The Effect of Activated Ergosterol and of Parathyroid Hormone on Gastric Secretion in the Dog

Babkin, B. P.; Komarov, O.S.; Komarov, S. A.

doi:10.1210/endo-26-4-703

Cited by 30 publications

(5 citation statements)

References 2 publications

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“…An apparently similar condition had been reported and illustrated with photographs by Hogan and Johnson ( 1). The condition has also been reported by several other workers (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Other verbal or in- --formal reports have come to us indicating a rather widespread occurrence of the condition in recent years.…”

Section: Time In Seoonossupporting

confidence: 80%

Effect of Pepsin Inhibitors on Milk Clotting Activity of Crystalline Pepsin.

Marini

Levey

1955

Experimental Biology and Medicine

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Section: Time In Seoonossupporting

confidence: 80%

Effect of Pepsin Inhibitors on Milk Clotting Activity of Crystalline Pepsin.

Marini

Levey

1955

Experimental Biology and Medicine

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“…This inhibitory effect of injecting calcium too rapidly may explain the discrepancy. Whereas most studies in man show that parenteral calcium leads to an increase in gastric secretion, in pigeons and various canine preparations, parenteral calcium has been found to inhibit gastric secretion (Ward et al, 1964;Cowgill and Rakieten, 1930;Babkin, Komarov, and Komarov, 1940;Grant, 1941;Mahfouz and Koskowski, 1959). However, in addition to possible species differences, the methods used in these studies have varied and are not strictly comparable with those used here.…”

Section: Effect Of Vagotomy and Cholecystectomy On The Gastric Secretmentioning

confidence: 99%

Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

Smallwood¹

1967

Gut

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“…Injections of calciferol, the effect of which on the serum calcium is slower and more prolonged, have provided conflicting results in man but appear to increase the secretion of acid and possibly of pepsin in the dog. Experimental reduction of the serum calcium by induction of rickets in rats is associated with gastric hyposecretion and therapy with vitamin D restores secretion to normal (Herting and Steenbock, 1955 Schiffrin (1942) (1961) 0 Schiffrin (1942) Allen and Elliott (1961) Babkin et al (1940), Schiffrin (1942), Neely and Goldman (1962) + Babkin et al (1940), Schiffrin (1942), Neely and Goldman (1962) Neely and Goldman (1962) Allen and Elliott (1961) Allen and Elliott (1961) Acid Pepsin -= depression 0 = no effect between 5 and 10 mg. per 100 ml. (Gray and Adkison, 1941).…”

mentioning

confidence: 99%

“…Majno, 1953), but are not caused by small doses (Babkin, Komarov, and Komarov, 1940;McJunkin, Tweedy, and Breuhaus, 1932). Hyperplasia ofthe chief cells (which secrete pepsin) has been observed after injections of parathormone and of vitamin D in rabbits and rats (Lewinter and Spiro, 1960) and hyperplasia of all the glandular elements (associated with hypersecretion of acid and of pepsin) has been reported after the administration of vitamin D in a dog (Neely and Goldman, 1962).…”

mentioning

confidence: 99%

The parathyroids, calcium and gastric secretion in man and the dog

Ward¹,

Adesola²,

Welbourn³

1964

Gut

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EDITORIAL SYNOPSIS The possible relationship between hyperparathyroidism and peptic ulcer has stimulated renewed interest in the relationship between calcium and gastric secretion. This study shows that in patients with primary hyperparathyroidism the basal secretion of acid was raised but the augmented histamine secretion was essentially normal. The basal secretion was lowered by parathyroidectomy. Studies in dogs shows a different pattern of gastric secretory response.A possible relationship between the parathyroid glands and gastric secretion was suggested nearly 50 years ago in experiments with innervated (Pavlov) gastric pouches. Keeton (1914) found that parathyroidectomy reduced secretion in the cat, and Rogers, Rahe, Fawcett, and Hackett (1915) observed that a crude extract of parathyroid tissue caused an increase in secretion in the dog. Several others have studied the problem from time to time, while today many are interested in it because of the recognition that peptic, and especially duodenal, ulceration is a frequent feature of both primary hyperparathyroidism and the syndrome of multiple endocrine adenopathy in man (Welbourn and Ward, 1962 Parathyroidectomy (partial or total and usually combined with thyroidectomy) has always been found to reduce the secretion of acid and of pepsin in animals, and subsequent injections of calcium salts have restored it (Keeton, 1914;Chang and Sloan, 1927). Here, however, it is difficult to distinguish between the separate influences of the thyroid and the parathyroid glands, even when thyroid substitution therapy is provided, for gastric secretion is reduced by an excess and possibly by a deficiency of thyroxine (Nasset and Goldsmith, 1961). However, in a patient with idiopathic hypoparathyroidism studied very thoroughly by Donegan and Spiro (1960) free acid was completely absent and the concentration of pepsin was very low in the basal juice. An infusion of calcium gluconate and an injection of parathormone both restored secretion rapidly for short periods of time. Prolonged therapy with vitamin D and calcium maintained the secretion of acid and of pepsin at normal levels. Low concentrations of acid in the gastric juice have also been found in infants with hypocalcaemic tetany and restoration of the serum calcium concentration has increased the acidity (Babbott, Johnston, and Haskins, 1923). In both these studies the critical level of serum calcium, at which gastric secretion was restored, was about 7 0 to 7 5 mg. per 100 ml. Parathyroidectomy in patients with primary hyperparathyroidism has not been found to produce any consistent change in secretion (Donegan and Spiro, 1960

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The Effect of Activated Ergosterol and of Parathyroid Hormone on Gastric Secretion in the Dog

Cited by 30 publications

References 2 publications

Effect of Pepsin Inhibitors on Milk Clotting Activity of Crystalline Pepsin.

Effect of Pepsin Inhibitors on Milk Clotting Activity of Crystalline Pepsin.

Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man.

The parathyroids, calcium and gastric secretion in man and the dog

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