The effect of antimicrobials agents on the antilysocyme activity of enterobacteria in vitro

Abstract

The fight against infectious animal diseases has resulted in a change in the etiological structure of infectious agents. This is associated with the variability of bacteria and the involvement of opportunistic microorganisms in the infectious process. The emergence and development of the pathological process are largely determined by the reduction in the colonization resistance of the gastrointestinal tract shell and the persistent properties of microorganisms. This paper aims to study the antilysozyme activity of enterobacteria isolated from sick calves with signs of acute intestinal disorders and evaluate the effect of antimicrobial drugs on the antilysozyme activity of enterobacteria in vitro. For this purpose, the suspension of an enterobacteria culture was incubated together with the studied antibiotic, followed by the determination of the anti-lysozyme activity and statistical data processing. Data analysis showed that the anti-lysozyme activity of enterobacteria, when exposed to antimicrobial agents, depended on the agent under study and was determined by the specific characteristics of the microorganism. Most of the studied antibiotics had a predominantly inhibitory effect on the antilysozyme activity of Escherichia coli, and the persistent potential of bacteria of the Proteus genus was enhanced by the same antimicrobial agents.