The effect of a mouthrinse containing chlorhexidine and fluoride on plaque and gingival bleeding

Abstract

The aim of this study was to test the effect of a rinse with 0.05% sodium fluoride and 0.05% chlorhexidine on plaque and gingival inflammation compared with a placebo without these agents. In a double-blind study, 47 adults with > 20 teeth and a CPITN score > 1 but < 4 were randomised into test and control groups. After baseline assessments for plaque, bleeding and stain, teeth were professionally cleaned. Subjects were asked to rinse for 30 s with 10 ml of the respective test or placebo rinse after normal oral hygiene for 8 weeks. 39 subjects completed the study. There was no significant difference in the 2 groups at baseline with respect to either plaque or bleeding scores. After scaling and 8 weeks use of the test rinse, there were significant reductions (p < 0.001) in both plaque and bleeding. The control group showed no significant reduction in plaque scores after 8 weeks, but a significant (p < 0.05) reduction in bleeding. However, this reduction was significantly greater (p < 0.001) in the test group than in the control. The test group had a significantly greater (p < 0.05) stain score than the control at baseline. After scaling and rinsing for 8 weeks, stain scores were lower for both groups compared to baseline but reached significance (p < 0.05) only for the control group. It is concluded that, as an adjunct to normal oral hygiene, the chlorhexidine/fluoride rinse had a significant inhibitory effect on plaque and bleeding but its effect on staining is uncertain.

Oral health of children undergoing allogeneic bone marrow transplantation

“…26 An important part of the mouthcare regimen for immunosuppressed patients is rinsing with 0.2% chlorhexidine, which if used effectively, reduces plaque accumulation (and bacterial loading). 27,28 This has been reported by several groups of investigators, [29][30][31] as has a reduction in the frequency of isolation of the viridans streptococci. 30,32 Most of the children in the present study were unable to use the chlorhexidine effectively for two main reasons.…”

Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review

“…). Although the plaque inhibition of low CHX concentrations is dose‐dependent, and low‐concentration rinses may be less effective, some studies have demonstrated efficacy of low‐CHX rinses (0.06%) in reducing plaque (Joyston‐Bechal & Hernaman , Hoffmann et al. , Claydon et al.…”

“…Concentrations of 0.12% CHX appear to be as effective as 0.2% if the volume of the rinse is increased from 10 to 15 ml, each of which provides a dose of 18 mg (Keijser et al 2003, Van Strydonck et al 2005. Although the plaque inhibition of low CHX concentrations is dosedependent, and low-concentration rinses may be less effective, some studies have demonstrated efficacy of low-CHX rinses (0.06%) in reducing plaque (Joyston-Bechal & Hernaman 1993, Hoffmann et al 2001, Claydon et al 2002, Zimmer et al 2006, Duss et al 2010. The efficacy of low CHX concentrations on the reduction on gingival inflammation however remains unclear.…”

The effect of toothpaste on the propensity of chlorhexidine and cetyl pyridinium chloride to produce staining in vitro: a possible predictor of inactivation

“…Solutions of 0.2% CHX ‡, 0.05% CHX and 0.05% CPC were used. A concentration of 0.05% CPC was chosen as this is the most common concentration of CPC found in over‐the‐counter mouthwash preparations and has been a concentration used for some CHX mouthwashes ( Jenkins et al 1993, Joyston Bechal & Hernaman 1993). The 0.05% solution of CHX was prepared from a 20% aqueous solution † and distilled water.…”