The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

Abstract

Acute and chronic sleep loss are linked with a range of negative physiological and psychological outcomes (Kecklund & Axelsson, 2016). While complete sleep deprivation rapidly impedes simple and complex cognitive functions, sleep restriction impairs whole-body homeostasis, leading to undesirable metabolic consequences in the short-and longer-term (Reutrakul & Van Cauter, 2018). Most metabolic tissues including liver (Shigiyama et al., 2018), adipose tissue (Wilms et al., 2019), and skeletal muscle are at risk of developing sleep loss-associated adverse outcomes.Skeletal muscle is a primary regulator of human metabolism. Sleep deprivation (Cedernaes et al., 2015(Cedernaes et al., , 2018 and restriction (Harfmann et al., 2015) have the potential to profoundly affect muscle health by altering gene regulation and substrate metabolism. Even relatively short periods of sleep restriction (less than a week) can compromise

Cortisol and C-Reactive Protein Vary During Sleep Loss and Recovery but Are Not Markers of Neurobehavioral Resilience

“…Although well investigated, the effects of sleep deprivation on cortisol, a hypothalamic–pituitary–adrenal (HPA) axis marker, and C-reactive protein (CRP), an inflammatory marker, remain inconsistent: some studies report no change in cortisol ( Vgontzas et al, 2004 ; Frey et al, 2007 ; van Leeuwen et al, 2009 ; Pejovic et al, 2013 ; Honma et al, 2020 ) or CRP ( Faraut et al, 2011 ; Irwin et al, 2016 ; Choshen-Hillel et al, 2021 ), while others report decreases in cortisol ( Åkerstedt et al, 1980 ) or CRP ( Frey et al, 2007 ; Baek et al, 2020 ), or increases in cortisol ( Leproult et al, 1997 ; Wright et al, 2015 ; Baek et al, 2020 ; Choshen-Hillel et al, 2021 ; Lamon et al, 2021 ) or CRP ( Meier-Ewert et al, 2004 ; van Leeuwen et al, 2009 ). Similarly, studies have found that both acute and prolonged stress increase cortisol ( Jönsson et al, 2010 ; Allen et al, 2014 ) and CRP ( Eraly et al, 2014 ; Kennedy et al, 2014 ), although other studies reported no change in CRP ( La Fratta et al, 2018 ; Szabo et al, 2020 ).…”

Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation

“…Finally, the circadian oscillation of gene expression in both normal and SD conditions support the energetic cost optimization model of circadian gene expression. Although chronic sleep restriction has been proved to show profound impacts on transcription regulation in many peripheral tissues including the liver and adipose tissue (Barclay et al, 2012;Husse et al, 2012), acute sleep deprivation has also been demonstrated to raise risk of developing acute sleep loss-associated adverse outcomes in several peripheral tissues such as adipose tissue (Wilms et al, 2019), and skeletal muscle (Lamon et al, 2021). The RNA-seq data from adipose tissue revealed that acute sleep loss could up-regulate oxidative phosphorylation-and ribosome-related signaling pathways (Cedernaes et al, 2018).…”

“…The RNA-seq data from adipose tissue revealed that acute sleep loss could up-regulate oxidative phosphorylation-and ribosome-related signaling pathways (Cedernaes et al, 2018). Lamon et al (2021) showed that acute sleep deprivation blunted the muscle protein synthesis that affected the muscle protein turnover in skeletal muscle tissue. Taken together, these studies, as well as our current study, indicated that acute sleep deprivation affected gene expression in a tissue-specific manner by targeting different signaling and biological pathways.…”

Gravity in the brain—how it may regulate skeletal muscle metabolism by balancing compressive ischemic changes in the weight‐bearing pituitary and hypothalamus

“…Recently in the Journal, a group of metabolism physiology investigators (Lamon et al, 2021) reported on their controlled study of sleep deprivation in normal healthy adults by looking at skeletal muscle protein synthesis, and specific hormone levels, as well as gene expression. They found that muscle protein synthesis was significantly reduced in sleep deprivation, compared to their control group.…”

“…This endothelial dysfunction would potentially include the microvasculature of white matter in the brain, as well as the microvasculature of muscle. The works of these seemingly divergent groups of investigators might raise the question of whether vascular endothelial dysfunction plays a role in the brain white matter changes seen during sleep deprivation (Jaster, 2021) or in the metabolic changes seen in muscle (Lamon et al, 2021).…”