The Effect of a New Anticholinergic Agent, Oxyphencyclimine Hydrochloride, on Gastric Secretion

Dw, Piper; Fm, Elliott; As, Sietsma; Aw, Pryor

doi:10.5694/j.1326-5377.1960.tb105342.x

Cited by 18 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If one surveys, however, the recorded work on the effect of anticholinergic drugs on hypoglycaemic stimulated secretion, it is found that many workers have found that the acid output is unaffected (Bayer and Bradford, 1952;Bayer, Plummer, and Bradford, 1952;Levin, Kirsner, and Palmer, 1952;Winkelstein, 1952;Roback and Beal, 1953;Weisiger, Burke, and Plummer, 1954;McKenna, Smith, and Wyse, 1954;Kasich, Boleman, and Rafsky, 1956;Bachrach, 1958). Others, nevertheless, have observed an inhibitory effect (Lieber, 1956;Plummer, Burke, and Bradford, 1951;Rock and Rohrer, 1958) and our own observations support these findings (Piper, Elliott, Sietsma, and Pryor, 1960). The failure to observe a drop after anticholinergic drugs by some workers appears to have been due to inadequate dosage of the drug and the inability to make repeated observations on the same patient.…”

Section: Discussionsupporting

confidence: 66%

“…A subsequent study of its effect on saliva flow and gastric secretion by Piper et al (1960) confirmed its prolonged action in humans. The present investigation showed that it has a more selective action on the stomach than atropine but that it is not as selective two and a half hours after its administration as propantheline.…”

Section: Discussionmentioning

confidence: 71%

“…When the two preparations are compared as in Table V it is seen that 30 mg. of propantheline had a more marked effect on gastric secretion than 10 mg. of oxyphencyclimine, whereas the latter had a more marked effect on saliva flow than 30 mg. of propantheline; neither of these differences were significant at the 5 % level, however. It must be realized in such a comparison as this that we are-comparing two drugs 0-2<P<0-1 79 whose length of action is dissimilar (Piper, Elliott, Sietsma, and Pryor, 1960). It was noted that when two 15-minute specimens were taken, two and a half to three hours after propantheline, the second was usually greater than the first, whereas after oxyphencyclimine both specimens tended to be equal.…”

Section: Resultsmentioning

confidence: 99%

“…The present investigation showed that it has a more selective action on the stomach than atropine but that it is not as selective two and a half hours after its administration as propantheline. Its chief advantage appears to be its prolonged action which is almost twice as long as that of propantheline (Piper et al, 1960); thereby night secretion can be controlled and, with three doses during the day, a constant inhibitory effect can be obtained. However, if the length of action is of no importance, it appears that propantheline is superior to oxyphencyclimine because of its more selective action on the stomach.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A comparison of a series of newer anticholinergic agents with atropine as regards their effect on saliva flow and gastric secretion in man

Piper¹,

Stiel²

1962

Gut

Self Cite

View full text Add to dashboard Cite

SYNOPSISThe effect of anticholinergic agents-atropine, propantheline, oxyphencyclimine, and propionyl atropine methyl nitrate-on saliva flow and on hypoglycaemic stimulated gastric secretion has been studied. The acid secretion of the nervous phase of gastric secretion was inhibited by anticholinergic drugs. They influenced gastric secretion to a greater extent than saliva flow.Both propantheline and oxyphencyclimine have a selective action on the stomach superior to atropine. Propionyl atropine methyl nitrate appears to have only weak anticholinergic activity in the dose recommended and is not superior to atropine.Anticholinergic drugs are widely used in the treatment of peptic ulcer and with this aim new preparations are constantly being produced. One of the advantages over atropine claimed for the newer preparations is that they produce fewer side-effects, which implies that they have a selective action on the stomach. Apart from one French study (Lieber, 1956) that showed that the more recently developed preparations were inferior to atropine in this respect, there is no work in man, supported by the quantitative determination of their effect on gastric secretion and of their side-effects, comparing atropine with the newer anticholinergic agents.Because of the importance of whether or not the newer drugs have a selective action on the stomach, the present study was undertaken. Atropine and three new preparations (propantheline, oxyphencyclimine, and propionyl atropine methyl nitrate) were compared as regards their effect on saliva flow and on hypoglycaemic stimulated gastric secretion. METHODFor several reasons it was not possible to determine both responses in the same group of patients. Consequently one group of volunteers was studied as regards saliva flow and a second group as regards gastric secretion; the results were then analysed statistically.Saliva flow was stimulated by chewing. Gum devoid of the outer flavoured coat was used; the gum was chewed for 10 minutes and the volume of saliva secreted measured.Three control readings were taken and subsequently readings at hourly intervals after the administration of the drug until saliva flow returned to normal. Side-effects, particularly the presence of a dry mouth, blurred vision, or difficulty in micturition were noted. The volunteers used in this study were members of the resident medical staff; seven such studies were made.The effect on gastric secretion was determined using hypoglycaemic stimulated secretion. For this, patients having insulin coma therapy for psychiatric reasons were used. After fasting, the drug was given between 6.30 a.m. and 6.45 a.m. followed by a large dose of insulin (the dosage ranged between 200 and 1,600 units). The patient went into coma two to two and a half hours after the administration of insulin and spent one hour in coma. Coma was considered to be present when the patient no longer responded to painful stimuli and extensor plantar responses were present. It had previously been determined that under these conditions c...

