The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection

Yaylacı, Selçuk; Dheir, Hamad; İşsever, Kubilay; Genç, Ahmed Bilal; Şenocak, Didar; Kocayiğit, Havva; Güçlü, Ertuğrul; Süner, Kezban Özmen; Ekerbiçer, Hasan Çetin; Köroğlu, Mehmet

doi:10.1590/1806-9282.66.s2.86

Cited by 24 publications

(30 citation statements)

References 7 publications

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“…In literature, there are studies investigating the effect of blood groups on clinical prognosis of patients. In the study by Juyi et al, the rate of hospitalization was higher in patients with A blood groups in SARS-CoV-2infection and in another study, the rate of Rh positivity was reported to be higher in patients hospitalized in the intensive care unit (ICU) (20,21). Our data are similar to findings in these studies.…”

Section: Resultssupporting

confidence: 90%

Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Aslaner¹,

Gökçek

Benli

et al. 2021

Medical Records

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Aim: This study aimed to investigate the effect of blood groups on the risk and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the infected/source cases and contact individuals. Material and Method: This study was designed as a descriptive and retrospective study. The individuals who were in contact with the SARS-CoV-2main/source cases and followed at home were included in the study.The distribution of the participants according to their blood groups was assessed. Patients were divided into three groups as group 1 including source/main cases, group 2 including SARS-CoV-2contacts who were living in the same house with the source case and followed up, and group 3 including contacts who were followed up in the same house but did not develop SARS-CoV-2 during the follow-up. Results: While the rate of Non-O blood group was the highest (n=365, 39.4%) in group 2the rate of O blood group was the highest (n=190, 42.8%) in group 3 (p:0.028). While the rate of Rh positive blood group was high in group 1 that of Rh negative blood group was higher in group 3 (p:0.000). For other variables, the presence of a chronic disease was more in group 1 (p:0.000). Rh (+) blood group (OR:0.464, p:0.010, %95 Cl: 0.306 ~ 0.703) was among the factors affecting the development of the infection. Conclusion:Patients infected with SARS-CoV-2 mostly had A, Non-O blood group and Rh positivity. Having Rh (+) blood group may have increased the rate of infection development in high-risk household contacts. After patients in this blood group were detected as contacts a closer follow-up may be necessary to decrease morbidity.

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Section: Resultssupporting

confidence: 90%

Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Aslaner¹,

Gökçek

Benli

et al. 2021

Medical Records

View full text Add to dashboard Cite

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“…Another similarity between adult and pediatric infected patients admitted to PICU is the high percentage of blood group A as previously reported by Yaylac et al; a similar trend was observed in our study. 35 Additionally, comorbidities affected the PICU admission and length of stay significantly. In our cohort, co-morbid conditions were recorded in 26 (60.5%) patients, with malignancy being the commonest (20.9%).…”

Section: Discussionmentioning

confidence: 99%

Changes in Hematological, Clinical and Laboratory Parameters for Children with COVID-19: Single-Center Experience

