheilitis as oral manifestations of diabetes. Case: A 49-year-old male complained of having experienced painful lip ulceration for the preceding seven days. The anamnesis of the patient revealed that, prior to lip ulceration, he had experienced high fever and malaise in addition to frequent urination at night and a tingling sensation in the toes and fingertips on waking. Case management: The patient was referred to undergo blood count, fasting blood glucose and oral glucose tolerance tests. The blood test result confirmed the patient to be suffering from DM and anemia. The immunocompromised condition of the patient prompted the occurrence of herpes labialis, oral thrush and angular cheilitis. Conclusion: Multidisciplinary treatment for herpes labialis resulting in oral candidiasis in DM patients is indispensable. Concurrent infection with HSV and candidiasis necessitates a more prolonged healing process. Consequently, it is a essential to treat the hyperglycemia which induces an immunocompromised state in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

Apriasari

2019

Dent. J.

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“…M3-50 : Amount of fibroblasts cells in the Treatment group with 50% Mauli banana stem extract on day 3. at a concentration of 25% can accelerate the healing process in incised wounds on the oral mucosa of rats by increasing the number of macrophages on day 3, and subsequently decreasing them on the fifth day. 13 Macrophages play an important role in the wound healing process since they produce growth factors as well as trigger angiogenesis and fibro genesis. The excreted macrophages can even phagocytize bacteria and clean out tissue debris.…”

Section: Note: C3mentioning

confidence: 99%

FGF-2 expression and the amount of fibroblast in the incised wounds of Rattus norvegicus rats induced with Mauli banana (Musa acuminata) stem extract

Aspriyanto¹,

Nirwana²,

Budi³

2018

Dent. J. (Maj. Ked. Gigi)

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Background: Traditional wound treatment using herbal medicine is thought to maintain the health of families and society in general economically, effectively, and efficiently without inducing side effects. One genus of plant that can be used as a traditional medicine is the Mauli banana, indigenous to South Borneo. Mauli banana stem contains bioactive compounds, most of which are tannins along with ascorbic acid, saponin, β-carotene, flavonoids, lycopene, alkaloids, and flavonoids. Tanin has antibacterial and antioxidant effects at low concentrations, as wells as antifungal ones at high concentrations. Purpose: This study aimed to analyze the effects of Mauli banana stem extract at concentrations of 25%, 37.5%, and 50% on the quality of incised wound healing in male Rattus norvegicus rats by assessing FGF-2 expression and fibroblast concentration on days 3 and 7. Methods: This research represented an experimental laboratory-based investigation involving 32 rats of the Rattus norvegicus strain aged 2-2.5 months old. Sampling was performed using a simple random sampling technique since the research population was considered homogeneous and divided into 8 treatment groups (C3, M3-25, M3-37.5, M3-50, C7, M7-25, M7-37.5, M7-50). The rats in each group were anesthetized before their back was incised with length and width of 15x15mm with a depth of 2mm. Gel hydroxy propyl cellulose medium (HPMC) was applied to the incised wound of each rat in the control group, while stem Mauli banana extract was applied to that of each rat in the treatment groups three times a day at an interval of 6-8 hours. On day 3, four rats from each group were sacrificed, while, in the remaining groups, the same procedure was performed until day 7, at which point they (8 groups) were sacrificed for HE examination in order to assess the amount of fibroblast and for IHC examination to examine FGF-2 expression. Data regarding FGF-2 expression and the amount of fibroblast were analysed by means of One-way Anova and HSD. Results: The results showed that the Mauli banana stem extract could significantly improve the expression of FGF-2 and the amount of fibroblast cells compared to C3 and C7 groups. The highest increase in FGF-2 expression and fibroblast amount were found in all groups on days 3 and 7 treated with the Mauli banana stem extract at a concentration of 50%. Conclusion: There was an increase of FGF-2 expression and the amount of fibroblast cells in the incision wound healing process that induced with Mauli banana stem extract.

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“…3 MASE of 25% concentration exhibited strong antibacterial and antifungal properties against Streptococcus mutants and Candida albicans. 4 The antioxidant property was achieved through the binding of MASE's bioactive compounds with ferrous iron, hydrogen peroxide, and hydroxyl.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Moreover, MASE gel of 37.5% concentration can induce epithelium and fibroblast proliferation, as well as vascular endothelial growth factor in mucosal wounds of Rattus norvegicus, thus accelerating the wound-healing process. 4,5 The most abundant bioactive compound in MASE is tannin, which contains polyphenols. 2,3 The polyphenol showed anti-inflammatory effects through the inhibitory mechanism of tumor necrosis factor α (TNF-α) and nuclear factor kappa β (NF-κB) signal.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Musa acuminata Stem

et al. 2020

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Objective This study was designed to assess the anti-inflammatory effect of Musa acuminata through the expression of tumor necrosis factor-α (TNF-α) and nuclear factor kappa β (NF-κB) after 3 days of application of Musa acuminata stem extract (MASE) gel on oral mucosal wound. Materials and Methods An experimental study with post-test only control group design was conducted. Twenty male Rattus norvegicus (Wistar) were injured on their left buccal mucosa and treated three times a day with MASE gel of varying concentrations: 0% (as control), MASE 25%, MASE 37.5%, and MASE 50%. On day 3, a biopsy was performed on each mucosal wound for later immunohistochemical analysis for the expressions of TNF-α and NF-κB. Results The highest expression of TNF-α was observed in the control group (13.20 ± 1.79), while the lowest was in the treatment group using 50% MASE (6.40 ± 1.14). Meanwhile the comparison between treatment groups did not highlight any significant difference (p > 0.05). The highest expression of NF-κB was observed in the control group (13.20 ± 1.30), whereas the lowest was in the treatment group using MASE 50% (6.40 ± 1.14). NF-κB was significantly lower in the treatment group using MASE 50% when compared with other treatment groups (p < 0.05). Conclusion Application of MASE on mucosal wound reduces the expression of TNF-α and NF-κB at all concentrations. The anti-inflammatory effect of MASE 50% was the strongest one.

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The effect of 25% Mauli banana stem extract gel to increase the epithel thickness of wound healing process in oral mucosa

Cited by 13 publications

References 5 publications

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

FGF-2 expression and the amount of fibroblast in the incised wounds of Rattus norvegicus rats induced with Mauli banana (Musa acuminata) stem extract

Anti-Inflammatory Effect of Musa acuminata Stem

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