show abstract

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A comparison of a series of newer anticholinergic agents with atropine as regards their effect on saliva flow and gastric secretion in man

Piper¹,

Stiel²

1962

Gut

Self Cite

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that despite the fact that anticholinergic drugs will inhibit the output of acid, the concentration of acid shows relatively little fall (Keeton, Luckhardt, and Koch, 1920;Polland, 1930;Gray, 1943;Notkin, Forse, and Webster, 1953;Piper, Elliott, Sietsma, and Pryor, 1960). It is possible that the drop in acid secretion could be accompanied by a fall in the output of the alkaline secretion, or the latter could remain relatively un-changed.…”

Section: Discussionmentioning

confidence: 99%

The effect of anticholinergic drugs on the electrolyte content of gastric juice

Piper¹,

Stiel²

1961

Gut

Self Cite

View full text Add to dashboard Cite

SYNOPSIS Gastric secretion was stimulated by insulin hypoglycaemia and the effect of increasing doses of anticholinergic drugs on the volume, acid, and electrolyte content of gastric juice was studied. The sodium and potassium output was depressed to a far less extent than the acid output and the drop in volume of secretion and acid output after anticholinergic drugs is almost entirely due to decreased acid secretion. With increasing anticholinergic suppression of the volume of secretion, there is a marked fall in potassium output and a lesser fall in sodium output. The potassium concentration showed a slight fall and there was a rise in sodium concentration.The effect of various anticholinergic drugs on gastric acid secretion has been studied by many workers. The acid concentration and output so investigated represents the amount of parietal secretion remaining after dilution and partial neutralization by the alkaline component, chiefly mucus and sodium and potassium chloride and bicarbonate. Hence it is of some interest to know the effect of anticholinergic agents on the electrolyte content of gastric juice; as far as can be ascertained, this has not been previously studied. METHODSThe patients studied were psychiatric patients having insulin coma therapy. All were free of gastrointestinal disease. Their repeated treatment enabled many observations to be made on the same patient. A Cleland tube was passed when the patient became comatose, coma being considered to be present when patients no longer responded to painful stimuli and bilateral extensor plantar responses were present. Continuous suction was applied for about 15 minutes to remove the gastric residue and two 15-minute specimens were collected during the last 30 to 45 minutes spent in coma. Blood sugar estimations were done initially but were discontinued when it was found reproducible control results were obtained under the above conditions, whatever the actual blood sugar level found. Patients were included in this study only if the control secretory rates were high (>3 ml./min.) and the specimens were not bile-stained.The series of anticholinergic drugs included atropine, propantheline, oxyphencyclimine, and propionyl atropine methyl nitrate. These were administered orally two to two and a half hours before the onset of coma.From the design of the experiments, maximal hypoglycaemic stimulation was considered to be present because the patients were comatose from hypoglycaemia during the period gastric secretion was collected. That this is a constant base line from which to assess changes is shown by the fact, discussed later in this article, that in 10 control observations on three patients the standard deviation was only 3-7% of the mean secretion under these circumstances. A greater error than this could be expected, however, when the volume of secretion was small. It is appreciated that the time of maximum action of the drugs administered varied and would not necessarily coincide with the time of collection of gastric juice. It is seen in Table I...

show abstract

The adsorption of pepsin

Piper

Fenton

1961

Digest Dis Sci

View full text Add to dashboard Cite

The Effect of a New Anticholinergic Agent, Oxyphencyclimine Hydrochloride, on Gastric Secretion

Cited by 18 publications

References 18 publications

A comparison of a series of newer anticholinergic agents with atropine as regards their effect on saliva flow and gastric secretion in man

A comparison of a series of newer anticholinergic agents with atropine as regards their effect on saliva flow and gastric secretion in man

The effect of anticholinergic drugs on the electrolyte content of gastric juice

The adsorption of pepsin

Contact Info

Product

Resources

About