Saleh¹,

Al-Kofide²,

Alshammari³

et al. 2021

JBM

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Background: COVID-19 wreaked havoc on the healthcare system, with more than 36 million cases reported globally. Although the pediatric population makes up a lesser proportion of total COVID-19 patients than adults, the clinical status, age and comorbidities warrant identifying possible prognostic factors associated with disease severity in this group. The current study aimed to explore the incidence of thrombosis, overall outcome, and different hematological and coagulation markers in children with COVID-19. Methods: This is a single-center prospective study of 43 patients (age < 14 years) with confirmed COVID-19 diagnosis recruited from April to August 2020. Data for clinical presentation were collected and analyzed. The samples were tested for different hematological and coagulation markers. Results: Twenty-nine (67.4%) were symptomatic at presentation, with fever being the most common symptom (n = 23, 53.5%), followed by respiratory (n = 5, 11.6%) and gastrointestinal symptoms (n = 3, 7%). Co-morbid conditions were recorded in 26 (60.5%) patients, with malignancy being the commonest (n = 9, 20.9%). In this cohort of patients with age <14 years, hypertension, respiratory symptoms and ABO group-A were significantly associated with pediatric intensive care unit (PICU) admission during the course of treatment. Patients with elevated FVIII and fibrinogen levels at presentation were more likely to have an extended length of hospital stay (LOS) (P-value =0.036 and 0.032 respectively). No thrombotic event was observed in our cohort. D-dimer values were higher (above 0.5 µg/mL) in 24 (55.8%) patients at admission. We found an association between high D-dimer and PICU admission and LOS. Conclusion: Although we did not observe thrombosis in our cohort, serial measurements of D-dimer and elevated FVIII bear a prognostic value in predicting the need for critical care in children with COVID-19. Further studies with larger sample size can aid in the establishment of prognostic factors for the pediatric COVID-19 population.

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“…In various studies, it has been shown that in addition to blood groups' role in being infected with SARS-CoV-2, they may also affect the outcome of the illnesses. In their study Yaylaci et al [21] defined that ICU admission was higher in rate with the Rh (+) blood group (p=0.011), but no meaningful association was found between mortality and blood groups or Rh factors (p>0.05). In another study with 14112 participants, Zietz and Tatonetti [18] (2020) showed that the risk of intubation was significantly reduced in blood Groups A and marginally increased in blood Groups AB and B.…”

Section: Discussionmentioning

confidence: 91%

Association of blood groups on the risk of COVID 19 infection, morbidity and mortality

Sertbaş¹

2021

North Clin Istanbul

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T he novel coronavirus-19 disease due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was first reported in Wuhan, China, in December 2019 [1]. Since then, it has spread throughout the World with significant morbidity and mortality. In March 2020, the World Health Organization (WHO) reported COVID-19 as a pandemic and, over time, reported 110749023 confirmed cases of infection and 2455131 deaths until February 22, 2021 [2]. Due to the high morbidity and mortality associated withABSTRACT OBJECTIVE: We aimed to compare the effects of blood groups and Rh factor on the development of coronavirus-19 disease (COVID-19) with all aspects such as clinical course, inflammatory parameters, and organ-specific biochemical parameters with a significant number of patients.METHODS: This multicenter study was carried out retrospectively on 3551 patients hospitalized with the diagnosis of COVID-19 and whose blood groups were recorded during the time of hospitalization. As control groups, 22133 individuals' medical data who were admitted to the blood bank affiliated with our hospitals during the last year was used. The differences between the blood groups and clinical characteristics were analyzed. RESULTS:Of the 3551 patients, A Rh (+) blood group was found to be in a higher ratio in the case group than controls, with increased risk to be infected (case: 41.3% vs. control: 38.8%), (OR 1.113; 95% CI: 1.036-1.197; p=0.003). Meanwhile O Rh (+) blood group ratios were significantly lower in the case group than in the control group (case: 26% vs. control: 28.3%) (OR 0.862; 95% CI: 0.823-0.966; p=0.005). There was no significant difference between blood groups in terms of admission to the intensive care units and mortality, it was observed that patients with AB Rh (+) blood group have a greater risk for intubation than others (OR: 1.467; 95% CI: 1.040-2.071; p=0.028). CONCLUSION:We demonstrated that people with blood group A Rh (+) more susceptible to COVID-19, whereas blood group 0 Rh (+) have a protective effect against the infection. Once a person has been infected with severe acute respiratory syndrome coronavirus 2, we should be mindful that patients with blood group AB Rh (+) would be prone to intubation more than other blood groups.

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The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection

Cited by 24 publications

References 7 publications

Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Kan Gruplarının SARS-CoV-2 Enfeksiyonu ve Prognozu Üzerine Etkisi

Changes in Hematological, Clinical and Laboratory Parameters for Children with COVID-19: Single-Center Experience

Association of blood groups on the risk of COVID 19 infection, morbidity and mortality

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